Not exact matches
But the fact is something in the
genetic make up and hormones of baby boys expose them to a higher
risk of
autism than girls (
for those who can not sleep without knowing so those weird medical terms, girls tend to have lower levels of vasopressin and higher levels of natural oxytocin).
Risks for autism and schizophrenia rise
for kids of older fathers, and a new
genetic study suggests why
The largest of its kind, the study examined
genetic data in 100,000 individuals including 40,000 people with a diagnosis of schizophrenia and also found that some of the genes identified as increasing
risk for schizophrenia have previously been associated with other neurodevelopmental disorders, including intellectual disability and
autism spectrum disorders.
But looking
for individual blips in the
genetic code did not prove a reliable way to identify
risk factors
for early - onset diseases like
autism.
Then she learned that people with 22q duplication — abnormal repetition, or duplication, of
genetic material in chromosome 22 — had learning delays and sometimes
autism, but a lower
risk for schizophrenia than that found in the general population.
«Brain anatomy differs in people with 22q
genetic risk for schizophrenia,
autism: Deletions or duplications of DNA along 22nd chromosome hint at biological underpinnings of these disorders.»
The team found that
genetic variants that contribute to higher scores on the Eyes Test also increase the
risk for anorexia, but not
autism.
Next, Shelton hopes to look
for autism risk from pesticide exposure among mothers with certain
genetic variations.
This rare
genetic disorder predisposes patients to increased
risks for multiple kinds of cancers as well as neurodevelopmental disorders such as
autism.
A more recent interest concerns infants and children at high
risk for developing
autism (such as those with an older sibling with
autism or who have a particular
genetic variance).
Dr. Bailey - Wilson specializes in statistical genetics and
genetic epidemiology and is especially interested in
risk factors
for lung cancer, prostate cancer, eye disorders,
autism and oral clefts.
The story in a nutshell: the Skafidas paper proposes a method
for generating a
genetic risk score
for autism spectrum disorder (ASD) based on a small number of SNPs.
Patients with Alzheimer's disease, Fragile X syndrome, Down syndrome, and
autism are particularly susceptible to seizures, 12 and the focus of much research at the Waisman Center of Developmental Disabilities has been on the myriad ways drugs, diet and
genetic manipulation can affect amyloid beta levels, seizure threshold and behavioral phenotypes.13 In an editorial entitled «Concocting the Right Diet
for Brain Health» published December 2011 in Translational Medicine, Dr. Westmark expressed concern about the
risks of soy: «The prevailing view is soy is healthy, but much remains to be learned regarding its effects on brain development and function.»
Perhaps
for this reason, the etiology of ASD is not well defined and the combinations of environmental and
genetic factors that protect against or increase
risk of developing
autism are not well understood.
We are exploring new insights into the
genetic roots of
autism; finding pediatric bio-behavioral markers of bipolar disorder; creating effective therapies
for OCD; devising effective prevention strategies
for adolescent sexual
risk behaviors and obesity; and much more.