Not exact matches
By invalidating key parts of Myriad's patents, the court has removed a bar that prevented labs using new technology from developing and selling broader one - time tests that search for all known cancer risks, including the BRCA
genes,
geneticists said.
The major concern is that current
gene drives «are probably too powerful for us to seriously consider deploying in conservation,»
says geneticist Neil Gemmell of the University of Otago in Dunedin, New Zealand.
Says David Kurnit, a
geneticist at the University of Michigan Medical Center in Ann Arbor, «I think it will turn out that [the
gene] is very important in understanding Down syndrome.»
«There are so many
genes that can go wrong and give you intellectual disability,»
says André Reis, a medical
geneticist at Erlangen University Hospital in Germany.
Scientists have found a variation of the miR - 182
gene in patients with primary open - angle glaucoma that results in this overexpression,
said Dr. Yutao Liu, vision scientist and human
geneticist in the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University.
Even if technological advances allow researchers to better explain how
genes and environment influence violent behaviour, courts may not take notice,
says Terrie Moffitt, a
geneticist at King's College London and Duke University in Durham, North Carolina, whose previous work influenced the Italian court's decision.
Gene drives aren't much different, says gene drive pioneer Austin Burt, an evolutionary geneticist at Imperial College Lon
Gene drives aren't much different,
says gene drive pioneer Austin Burt, an evolutionary geneticist at Imperial College Lon
gene drive pioneer Austin Burt, an evolutionary
geneticist at Imperial College London.
Matthew Brown, a skeletal
geneticist at the University of Oxford
says the
gene is «a really hot candidate for [human] chondrocalcinosis,» a rare genetic form of joint stiffening that leads to crystal deposition and shows a similarly imbalanced pyrophosphate distribution in the joints.
And the mutation that bestows such remarkable longevity is a
gene that happens to regulate activity in the insulin / IGF signaling pathway,
says Robert Schmookler - Reis of the University of Arkansas, a molecular
geneticist who discovered the relationship between the mutation and the superworm's extraordinary life.
The study clearly shows the utility of the adeno - associated virus in long - lasting
gene transfer,
says molecular
geneticist Rudolph Leibel, an obesity researcher at Columbia University in New York City.
Gene Robinson, a
geneticist at the University of Illinois at Urbana - Champaign,
says that the paper «opens a new line of study on the role of epigenetics in controlling reproductive conflict» in bumblebees.
Medical
geneticists say it could be that jumping
genes rearrange our mental structure.Jumping
genes, or transposons, are bits of DNA that can move freely about the genome.
«There are certain classes of
genes that modern humans inherited from the archaic humans with whom they interbred, which may have helped the modern humans to adapt to the new environments in which they arrived,»
says senior author David Reich, a
geneticist at Harvard Medical School and the Broad Institute.
At the Center for Cell and
Gene Therapy at Baylor College of Medicine in Houston, director Malcolm Brenner, a
geneticist,
says he has turned «AdV from poacher into gamekeeper.»
«It's really cool that they can pinpoint the acquisition of key
genes that allow the movement of this bacteria into fleas,»
says evolutionary
geneticist Hendrik Poinar of McMaster University in Hamilton, Canada, who was not involved with the study.
«The amount of messenger RNA that taste cells choose to make may be the missing link in explaining why some people with «moderate - taster»
genes still are extremely sensitive to bitterness in foods and drinks,»
said Monell taste
geneticist Danielle Reed, PhD, who is an author on the study.
«It's amazing that people don't get the safety issues» of
gene therapy,
says University of Pennsylvania
geneticist H. Lee Sweeney.
«This is the best example that NF1 is a tumor suppressor,»
says David Viskochil, a
geneticist at the University of Utah, although he cautions that the case is not yet closed: There still could be other
genes that play a role in NF tumor development.
The researchers don't yet know how exactly these
genes influence social behavior in either bees or people, but manipulating the
genes in honey bees may shed light on what they do in humans,
says Alan Packer, a
geneticist at the Simons Foundation in New York City, which funds autism research, including this bee work.
«This is a collection of
genes that has largely eluded medical
geneticists,»
says Jacob Mueller, a postdoctoral researcher in Page's lab and first author of the Nature Genetics paper.
The finding means that «it's inescapable that aging is regulated deliberately by
genes,»
says Cynthia Kenyon, a molecular
geneticist at the University of California, San Francisco.
Molecular
geneticist Lisa Baumbach of the University of Miami
says the technique should be useful in screening for inherited forms of breast cancer, for which researchers must use many probes to distinguish among multiple mutations in a
gene.
Because the mouse is so well studied, its sequence will speed the understanding of how our own
genes work,
says mouse
geneticist Barbara Knowles, director of research at the Jackson Laboratory in Bar Harbor, Maine.
Given how useful any insights into
gene function are for understanding the genetic basis of disease, the data are «priceless,»
says Kári Stephánsson, a
geneticist at deCODE in Reykjavík.
Yet, while scientists have identified several
genes that confer specific traits in these species that humans have bred or selected for, such as a special gait in horses, these «are not critical for domestication,»
says Leif Andersson, a
geneticist at Uppsala University in Sweden.
