October 1, 2014 PRA Research Update The University of Missouri has used support from the TTHWF to generate separate whole
genome sequences from two different Tibetan Terriers with PRA, one with a relatively early onset and the other with a later onset.
Comparative analysis of
genome sequences from four strains of the Buchnera aphidicola Mp endosymbion of the green peach aphid, Myzus persicae
This annotation was used to query 107 whole
genome sequences from 19 breeds and identified over 5500 alleles across the 550 genes of the seven AR loci: the IG heavy, kappa, and lambda loci; and the TR alpha, beta, gamma, and delta loci.
By comparing
genome sequences from carefully chosen organisms, scientists are able to identify specific DNA sequences that have been conserved throughout the evolution of different species, which is a strong indicator that these sequences reflect functionally important regions of the genome.
Here, we perform a comprehensive investigation using 3,059 newly generated low - depth whole -
genome sequences from eight European isolates and two matched general populations, together with published data from the 1000 Genomes Project and UK10K.
Here, we investigate whether the contemporary HG strategy was already present in the Upper Paleolithic (UP), using complete
genome sequences from Sunghir, a site dated to ~ 34 thousand years BP (kya) containing multiple anatomically modern human (AMH) individuals.
Here, we present whole -
genome sequences from 10 individuals excavated close to Cambridge in the East of England, ranging from the late Iron Age to the middle Anglo - Saxon period.
Complete
genome sequences from more than a thousand organisms as well as data from large - scale protein structure determination projects are also publicly available.
Tracing the Route of Modern Humans out of Africa by Using 225 Human
Genome Sequences from Ethiopians and Egyptians.
He presented a talk about the high - quality
genome sequences from three important food crops in the gourd family at the Cucurbita workshop.
MHRP's molecular epidemiologists played a key role on a research team that analyzed the HIV - 1
genome sequences from infected volunteers in the Step HIV vaccine trial.
Researchers isolated and then analyzed the HIV - 1 whole
genome sequences from 68 newly infected volunteers in the Step study.
By obtaining the entire mitochondrial
genome sequences from cells of ME / CFS patients and an age - matched cohort, it is possible to determine whether cases have accumulated more somatic mutations in mitochondrial DNA than expected.
With the availability of
genome sequences from representative species in whole phyla, rigorous quantitative measurements of genetic distance based on DNA sequence divergence has been used to test existing evolutionary trees and to re-classify organisms in all kingdoms.
The researchers generated 51 new thylacine mitrochondrial DNA
genome sequences from fossil bones and museum specimens — the largest dataset of thylacine DNA to date.
An analysis of whole -
genome sequences from more than 5,000 people has unearthed 18 new candidate genes for autism.
University of Nevada, Reno researchers, led by College of Science Assistant Professor David Alvarez - Ponce, have analyzed 322 animal
genome sequences from the National Center for Biotechnology Information looking for animals that show the presence of active CMAH genes.
In total, we generated 99 EBOV
genome sequences from 78 confirmed EVD patients, representing more than 70 % of the EVD patients diagnosed in Sierra Leone from late May to mid-June; we used multiple extraction methods or time points for 13 patients (table S2).
«Our work demonstrates that the generation of
genome sequences from a large number of archaic human individuals is now technically feasible, and opens the possibility to study Neandertal populations across their temporal and geographical range,» says Janet Kelso, the senior author of the new study.
He at least managed a tie: Both groups have provided increasingly accurate versions of the genome since 2000, and Venter has just published the first
genome sequence from one person (himself) that includes all the chromosomes inherited from his parents.
All that changed this month, with the publication of a 400,000 - year - old mitochondrial
genome sequenced from the remains of an early human found in a cave in Spain.
We obtain
a genome sequence from Kostenki 14 in European Russia dating to 38,700 to 36,200 years ago, one of the oldest fossils of Anatomically Modern Humans from Europe.
Eager to get the record straight, Laurent Frantz, now a bioinformaticist at the University of Oxford in the United Kingdom, carried out sophisticated computer analyses of 103 whole
genomes sequenced from wild boars and domesticated pig breeds from all over Europe and Asia.
Together the pieces represented about 15 % of the camel virus genome and these parts were almost identical to
the genome sequenced from the patient.
Related Sites Science article on the discovery of the Mimivirus Science article on the Mimivirus sequence Science news article on the evolutionary origins of the nucleus Primer on
Genome Sequencing from the Human Genome Project
Not exact matches
Her work has explored why fewer drugs are developed for children, chronicled the
sequencing of her own
genome, and followed the manufacturing of a flu shot
from egg to pharmacy.
