Sentences with phrase «genome function»

Such genome - wide studies look for factors that influence genome function and disruptions that contribute to complex disease.

«Our study shows that the early stress of separation from a biological parent impacts long - term programming of genome function; this might explain why adopted children may be particularly vulnerable to harsh parenting in terms of their physical and mental health,» said Szyf's co-author, psychologist Elena Grigorenko of the Child Study Center at Yale.

Chromatin is the protein packaging that helps regulate genome function by controlling access to DNA; changes in this packaging can affect gene regulation.

«In studying how RNA - protein interactions govern genome function in the heart, we saw potential for both the generation of knowledge and ultimately the development of new therapy,» Professor Preiss said.

«We have provided biologists with a powerful new tool to experiment with and learn how genomes function,» says Waterston.

Because yeast and other fungi, like humans, are eukaryotes, organisms with a compartmentalized cellular structure and complex mechanisms for control of their gene activity, study of yeast genome function is also a key component of biomedical research.

We apply genetics, genomics, cell biology and biochemical approaches to study how the organization and dynamics of the nuclear organelle affect genome function.

«The importance of DNA sequences in health and disease has been clear for decades, but we only recently have come to realize that the organization of sections of DNA into different physical domains or compartments inside the nucleus is critical to promote distinct genome functions,» said study corresponding author, Gary Karpen, senior scientist at Berkeley Lab's Biological Systems and Engineering Division.

There remains a compelling need to sequence the genomes of many more organisms,» said NHGRI Director Francis S. Collins, M.D., Ph.D. «The ability to compare the genomic sequences of different species has opened a powerful new window into how our own genome functions.

They processed data relating to genetics, including DNA sequences, and to gene expression, as well as epigenetic features — chemical reactions that influence genome functioning and hence phenotype by activating and deactivating genes.

Alterations in DNA methylation, a covalent modification of DNA that regulates genome function, have been associated with early childhood adversity.

«Environmental factors that disturb cellular and physiological processes and have an effect on the individual's predisposition to diseases, such as type 2 diabetes, are likely to do so through active, and reactive, modulation of genome function.

«This is the most radically altered genome to date in terms of genome function.