«The message here is that there's no [single] domestication
gene,»
says Peter Andolfatto, an evolutionary
geneticist at Princeton University.
«There are no common variants with large effects,»
says Lavinia Paternoster, a
geneticist at the University of Bristol in the United Kingdom, who plans to work with Kayser in the future on finding more facial
genes.
These findings mark «the first time any novel Alzheimer's
gene has been identified in genomewide studies,»
says Washington University
geneticist Alison Goate, one of Williams's coauthors.
«A number of researchers had been looking for the
genes related to breast cancer and knew where the
genes were likely to be,»
says Arupa Ganguly, a
geneticist at the Hospital of the University of Pennsylvania and one of the plaintiffs in the ACLU suit.
Geneticists say large population databases will be essential to pin down what portion of people carrying potentially harmful mutations will develop disease, and if the effects can be mitigated by other
genes, for example.
Showing that the LCA2
gene therapy treatment works best in children is «a big step» for inherited blindness,
says geneticist Frans Cremers of Radboud University Nijmegen Medical Center in the Netherlands, who wrote an accompanying commentary in The Lancet.
No one
gene can settle the matter,
says geneticist Rosalind Harding of the University of Oxford.
But these crops tend to have low yields and poor grain quality,
says geneticist Pamela Ronald of the University of California, Davis, and breeding these plants without knowing what
genes to extract is time consuming and inefficient.
In this case, as in a recent case of
gene borrowing between weeds (ScienceNOW, 13 November 2008), «humans were indirect agents in promoting these events,»
says Enrico Coen, a
geneticist at the John Innes Centre in Norwich, U.K. Geneticist Sheila Schmutz of the University of Saskatchewan in Canada wonders what else the dogs might have contributed to wolves, say, to metabolism or immune system
geneticist at the John Innes Centre in Norwich, U.K.
Geneticist Sheila Schmutz of the University of Saskatchewan in Canada wonders what else the dogs might have contributed to wolves, say, to metabolism or immune system
Geneticist Sheila Schmutz of the University of Saskatchewan in Canada wonders what else the dogs might have contributed to wolves,
say, to metabolism or immune system function.
«If [the result] holds up in future studies, it suggests that there is a genetic component — and that a single
gene contributes a great deal,»
says Leonid Kruglyak, a
geneticist at the Fred Hutchinson Cancer Research Center in Seattle.
Yet they would be nearly impossible to create without genetic engineering used to evaluate
gene function,
said Nora Lapitan, a wheat
geneticist at Colorado State University.
«The irony of all this,»
says Steven Tanksley, a
geneticist at Cornell University, «is all that diversity of heirlooms can be accounted for by a handful of
genes.
«From the point of this
gene, there is no reason to think that Neandertals did not have language as we do,»
says Planck Institute
geneticist Johannes Krause, a co-author of the study published in Current Biology.
«The old textbook description
says that once maleness is determined by a few Y chromosome
genes and you have gonads, all other sex differences stem from there,»
says geneticist Andrew Clark of Cornell University, who was not involved in either study.
«When we found this causal
gene and were able to reveal it to the family, it was an emotional moment,»
said Natasha Frank, MD, the clinical
geneticist at BWH who treated several members of the family.
Finding a specific
gene responsible for racing performance «takes a lot of work and a lot of time,»
says Steven Tammariello, the lead
geneticist for Lexington - based Performance Genetics.
Although more studies are needed to confirm a genetic link between anxiety and the promoter and its associated serotonin transporter
gene, this DNA «is one of the best prospects for a
gene in anxiety - related behaviors that we have,»
says David Goldman, a
geneticist at the National Institute on Alcohol Abuse and Alcoholism in Rockville, Maryland.
Still, «this is the first clear identification» of a
gene «with direct relevance for language ability,»
says geneticist Svante Pääbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.
Right now, researchers must haplotype by analyzing genetic material from large families, or in their absence track
gene frequencies in lots of individuals, a statistical process that is «prone to error,»
says geneticist Andrew Collins of Southampton University in the United Kingdom.
The
gene's apparently crucial role in embryonic development «is remarkable,»
says William Kimberling, a
geneticist at Creighton Medical School in Omaha, Nebraska, who studies children with BOR.
This ancestor «started off with a whole new set of duplicate
genes,»
says Michael Clegg, a plant
geneticist at the University California, Irvine, who was not involved with the work.
«The exciting thing here is the expansion of a
gene family associated with expression in specific neurons,»
says Evan Eichler, a
geneticist at the University of Washington, Seattle.
Ary Hoffmann, a
geneticist at the University of Melbourne in Australia, welcomes the new candidate
gene, which he
says may help in understanding aggression.
«It's the first example of a circadian clock
gene in a human,»
says Joseph Takahashi, a
geneticist at Northwestern University in Evanston, Illinois.
«Recent increases in chronic diseases like childhood asthma and autism can not be due to major shifts in the human
gene pool,»
says physician and
geneticist Francis Collins, former director of the National Human Genome Research Institute.