The fish, which share many of the same genes as humans, are ideal for
genetic studies because of their rapid rate of reproduction and because their genes can be readily mutated.
The team focused on mtDNA, which is often employed in
genetic studies because it is easier to sequence and allows analysis of huge population samples.
The Old Order Amish are ideal for
genetic studies because they are a genetically homogenous population tracing their ancestry back 14 generations to a small group that came to Pennsylvania from Europe in the mid-1700s.
Flies are ideal for
genetic studies because they have short life spans and are small, which means that researchers can breed and interbreed thousands of them in the laboratory until interesting mutations crop up.
Not exact matches
«We suspected that the young are most vulnerable
because of their immature immune systems, but we didn't have a lot of hard evidence to show that before,» said
study lead author Bo Hang, a Berkeley Lab staff scientist who previously found that thirdhand smoke could lead to
genetic mutations in human cells.
Study have been made, pregnancy is not the only way or symptom to get stretch marks,
because genetic history do play role with stretch mark appearing.
Because there is a clear
genetic predisposition to IBD, these populations should probably be composed of families that include persons who already have IBD [such as the
studies conducted by Koletzko et al (20, 26)-RSB-.
Because the prion - forming protein identified in the
study normally functions as a regulator of gene activity, the researchers say their discovery raises the possibility that when it switches to a prion state, it could alter
genetic expression and bacterial behavior.
Meanwhile, the gene - rich X is the most intensely
studied of the 23 chromosomes, largely
because of its role in rendering men vulnerable to an estimated 300
genetic diseases and disorders associated with those mutations — from color blindness to muscular dystrophy to more than 200 brain disorders.
While mouse models have traditionally been used in
studying the
genetic disorder, Deng said the animal model is inadequate
because the human brain is more complicated, and much of that complexity arises from astroglia cells, the star - shaped cells that play an important role in the physical structure of the brain as well as in the transmission of nerve impulses.
«Without the comparison, you really can't
study this process,
because you don't know the
genetic capabilities of the progenitor» Dale says.
In addition, it's been difficult to repeat the findings from individual
genetic studies — partly, researchers think,
because autism is so variable and may really be many different diseases.
Because environmental exposures have not had time to impact IBD progression in children, researchers have a clearer
genetic picture of the disease allowing them to pick out additional genes overlooked in adult research, says senior
study author Hakon Hakonarson, director of the Center for Applied Genomics at The Children's Hospital of Philadelphia.
So I clicked on it: «
Because genetic association
studies are generally performed in populations of a particular ethnic background [European, Asian, African], we can not know whether the associations will also apply to those of a mixed background.
It is difficult at this stage to foresee the full impact of post-zygotic mutations in terms of treatment options for disease
because the
study was mainly focused on the technological aspects of these
genetic changes, the researchers say.
TEDDY is
studying celiac disease and type 1 diabetes
because both are autoimmune diseases with some of the same
genetic risk factors.
The same process has been
studied as a potential
genetic therapy for more than a decade,
because you can target any disease gene with matching dsRNA.
«This
study is exciting
because it shows that changes within the body can affect the progression of a disorder caused by a
genetic mutation,» said Jim I. Koenig, Ph.D., program director at NINDS.
Europeans must have incurred a rapid change in their
genetic make - up
because it held an evolutionary advantage for them to be able to digest milk, says Mark Thomas at University College London in the UK, who carried out the
study with colleagues.
They completed another
study that showed a NOTCH1
genetic mutation likely ensured those carrying it eventually would suffer from heart valve disease
because it leads to CDH - 11 overproduction.
«We are particularly interested in
genetic variants that are not common in the population (those carried by less than 1 and 20 women)
because uncommon variants are not well
studied and evidence suggests they may significantly contribute to cancer risk.»
Neanderthal
genetic material is found in only small amounts in the genomes of modern humans
because, after interbreeding, natural selection removed large numbers of weakly deleterious Neanderthal gene variants, according to a
study by Ivan Juric and colleagues at the University of California, Davis, published November 8th, 2016 in PLOS Genetics.
Even as advances in ancient - DNA technology have made it possible to probe population mixing and large - scale migrations that occurred thousands of years ago, researchers have had trouble
studying the
genetic history of the Near East
because the region's warm climate has degraded much of the DNA in unearthed bones.
Because there is a known clinical connection between eye melanoma and skin cancer, in this
study researchers sought to determine whether there were commonly shared
genetic factors between both diseases, as the inherited
genetic risk of skin melanoma has been more extensively explored in previous medical literature.
This is useful
because when environmental factors can be held constant in a
study,
genetic factors may surface more readily.
