Not exact matches
ORDO also represents the relationship between the disorders and their
genetic cause (if known), the
mode of inheritance and associated epidemiological data (age
of onset, age
of death, prevalence).
The occurrence
of patellar luxation in certain breeds suggests a
genetic influence, but the
mode of inheritance is unknown; there is a possibility the defect is polygenic.
The German Shepherd Dog and Rough - Coated Collie are particularly at risk and the
mode of inheritance appears to be autosomal recessive (meaning
genetic carriers will appear normal).
Discovery
of genetic links and
of the
mode of inheritance (simple or complex, dominant or recessive) is the work
of researchers, but they must have dogs to study.
Genetic disorders without a known
mode of inheritance should be managed in the same way as polygenic disorders.
They donate
genetic material by swabbing the inside
of a dog's cheek or drawing blood and occasionally do test breedings to help determine
mode of inheritance for some diseases.
Continue to educate themselves about
genetic diseases pertinent to the breed, including, but not limited, to hip and elbow dysplasia, eye diseases, seizure disorders, allergies, heart disorders, and PFK, and information about their
modes of inheritance.
Two important aspects
of the disorder for the breed include a defined
mode of inheritance, and determination
of the pedigree spread
of the
genetic defect in the breed.
The
mode of inheritance has been determined to possibly be, autosomal recessive in Keeshonds16, polygenic with one gene
of major influence in Belgian Tervurens17, and polygenic recessive in Golden Retrievers.18 Once the
mode of inheritance is determined within a breed, we will determine the best technique to try and find a
genetic marker linked to epilepsy gene (s) in each breed.
Genetic variances, trends and
mode of inheritance for hip and elbow dysplasia in Finnish dog populations.
To date, researchers at UC Davis School
of Veterinary Medicine and the Veterinary Genetics Laboratory have determined that «a recessive
mode of inheritance in Haflingers explains some
of the
genetic components involved in the development
of this cancer.
Our pedigree analysis included Swedish vallhund dogs examined in seven different countries, spanning three continents, and was highly suggestive
of a
genetic etiology and an autosomal recessive
mode of inheritance.
Although the definitive
mode of inheritance is often difficult to estimate from pedigrees due to missing phenotypes, our pedigrees in all breeds suggest a strong
genetic influence with multiple affected dogs across generations and even within several litters.
The
mode of inheritance is not known, nor are any
genetic screening tests available.