Sentences with phrase «genetic model organism»

«It is not a good genetic model organism, but it does regenerate — and that makes it an awesome biological model,» says David Gardiner, a developmental biologist at the University of California, Irvine, who has studied axolotl regeneration for decades.

The less - complex nervous system of the fruit fly makes them easier to study than people or even mice, another genetic model organism.

Additionally, genetic model organisms such as Drosophila are highly amenable to directed genetic interaction studies and large - scale genetic screens.

Not exact matches

A year earlier James Watson and Francis Crick had proposed their double - helix model of DNA, the nucleic acid that conveys genetic information from generation to generation in all organisms except certain viruses.

Traditional genetic approaches together with the new wealth of genomic information for both human and model organisms open up strategies by which drugs can be profiled for their ability to selectively kill cells in a molecular context that matches those found in tumors.

She did her master's degree research project at the Institute of Biochemistry and Biophysics (IBB), also in Warsaw, looking at the effect of genetic mutations on the function of an enzyme involved in the biosynthesis of heme, using Saccharomyces cerevisiae as a model organism.

Esvelt plans to develop CRISPR gene drives in nematode worms — a fast - reproducing model organism — that are designed to spread a genetic modification in a local setting and then fizzle out, a concept that other scientists are pursuing.

Drosophila melanogaster, a dipteran (two - winged) insect, is the species of fruit fly that is commonly used in genetic experiments; it is among the most important model organisms.

The Molecular Sciences Institute in Berkeley, California, combines genomic experimentation and computer modeling to predict the behavior of cells and organisms in response to genetic and environmental changes.

The fruit fly Drosophila melanogaster is a heavily studied model organism often used to examine genetic changes during evolution.

But Bowdidge acknowledges that genetic information from the public domain «is still incomplete for the majority of model organisms.»

But geneticists chose Arabidopsis as their model organism based on its relative genetic simplicity, as well as its short generation time.

This finding represents one of the first examples of a genome - wide significant genetic factor to be identified for binge eating in model organisms or humans.

And this is where yeast, worms and flies can help: Although they may not look it, these so - called model organisms share a lot of genetic information with humans.

His group studies the cellular and genetic control of gastrulation movements in zebrafish, one of the model organisms studied at the institute besides Drosophila, the C. elegans worm, frogs, mice, and newts.

Using genetic models in a variety of organisms — yeast, nematodes, fruit flies, zebrafish — PLab aims to identify candidate treatment compounds for each disease, which can then be refined and taken to the clinic with partner companies.

«It's going to be the intense subject of functional studies, studies in model organisms, and genetic follow - up studies in human samples,» Daly says.

Using data from a 2008 outbreak of one of the most - feared «superbugs,» and modern genetic sequencing techniques, a team has successfully modeled, and predicted, the way the organism spread between and within dozens of healthcare facilities.

As our role in the HapMap concluded, we took on a new grant: constructing the genetic map of C. briggsae, a small roundworm similar to the well - known model organism, C. elegans.

That year, I joined the lab of Raymond E. Miller, which played a role in the International HapMap Project and later the genetic map of C. briggsae, a model organism related to C. elegans.

Pol III was inhibited using a variety of genetic techniques across several different model organisms, from flies and worms to yeast.

The zebrafish is a good choice because of its similarity to humans as a vertebrate, its transparency as an embryo, and the powerful genetic tools available in this model organism.

There, she has established the worm C. elegans as a novel model organism to examine the cellular transformations involved during a direct reprogramming event in vivo, as well as the genetic cascade involved.

Zebrafish is a an outstanding model organism to investigate these questions due to its advantages in live imaging and its improving ease of genetic manipulations.

However, since optogenetics is reliant on genetic modification, its use is primarily limited to relatively few model organisms.

«Unlike model organisms with large collections of mutant strains to draw upon, the lack of reverse genetic tools in the mosquito has made it is very difficult to assign functions to genes in a definitive manner,» Adelman said.

Since ants are not afforded the molecular and genetic tools of traditional model organisms, we will begin addressing the question of colony queen number with a functional genomics approach.

Furthermore, new genome - editing technologies such as CRISPR / Cas9 now enable the efficient derivation of precision disease models incorporating patient - specific genetic variants as a means of recapitulating essential aspects of human disease in mouse and other model organisms.

Methanosarcina acetivorans was sequenced in part because genetic tools are available to modify the organism in the laboratory, making it a model species for methanogens.

In 1997, when few genome sequences were available, Hieter helped create XREFdb, a public database that linked the functional annotations of genes studied in model organisms with the phenotypic annotations on the human and mouse genetic maps.

In addition, projects to perform genetic interaction screens on disease genes in model organisms (yeast, worm, fly, fish) will not be considered, unless the project includes substantive specific aims that investigate the disease relevance of any new genes discovered in human or mammalian model systems.

When the Human Genome Project was launched in 1990, it included the mouse as one of its five central model organisms and targeted the creation of genetic, physical and sequence maps of the mouse genome.

An Independent Basic Researcher studies genetic mechanisms in humans or model organisms in order to understand biological processes.

This understanding can be gained from studies of model organisms, in vitro experiments, bioinformatic analyses and human genetic studies.

New approaches to microscopy, precision laser ablation of individual cells and capillaries, and genetic engineering of model organisms are opening new vistas for exploring the brain and how it works.

Transgenic and gene knockout / knockin technologies have become important experimental tools for assigning functions to genes at the level of whole complexity of organism, creating models of genetic disorders, evaluating effects drugs and toxins, thus helping to answer fundamental issues in basic and applied research.

Model Organisms (Julian Dow, Section Editor): This section covers genetic models, from mouse to yeast.

Model organisms are not restricted to mammalian models, and they include genetically modified or mutant organisms and embryos, as well as relevant protocols and genetic and phenotypic data for mutant strains.

The fruit fly is an ideal model organism for such a task, because of its sophisticated genetic tools to analyze neurons and manipulate neural circuits in the brain.

Indeed, key aspects of most human disorders can be modeled in experimentally tractable organisms through the analysis of orthologous genes and pathways, using the genetic, biochemical and cell biological toolboxes that have been developed in each model organism.

In addition to sequencing the 3 billion letters in the human genetic instruction book, researchers involved in the Human Genome Project have already sequenced the genomes of a number of important model organisms that are commonly used as surrogates in studying human biology.

Interspecies comparison and the introduction of specific genetic changes in short - and long - lived model organisms are used to delineate genetic factors influencing the aging process.

Insights from model organisms have long helped scientists understand the biology behind such genetic diseases, but in recent years model organism researchers have become even more directly involved in diagnosing the millions of people affected — and in searching for treatments.