The, members of the workshop believe that knowledge gained
from mapping and
sequencing the human
genome can have great benefit for human health and well being.
Dec. 18, 2013 — The most complete
sequence to date of the Neanderthal
genome, using DNA extracted
from a woman's toe bone that dates back 50,000 years, reveals a long history of interbreeding among at least four different types of early humans living in Europe and Asia at that time, according to University of California, Berkeley, scientists.
May 6, 2013 — Take a swab of saliva
from your mouth and within minutes your DNA could be ready for analysis and
genome sequencing with the help of a new device.
A human - chimp comparison revealed some 35 million mutations in the single units of the overall
sequence and also found about 5 million additions to or subtractions
from the
genome involving chunks of DNA
sequence.
With all due respect, if you'd read the actual study, you would see that this was not a whole
genome sequence comparison; rather it was a comparison of mitochondrial 12S rDNA and 16S rDNA
sequences for the purposes of confirming the species relationship between the Pod Mrcaru lizards (P. sicula), the source population
from Pod Kopiste (also P. sicula), and the original indigenous population on Pod Mrcaru (P. mellisellensis).
At least in part to deal with such points, Eigen more recently pointed out that each biological
genome is not a single
sequence of bases on DNA (a unique «point in
sequence space») but rather a fairly large number of variant
sequences that have quite similar — even indistinguishable — biological functions.11 b, 11 c Most of these functionally similar
sequences differ
from the «wild - type»
sequence in only one or a few locations, but some have fairly large discrepancies.
The location of O. coarctata in the rice
genome sequence is at the other end of the spectrum
from that of rice varieties such as IR56.
The 3,000 Rice
Genomes Project (3K RGP) is a collaborative, international research program that has
sequenced 3,024 rice varieties
from 89 countries.
Genome Sequence of Cronobacter sakazakii SP291, a Persistent Thermotolerant Isolate Derived
from a Factory Producing Powdered Infant Formula.
Bioengineer Stephen Quake develops a groundbreaking method to
sequence the
genome of an unborn baby using only a blood sample
from the mother.
To determine how the cells switch
from one type to another, they took three human uterine carcinosarcoma samples and
sequenced the
genomes of cells in two parts of each tumor: the carcinoma and sarcoma components.
As researchers recently
sequenced the
genomes of more than a dozen ancient members of our species, Homo sapiens, in Europe and Asia in rapid succession, they added a third genetic component: a «ghost» lineage of nomads who blew into northeast Europe
from the steppes of western Asia 4000 to 5000 years ago.
More people are getting their
genome sequenced than ever before, so start - ups are offering to help people make money
from their genomic data
Many scientists also argue that destroying the stocks would do little to protect the world
from smallpox, because it is now possible to recreate the virus
from its
genome, which was
sequenced in 1994.
With help
from the Chinese
sequencing giant BGI, B10K has already
sequenced to some degree the
genomes of more than 300 birds, with representatives for each family and subfamily.
Science in the Obama years tilted the needle towards applied research —
from the launch of the ambitious Precision Medicine Initiative to
sequence the
genomes of one million people, to the creation of a string of institutes to foster robotics and other innovative manufacturing technologies in partnership with private industry.
So even though some of the leaders of the 2014 avian tree effort launched B10K, a project aiming to eventually
sequence the whole
genomes of all 10,560 bird species and
from there build «the grand tree,» some bird researchers decided not to wait.
Now that
genomes that can be
sequenced quickly and cheaply, deadly microbes have nowhere to hide
from the gene police.
The research, published on Oct. 13 in
Genome Biology and Evolution, analyzes the genetic material of people living in the region today, identifying DNA
sequences inherited
from Neanderthals.
Researchers were able to extract DNA
from a 430,000 - year - old hominin tooth and leg bone, and then
sequence the individuals»
genomes to determine their lineage.
In February, researchers published the first ancient American human
genome,
sequencing DNA
from the remains of a boy known as Anzick - 1, who was buried about 12,600 years ago in what is now western Montana.
To test their hypothesis, the researchers used next - generation
sequencing (NGS) technology to
sequence the complete set of coding variants
from the
genomes of individuals
from seven populations within and outside Africa, i.e.
from the Democratic Republic of Congo, Namibia, Algeria, Pakistan, Cambodia, Siberia and Mexico.
The estimate of the number of human genes has been repeatedly revised down
from initial predictions of 100,000 or more as
genome sequence quality and gene finding methods have improved, and could continue to drop further.
Taking advantage of the handful of complete human
genome sequences now available, the pair looked at how alleles — the two copies of each gene we inherit
from our parents — differ within a
genome.