Twin
studies are valuable
because they help distinguish between
genetic and environmental contributors.
Blue eyes have their hue
because of a single
genetic mutation that occurred fewer than 10,000 years ago in one individual and swept rapidly through the European population, according to a
study published in the journal Human Genetics in January.
Because RNA can do many things at once, those
studying the origins of life have long thought that it was the first
genetic material.
«It was a surprise,
because the
genetic sequences from the meat didn't match any of the known species,» says Scott Baker, a cetacean geneticist now at Oregon State University's Marine Mammal Institute in Newport, and one of the authors of the
study.
E. coli is popular in
genetic engineering
because it is deeply
studied and quite hardy, able to tolerate
genetic changes well, says chemical engineer Jay Keasling of the University of California, Berkeley.
And
because researchers break apart and then reassemble the 3 - billion - letter - long
genetic instruction book in order to analyze it, sections that have duplicated genes are harder to put in the right order and thus harder to
study, which was the case with the region containing the red blood cell protein DNA.
They have generated excitement over the past few decades
because scientists can
study them in the laboratory to discover the
genetic switches that control the development of specialized tissues in the embryo and fetus, and also
because of their potential to replace body tissues that have broken down, such as pancreatic cells in those with diabetes or heart muscle cells in those with congestive heart failure.
Because the mice involved in the
study were genetically similar, researchers ruled out a
genetic link to the different responses.
«These results are exciting,
because it means we could use an easily accessible blood test to help diagnose people who have the premutation
genetic abnormality and identify who is more likely to have problems and begin early treatment,» said
study author Kim M. Cornish, PhD, of Monash University in Victoria, Australia.
The team says that this was one of the most compelling aspects of their
study,
because it speaks to the remarkable plasticity that exists in the
genetic programs regulating inner ear development.
Conservationists are debating, for example, whether the western grey wolf should have been removed from the Endangered Species list
because genetic studies suggest some of them are wolf - coyote hybrids.
The three other populations that the researchers
studied are also losing
genetic variation — and they didn't have much to begin with,
because each was founded by a small number of Kapiti birds, the scientists report online today in the Proceedings of the Royal Society B.
A
genetic variant that increases the risk of testicular cancer may be favored by evolution
because it helps protect those with fair skin from the sun's damaging ultraviolet rays, according to a new
study.
So that explains why genes look so feeble in twin
studies,
because their potency is masked by the fact that they are correlated with
genetic differences.
The team, co-led by Sebastian Suerbaum, chose to
study H. pylori,
because it is not easily transmitted, has 50 times the
genetic diversity of humans, and exchanges genes frequently with other members of its species.
Because they have very simple body shapes, no legs and no eyes, for example, they were particularly useful for this
study of cryptic diversity in pine - feeding species, which can have «huge
genetic diversity with no visible differences,» Normark adds.
These «pluripotent cell lines» will be especially groundbreaking for
studying Gulf War Illness,
because they preserve the
genetic and possibly epigenetic factors specific to disease susceptibility.
The EMBL team hadn't — and the EMBL spokesperson acknowledges that no one thought to do so: «We did not consider this an issue exactly
because of the notoriety of the cells, and the existence of so much molecular biological and
genetic data on these long before our
study.»
Population
genetic studies usually compare thousands of individuals, but the researchers predicted they could detect differences in a much smaller sample
because of the stark contrast between the islanders» blond and dark locks.
«It could be that as your brain is maturing, you become less susceptible to the addictive effects of nicotine
because the
genetic component that is influencing the way nicotine interacts with these receptors may have less effect,» says Chris Amos, a
genetic epidemiologist at the University of Texas M. D. Anderson Cancer Center in Houston, who wasn't involved in the
study.
Rare
genetic diseases like LFS are good
study models
because they tend to proceed from a change in a single gene, as opposed to many, overlapping changes seen in more related common diseases, in this case more common, non-inherited bone cancers.
Alu - insertion polymorphisms are a boon for the
study of human population genetics and primate comparative genomics
because they are neutral
genetic markers of identical descent with known ancestral states.
This
study was selected for the Trainee Paper Spotlight
because it uses multiple techniques to understand disease pathophysiology from identification of
genetic variants to evaluation of their role in disease pathogenesis.
«I recall hearing about a
genetic study where an Italian population did not get heart disease
because they had a natural
genetic variant, and I realized there's lots of
genetic variation out there that can be interesting and useful,» Malhi said.
In adoption
studies,
genetic and rearing environment effects can be separated
because the biological parents are not raising the children; this makes them the optimal choice when evaluating «nature vs. nurture».