Not exact matches
During meiosis, the
genome of a diploid germ cell, which is composed of long segments of DNA packaged into chromosomes, undergoes DNA
replication followed by two rounds of division, resulting in haploid cells called gametes.
Tanaka had sequenced the middle region of the code for NS5B, the enzyme that makes new
genome copies
during replication.
An efficient unfolding of these structures is necessary in order to secure the integrity of the
genome during DNA
replication,» says Nasim Sabouri.
It corrects mutations that arise
during the
replication of the
genome during cell division.
That poses an obvious problem
during S phase: While DNA
replication machineries («replisomes») zip along the chromosomes trying to faithfully duplicate the entire
genome in a matter of just a couple of hours, they encounter — on average — multiple cohesin rings that are already wrapped around DNA.