The genome of affected dogs is compared to the genome of healthy dogs of the same breed to identify defects implied in the mechanisms of that disease.
This will include robotic DNA extraction, genome - wide mapping with high density gene chips (querying 175,000 DNA markers), and next - gen sequencing of the entire
genome of an affected dog (interrogating every letter of the 2.4 billion letter genetic code).
Investigators at the Broad Institute are attempting to identify the mutation (s) responsible for JRD in Golden Retrievers by comparing
the genomes of affected dogs to the genomes of healthy dogs.
Not exact matches
In fact, Ostrander, who works at the NHGRI's Cancer Genetics and Comparative Genomics Branch, was one
of the lead authors
of a white paper arguing for support to sequence the
dog genome at a level
of quality already available at the time for the mouse, «to better understand the genetic basis
of complex diseases
affecting both human and
dog.»
We propose to use a technique called
genome - wide association analysis to evaluate the differences in the genetic material
of affected dogs (
dogs infected with Aspergillus spp.).
If we can obtain the necessary samples from extremely
affected dogs, we can achieve a successful
genome mapping
of hip dysplasia.