For example, although early clinical trials of Listeria - based vaccines have shown that the neutralized bacterium produces only mild flulike symptoms in human patients with cervical cancer, the various methods of
genetically disarming the bacteria should be explored to find the safest approach for people gravely ill with pancreatic cancer, because these patients are likely to already have
weak immune systems.
Because Imlygic is a
genetically modified herpes simplex 1 virus, it can also cause the kind of herpes infection that can lead to cold sores, so it shouldn't be given to patients with
weak immune systems or pregnant women, the FDA said.