Sentences with phrase «genome analysis at»

In collaboration with various experimental groups worldwide, we concentrate on comparative genome analysis at various levels.

Not exact matches

For Chad Nusbaum, co-director of the Genome Sequencing and Analysis program at the Broad Institute of Harvard University and the Massachusetts Institute of Technology (MIT) in Cambridge, the event was a professional milestone.

An analysis of the cat genome led by researchers at Washington University School of Medicine in St. Louis reveals some surprising clues.

The mouse, dog and human genomes are of high quality whereas the three others are at different stages of analysis completion.»

«I think what's interesting about combining whole genome analysis and histopathology is that we can study the tumor at multiple levels,» said co-author Rakopoulos.

The following Berkeley Lab researchers also contributed to the study: Benjamin Bowen, a member of Northen's lab in EGSB and at the Joint Genome Institute, a DOE Office of Science User Facility, helped analyze metabolomics data; Ulas Karaoz in the Earth and Environmental Sciences Area (EESA) analyzed metagenomics data; and Joel Swenson, a former postdoctoral researcher in Biosciences» Biological Systems and Engineering Division, helped conduct correlation and statistical analyses.

Fully sequenced genomes remain rare, so the bulk of the analysis was done by looking at genetic markers known as single nucleotide polymorphisms or SNPs.

Leading on from The Genome Analysis Centre's (TGAC) previous announcement of their new bread wheat genome assembly, the landmark resource is now publically available to download at the European Bioinformatics Institute's (EMBL - EBI) Ensembl database for full anaGenome Analysis Centre's (TGAC) previous announcement of their new bread wheat genome assembly, the landmark resource is now publically available to download at the European Bioinformatics Institute's (EMBL - EBI) Ensembl database for full aAnalysis Centre's (TGAC) previous announcement of their new bread wheat genome assembly, the landmark resource is now publically available to download at the European Bioinformatics Institute's (EMBL - EBI) Ensembl database for full anagenome assembly, the landmark resource is now publically available to download at the European Bioinformatics Institute's (EMBL - EBI) Ensembl database for full analysisanalysis.

In an analysis of ancient genomes published August 4 in Current Biology, researchers at Stockholm University and Uppsala University in Sweden and Middle East Technical University in Turkey report that at least two waves of early European settlers belonged to the same gene pool as farmers in Central Turkey — genealogy that can be traced back to some of the first people to cultivate crops outside of Mesopotamia.

Professor Ed Feil, joint lead author from the Milner Centre for Evolution, at the University of Bath, said: «We've developed user - friendly analysis software that demonstrates how whole genome sequence data can be a powerful tool for pan-European surveillance of MRSA and other important pathogens.

Veeramah is quick to point out Larson's analysis hinged largely on the genome of one ancient pooch, extracted from a 5,000 - year - old fossilized ear bone preserved at a Neolithic site in Ireland called Newgrange.

Before the consortium came together, he had participated in sequencing the genomes of two vocal learners, a songbird and a parrot, but he knew he couldn't do all of the additional sequencing and analysis work that would be required to identify genes related to vocal learning — not by himself, at least — so he teamed up with Genome 10K, a project aiming to collect genomes for 10,000 vertebrate species.

The genome - wide analyses showed that Cpf1 was highly specific, showing fewer off - target cleavage sites (6 for LbCpf1 and 12 for AsCpf1), compared to Cas9, cleaving at > 90 sites in the human genome (Fig. 1a).

An international team of scientists from Singapore, Thailand, China and Australia has cracked the genetic code of the liver fluke parasite, Opisthorchis viverrini, using a unique DNA analysis technique developed at A * STAR's Genome Institute of Singapore (GIS).

«Genome - wide analysis allowed us to identify a gene, VNN - 1, whose expression discriminated between good and poor responders to systemic corticosteroid treatment,» said Gurjit Khurana Hershey, MD, PhD, senior author and director of Asthma Research at Cincinnati Children's.

A comparative analysis with the cacao tree genome also shows that the biosynthesis of caffeine is due to enzymes unique to each species, which appeared at various moments in their evolution.

