You march through
the genome letter by letter and you ask whether that letter affects anything in the brain.»
Not exact matches
But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the
genome - editing technology to cure adult laboratory mice of an inherited liver disease
by correcting a single «
letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»
That means that of all the possible sequences of the four DNA
letters — A, T, C, and G — only a very small subset is represented
by the
genomes of real organisms.
(
By contrast, the report from Reich and Lazaridis samples thousands of single -
letter genetic variants peppered across the
genomes of the 44 individuals).
He founded a new company, Celera, and gambled on a «whole -
genome shotgun assembly» approach, in which the 3 billion «
letters» of human DNA would be fragmented, identified, and then put together in the correct order
by computer.
It takes the 3 billion
letters described
by the Human
Genome Project in 2000, and tries to explain them.
The laws establishing DNA databases attempt to guard privacy
by limiting inspection to only 13 relatively short stretches of DNA among the billions of «
letters» of code that make up the
genome.
DNA sequencing and
genome mapping can thus be compared to dividing a very long text into lots of small pieces that are read separately —
letter by letter, or more exactly: nucleobase per nucleobase.
Last September researchers narrowed that gap between reading our
genome and understanding it
by cataloging the activity of most of its 3 billion
letters.
But now, scientists at the Gladstone Institutes have found a way to efficiently edit the human
genome one
letter at a time — not only boosting researchers» ability to model human disease, but also paving the way for therapies that cure disease —
by fixing these so - called «bugs» in a patient's genetic code.
Although the human and chimpanzee
genomes are distinguished
by 35 million differences in individual DNA «
letters,» only about 50,000 of those differences alter the sequences of proteins.
Reykjavik, ICELAND, December 8, 2008 — deCODE genetics (Nasdaq: DCGN) today announced the discovery
by an international consortium of scientists from deCODE and major European and US academic institutions of a single
letter variation in the human
genome (SNP) that is associated with increased fasting glucose levels and risk of type 2 diabetes (T2D).
The single -
letter variant (or SNP) was discovered
by analyzing the
genomes of a total of more than 16,000 patients and healthy subjects from Iceland, Austria, Germany and the United States.
Reykjavik, ICELAND, December 8, 2008 — deCODE genetics (Nasdaq: DCGN) today announced the discovery
by an international consortium of scientists from deCODE and major European and US academic institutions of a single
letter variation in the human
genome (SNP) that is...
By studying more than 300,000 SNPs (single -
letter variants in the human
genome) across...