Sentences with phrase «genetic types of tumor»

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Drug developer Loxo Oncology said on Tuesday it is partnering with genetic testing company Illumina Inc on a diagnostic tool that will work with Loxo's larotrectinib and another one of its experimental cancer drugs, across tumor types.

April 10 Drug developer Loxo Oncology said on Tuesday it is partnering with genetic testing company Illumina Inc on a diagnostic tool that will work with Loxo's larotrectinib and another one of its experimental cancer drugs, across tumor types.

But one type of childhood brain tumor has stymied efforts to identify a recurring genetic defect.

«Just as normal cells with the same genome differentiate into many different cell types, a single tumor characterized by specific genetic mutations can contain many different types of cells — stem - like and more differentiated cells — with the difference being rooted in their epigenetic information.

Cancer is a heterogeneous disease, with genetic variations occurring between different types of tumors and different patients.

Through their analysis, the researchers determined the genetic alterations found in both the primary tumors and the metastases frequently were a type of genetic abnormality called a copy number alteration, which is when sections of DNA are repeated (i.e. duplicated).

Though vestibular schwannomas affecting both sides are the hallmark of neurofibromatosis type 2 (NF2), a genetic disorder causing tumors to grow at multiple sites throughout a person's life, vestibular schwannomas may also occur sporadically, and on one side only.

In humans, an increased genetic signature of these cells correlated with better outcomes in a variety of tumor types.

Unlike other solid tumors, there has been limited progress in understanding the contribution of genetic risk factors to the development of uveal melanoma, researchers say, primarily due to the absence of comprehensive genetic data from patients as the large sample cohorts for this rare cancer type have not been available for research.

«New tumor analysis method identifies high - risk prostate cancer: Cancer cells» genetic pathways show which patients are likely to develop aggressive types of the disease.»

Answering important clinical questions — such as whether genetic diversity is a risk factor for aggressive tumor development or how it relates to treatment resistance — requires analyzing samples from many patients with different types of cancer.

We believe that each dog breed may correspond to one type of B - or T - cell lymphoma and so studies within and between breeds gives us a unique possibility to understand how the genetic background affects what type of tumor develops, and how its progression is regulated,» says Ingegerd Elvers.

«Our work outlines the genetic similarities of the tissue and cells in different types of tumors and shows the strong relationships mice can have to other human cancers too.»

Overall, including all genomic variations present in most if not all tumor cells (clonal) as well as those present only in subsets of the cancer cells (subclonal) from tumor tissue, the researchers detected a total of 864 genetic changes in tissue samples across the three tumor types, and 627 (73 %) of those were also found in the blood.

That genetic map led to key insights, such as the link between glioblastoma, the deadliest type of brain tumor, and a gene called BEX1.

The types of tumor that can be particularly responsive to immunotherapy generally happen in older people, or people who have genetic factors that allow their tumors to acquire a lot of mutations — so that the tumor has a lot of different antigens that are recognized by the immunotherapy.

«If we can understand the genetic events causing the development of these different types of tumors, we can point away from certain types of treatments and refine the therapies we recommend,» said Mark Applebaum, MD, assistant professor of pediatrics at the University of Chicago Medicine.

This new RNA type is distinct from microRNAs, snippets of genetic material that are also known to influence a person's risk of developing tumors.

While some mutations are common to many types of cancers, other genetic changes may be unique to certain tumors.

However, the long - term genetic stability of this cell type remains to be determined, so as to avoid tumor formation following therapeutic cell transplantations.

Dr. Eng and team create scoring system to facilitate identifying individuals to be referred to PTEN gene testing Researchers have discovered a method for more precise identification of individuals who should undergo testing for genetic mutations of the tumor suppressor gene PTEN, which associates with a variety of conditions including several types of cancers.

Although a large number of genetic alterations that drive the development and progression of many types of cancer have been identified through large - scale research studies, some tumor types have not been deeply characterized.

«The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type,» by Mariia O. Yuneva et al., Cell Metabolism, Feb. 8, 2012.

These efforts have revealed unexpected genetic similarities across different types of tumors.

Tumors are notoriously heterogeneous — the product of genetic mutations that may be common in a particular type of cancer, or exceedingly rare.

Swanton's lab has since followed the work with comprehensive spatial and temporal genetic analyses of other tumor types, including colorectal cancer, showing the ways that faulty DNA replication promotes chromosomal instability in cancer.

BETHESDA, MD — By analyzing the types of gut bacteria present around colorectal tumors, researchers have found a way to predict key genetic mutations in the tumors themselves, a method that could eventually inform the development of colorectal cancer diagnostics and therapeutics.

In addition, because ZVex product candidates have the potential to carry the genetic material of different tumor antigens, as well as immunostimulatory molecules, we can design them to target multiple types of cancers.

Protect against breast cancer: Women who are genetically susceptible to breast cancer may benefit from higher vitamin D levels, as it interferes with the genetic pathway responsible for these types of tumors.

Some tumors carry genetic mutations and the actual tumor sample is submitted to the laboratory to identify the mutation and the type of tumor.