Researchers who participated in the research are: Bru Cormand, Claudio Toma, Bàrbara Torrico and Alba Tristán, from the Department of Genetics and the Institute of Biomedicine of the University of Barcelona (IBUB), affiliated centres with the campus of international excellence BKC; Concepció Arenas (Department of Statistics of the UB) and Mònica Bayés, researcher from the National Centre for Genome Analysis (CNAG), located at the Barcelona Science Park (PCB - UB), and the groups led by Amaia Hervás, coordinator of the Child and Adolescence Mental Health Unit at the Mutua de Terrassa University Hospital, and Marta Maristany, from Sant Joan de Déu University Hospital, affiliated centres with the campus of international excellence HUBc.

The researchers, including postgraduate students Miaolin Chen at Shanghai Jiao Tong University and Deborah Devis at the University of Adelaide's Waite campus, performed a genome - wide analysis of potential pollen allergens in two model plants, Arabidopsis thaliana (thale cress) and rice by comparing those results among 25 species of plants ranging from simple alga to complex flowering plants.

The three - year study included cell culture studies at Rice as well as a detailed analysis of gene - expression profiles of more than 500 patients from the Cancer Genome Atlas and protein - expression profiles from about 200 MD Anderson patients.

Professor Paul Kellam, Group Leader of Virus Genomics at the Wellcome Trust Sanger Institute, said: «Real - time analysis of virus genomes such as Ebola is an important addition to our toolkit for investigating disease outbreaks.

Eager to get the record straight, Laurent Frantz, now a bioinformaticist at the University of Oxford in the United Kingdom, carried out sophisticated computer analyses of 103 whole genomes sequenced from wild boars and domesticated pig breeds from all over Europe and Asia.

The genome analyses «may be providing incomplete or inaccurate information,» says Kathy Hudson, director of the Genetics and Public Policy Center at Johns Hopkins University.

Added Robert Fulton, director of technology development at Washington University's McDonnell Genome Institute, which contributed to the sequencing and analysis of the data: «This research is a great example of the value of comprehensive genomic analyses and the insights that can be gained from thorough, well - designed studies.

The study has solid geographical sampling, and the team's statistical analysis of two DNA genomes — mitochondrial and nuclear — shows pretty good evidence for the new species, says Bryan Stuart, a curator of herpetology at the North Carolina Museum of Natural Sciences in Raleigh, who was not involved in the work.

At the same meeting, Kerstin Lindblad - Toh of the MIT Broad Institute in Cambridge, Massachusetts, and her colleagues outlined the initial analysis of the 2.4 billion bases of the dog genome.

«The degree of inbreeding determined at high precision with genome analysis agreed rather well with inbreeding estimated from established pedigrees», says Hans Ellegren.

They then used genome - wide analysis to search for genes switched on by KLF4 at a late stage of reprogramming.

Given the number of genomes studied and the sophisticated analysis used, the date for when the species diverges is «the best estimate of what we've gotten so far, and it makes sense,» says Beth Shapiro, an evolutionary biologist at UC Santa Cruz, whose earlier work also suggested these bears split less than a million years ago.

«Using the genome data analysis methods developed by co-author Steve Horvath at UCLA, we have uncovered crucial gene networks and we can now predict possible future genetic disorders at the eight - cell stage.»

The commission took a stab at these complicated questions, issuing new analysis and recommendations for how to manage these increasingly complex issues in medicine, research and with direct - to - consumer tests that allow a patient to send in a cheek swab and get health information (like the personalized genome services kit offered by 23andMe, that was recently blocked by the U.S. Food and Drug Administration).

At first, Sprecher suspected that either they had performed the genetic analysis incorrectly or the missing mutation was hiding in a noncoding or «junk» region of the genome.

The analysis suggests that about 1,000 copy number variations exist in each person, spanning at least 1 percent of the genome.

