Sentences with phrase «genetic modifiers»
The phrase "genetic modifiers" refers to certain factors or substances that can change or influence how our genes work or affect our traits. They can either enhance or weaken the effects of our genes, making them more or less noticeable in determining our characteristics or health. Full definition
Based on those differences, Kaye and Finkbeiner developed tests that can be used in their search for genetic modifiers.
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Lisa M. Guay - Woodford, M.D. University of Alabama - Birmingham School of Medicine Genetic modifiers in recessive polycystic kidney disease: implications for pathogenesis and therapeutics
The present study was aimed at identifying genetic modifiers modulating AAO in a large cohort of Italian FTD patients.
It is not yet known why some dogs will experience late - onset PRA, however, it is likely due to the presence of other genetic modifiers that have not been determined at this time.
In collaboration with Dr. A. Gitler (Stanford University, USA), genome - wide genetic modifier screens were first performed in yeast.
Future studies on genetic modifiers in FTD are warranted.
Candidate genetic modifiers for breast and ovarian cancer risk in BRCA1 and BRCA2 mutation carriers.
4:30 pm - 5:30 pm Gerard P. Zambetti, PhD St. Jude Children's Research Hospital The hypomorphic Brazilian mutant TP53 - R337H and variable tumor susceptibility: identification of a potential genetic modifier
Tamim H. Shaikh, Ph.D., CU School of Medicine: Research genetic modifiers of autism spectrum disorders in patients with Down syndrome
Rapture discovered a powerful genetic modifier called ADAM, and the city slowly crumbled under the financial, political, and (of course) biological weight of such a discovery.
«We created a pipeline to identify genetic modifiers and test them in patient - derived iPS cells, which may explain biological mechanisms underlying the differences in age of onset of Huntington's disease,» said Kaye.
«Other genetic modifiers must be involved.»
The researchers then collaborated with many groups in the U.S. and Europe — including the European Huntington Disease Network — to form the Genetic Modifiers of HD (GeM - HD) consortium, which ran a third GWA analysis of another 2,131 patients, bringing the total number of participants to 4,082.
They will then compare those sequences to look for differences that might point to genetic modifiers.
«We believe that a genetic modifier must have a functional link to the disease process.
«One reason may be that certain people have a genetic modifier.
We are now using these models to study the gene function and complex mechanisms underlying disease pathways, with a focus on genetic background effects, genetic modifiers and interaction partners.
Knowledge of genetic modifiers and interaction partners is critically important in understanding the pathways that lead from a primary genetic defect to an observable phenotype.
One way they have looked for these potential «genetic modifiers,» has been through a candidate gene approach, methodically hand - picking their most likely candidates from the 20,000 - some genes in the human genome.
Project Title: Towards the discovery of genetic modifiers and targets for future Huntington's disease treatments
There are other genetic factors such as the «chincilla» gene and genetic modifiers that act together with the liver gene to cause the yellow markings.