Defeated by an initial project on in vitro fertilization in mice, he had switched to studying how yeast cells duplicate
their genome during cell division.
fertilization in mice, he had switched to studying how yeast cells duplicate
their genome during cell division.
It corrects mutations that arise during the replication of
the genome during cell division.
«And finally, it is much easier to follow a single mitochondrion and mitochondrial
genome during cell division than to follow hundreds or even thousands at the same time,» Torsten Ochsenreiter from the Institute of Cell Biology says.
Not exact matches
During meiosis, the
genome of a diploid germ
cell, which is composed of long segments of DNA packaged into chromosomes, undergoes DNA replication followed by two rounds of
division, resulting in haploid
cells called gametes.
The approach developed by the MGH team focuses on small areas of the human
genome — so - called polyguanine (poly - G) repeats that are particularly susceptible to mutation, with genetic «mistakes» occurring frequently
during cell division.
The team used ChromEMT to image and measure chromatin in resting human
cells and
during cell division (mitosis) when DNA is compacted into its most dense form — the 23 pairs of mitotic chromosomes that are the iconic image of the human
genome.
«We succeeded in describing in detail the machinery required for mitochondrial
genome distribution
during cell division in trypanosomes,» Ochsenreiter says.