PhD candidate Ole Kristian Tørresen and senior engineer Lex Nederbragt at the Institute of Biosciences and Centre for Ecological and Evolutionary Synthesis (CEES) have now conducted a more detailed analysis than has been possible ever before, and once again the cod genome has come up with a surprise.

To study evolution across a major vertebrate class, dissect the genomics of complex traits, and resolve a centuries - old debate on the avian species tree, we formed a consortium focused on the sequencing and analyses of at least one genome per avian order.

Given the widespread use of the HeLa cell line, Lars Steinmetz and his colleagues at EMBL decided that conducting an extensive analysis of its genome could illustrate the changes caused by cancer — and also help researchers compare versions of the cell line that have evolved over decades of growth in labs around the world.

Dr. Gitlin is a Science Policy Analyst within the Policy and Program Analysis Branch (PPAB) of the Office of the Director at the National Human Genome Research Institute.

DEEP ROOTS Analysis of the Mnemiopsis leidyi comb jelly's genome suggests it sits at the base of the tree of animal life.

Charlotte Lindqvist of the University at Buffalo, New York, and an international team of researchers have just completed the most comprehensive analysis yet of the polar bear genome.

His analysis was backed up by Nicholson Price, an academic fellow at Harvard Law School in Cambridge, Massachusetts, who found that few, if any, DNA patents would be infringed by companies or clinics sequencing whole genomes of individuals for medical insight.

Bootscanning analysis revealed no evidence for recombination of TMAdV with other adenoviruses at either the whole - genome or individual gene level (Fig.

But in a new study published online in Nature Genetics, a research team led by J.J. Emerson, assistant professor of ecology & evolutionary biology at the Ayala School of Biological Sciences, applies new methods of genome analysis to identify these complex mutations with unprecedented resolution.

In 2012, for example, Willerslev's lab published an analysis of proteins, which are generally longer lived postmortem than genetic material, of 43,000 - year - old woolly mammoth bones.16 And last year, Willerslev, Orlando, and colleagues published a genome - wide nucleosome map and survey of cytosine methylation levels in the DNA they pulled from the 4,000 - year - old hair shafts of a Paleo - Eskimo, effectively launching the field of ancient epigenetics.17 Also last year, Pääbo's group at the Max Planck Institute for Evolutionary Anthropology published the first full DNA methylation maps of the Neanderthal and Denisovan genomes.18 «For the first time we'll be able to address what is the role of epigenomics and epigenetics in evolution,» Willerslev says.

deCODE is delivering on the promise of the new genetics.SM Visit us on the web at www.decode.com; on our diagnostics site at www.decodediagnostics.com; for our pioneering personal genome analysis service, integrating the genetic variants included in these tests and those linked to another twenty common diseases, at www.decodeme.com; and on our blog at www.decodeyou.com.

Previously, I led the human genetics analysis group of the McDonnell Genome Institute at Washington University in St. Louis.

The study was led by Director of Science at The Genome Analysis Centre (TGAC) Federica Di Palma.

The most significant of these was the HiSeq X Ten, a 10 - instrument «factory installation» that enabled the most cost - effective human whole genome sequencing to date: 18,000 genomes per year at a consumables cost of just over $ 1,000 each (note: this does not include the costs of data storage, analysis, or the $ 10 million buy - in).

Based at the Wellcome Trust Sanger Institute, Magnus works on the scientific analysis of high - throughput genome sequencing data for MalariaGEN, primarily on pathogen projects.

The team has representatives from the Wilson Center, Wyss Institute for Biologically Inspired Engineering at Harvard University, Harvard Medical School, Harvard School of Public Health, the Massachusetts Institute of Technology (MIT), Boston University and Arizona State University working in disciplines ranging from genome engineering and public health and ecology to risk and policy analysis.

Cristina Kapustij, M.S., has been named chief of the Policy and Program Analysis Branch (PPAB) at the National Human Genome Research Institute (NHGRI).

Microarray analysis was performed at different time points to determine yeast genome - wide response when exposed to salt, acid, hypoxic conditions, and hydrogen peroxide, as well as ethanol, isopentenol, and other biofuels candidates.