Using «homologous recombination,» CRISPR can also be used to insert new DNA sequences or even whole genes into
the genome in a precise way.
Not exact matches
«modENCODE will enable us to confirm what we're finding
in the human
genome by manipulating the fly and worm
genomes in a
precise and rapid
way,» said Elise Feingold, PhD, the NHGRI program director
in charge of the ENCODE and modENCODE projects.
«We thought that permanently cutting the
genome would be the more effective
way to silence a gene, but
in fact, CRISPRi is so
precise and binds so tightly to the
genome that it is actually a better
way to silence a gene.»
It turned out that it was safer and more
precise than conventional breeding using mutagenesis for example; GM just moves a couple of genes, whereas conventional breeding mucks about with the entire
genome in a trial and error
way.