The objective of this project is to leverage ongoing human patient exome and whole
genome sequencing efforts to generate precision models...
«What's important about the maize project,» says W. Richard McCombie, Ph.D., CSHL Professor, co-principal investigator on the maize genome project, and a pioneer in
genome sequencing efforts, «is that it provides a reference DNA sequence for the most important agricultural crop in the U.S., making it much easier for people to look at the many variants of different strains or «accessions» of maize.»
We expanded on
our genome sequencing efforts to include efforts in whole genome gene expression analysis and functional analysis of genome variation.
Now, a greater effort to understand its ecological and population history has been made possible by the first, whole - scale
genome sequencing efforts of 57 platypuses across Eastern Australia and Tasmania.
Large - scale
genome sequencing efforts, like the Human Microbiome Project, have focused on the community of microorganisms that live in the human gut.
A consortium of peanut growers, peanut shellers, brokers and food manufacturing groups provided $ 6 million in funding for
the genome sequencing effort through The Peanut Foundation.
The largest population
genome sequencing effort to date is published in Nature.
When it is complete in 2008, EarthScope's web of instruments will provide public data for geoscience, not unlike the way the human
genome sequencing effort has for biology.
Not exact matches
Venter, who is one of the first people to
sequence the human
genome, co-founded the company in
effort to discover early genetic markers for a variety of disorders.
It will focus its initial clinical
sequencing efforts on cancer, teaming up with the Moores Cancer Center at the University of California, San Diego to
sequence the
genomes of every patient who is treated there, as well as perform a full
genome sequence on their tumors.
But rather than buying up a genetic research outfit, it decided to build its own in the form of the Regeneron Genetics Center (RGC), an ambitious four - year old
effort to
sequence as many exomes (the protein - encoding part of the
genome) as possible, pair them with medical records, and accelerate drug development.
So even though some of the leaders of the 2014 avian tree
effort launched B10K, a project aiming to eventually
sequence the whole
genomes of all 10,560 bird species and from there build «the grand tree,» some bird researchers decided not to wait.
Efforts are under way to close the remaining gaps; however, the
sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of
genome structure and preliminary gene annotation and interpretation.
«We have discovered that the two more destructive pathogens share a pattern of parallel changes in their core metabolic pathways that enables them to exploit more efficiently the nutrient resources available in banana,» said Stergiopoulos, who along with bioinformatician Ti - Cheng Chang, led the
effort to
sequence and analyze the fungal
genomes of eumusae leaf spot and yellow sigatoka, comparing their findings with the previously
sequenced black sigatoka
genome sequence.
A recently completed
genome sequence of the new virus has sped up
efforts to come up with a diagnostic test to screen for it
The trust now plans to increase its spending from $ 160 million to $ 325 million over 7 years at the Sanger Centre near Cambridge — Britain's main gene
sequencing laboratory — for more painstaking
efforts to
sequence a third of the human
genome by 2005.
His first book related the story of how he led a private
effort that raced a government - funded consortium to decipher the DNA
sequence that makes up the human
genome.
The 15 AACR scientists, who were already in Washington, D.C., to meet with the U.S. Food and Drug Administration on genetic testing for cancer patients, tossed around ideas including expanding NCI's tumor
genome -
sequencing efforts and getting the government to cover the costs of genomic tumor profiling.
They enable molecular biologists and geneticists to selectively chop DNA into pieces, which can then be assembled into new versions of the gene, inserted into the
genomes of other organisms, or
sequenced as part of an
effort to map an organism's genetic material.
Along the way he led BGI, which moved to Shenzhen in 2007, into some of its most ambitious projects, including an ongoing
effort to
sequence 10,500 bird
genomes.
The
sequencing of the human
genome is gearing up all those
efforts, and with each novel model organism for which the
sequence has been determined, the power of comparative analysis increases.
PHUKET, THAILAND — Three U.S. agencies will award grants totaling $ 12.3 million to help speed an international
effort to
sequence the rice
genome.
As large - scale
genome sequencing projects, such as the Human Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced
genome sequencing projects, such as the Human
Genome Project, near completion, the research community's focus is shifting toward efforts to determine functional information about these sequenced
Genome Project, near completion, the research community's focus is shifting toward
efforts to determine functional information about these
sequenced genes.
As part of the international
effort to
sequence the 17 — billion — base - pair hexaploid bread wheat
genome (2n = 6x = 42 chromosomes), we constructed a bacterial artificial chromosome (BAC)-- based integrated physical map of the largest chromosome, 3B, that alone is 995 megabases.
Rapid advances in
genome sequencing have provided promising new techniques to help researchers conserve endangered species, but
efforts to resurrect extinct animals raise complex legal, ethical and environmental questions, experts said at a 4 November event at AAAS.
The barley
genome sequence also enabled the identification of regions of the
genome that have been vulnerable to genetic bottlenecking during domestication, knowledge that helps to guide breeders to optimize genetic diversity in their crop improvement
efforts.
This was a daunting task, as the barley
genome is almost twice the size of the human
genome and 80 percent of it is composed of highly repetitive
sequences, which can not be assigned accurately to specific positions in the
genome without considerable extra
effort.
National Human
Genome Research Institute Director Francis Collins, one of the leaders behind the public effort to sequence the genome, can now move on to other pro
Genome Research Institute Director Francis Collins, one of the leaders behind the public
effort to
sequence the
genome, can now move on to other pro
genome, can now move on to other projects.
Last year, SciLifeLab researchers also joined an
effort to
sequence the
genomes of microbes living in the Baltic Sea.
Efforts to put individual
genome sequences and accompanying personal health information online in a freely accessible database just got a boost in the United Kingdom.
In today's Nature Genetics, researchers report that they have produced a so - called optical map of the parasite's 14 chromosomes, an achievement that should aid the ongoing
effort to
sequence the Plasmodium
genome.
He led the global
effort to
sequence the
genome of the cacao tree.
Hence, their
effort to
sequence its
genome.
By better understanding the limitations of
genome - wide
sequencing, Vogelstein notes, researchers and policymakers might be better able to direct funding and
efforts to areas, such as Alzheimer's disease, where a person's genetic profile might have a very real effect on their likelihood of getting the disease.
The discovery, the product of a multiyear
effort to provide a high - quality full
genome map of the oil palm plant and to scour the
sequence for genes of importance to both science and industry, has major implications for agriculture and the environment.
In the latest
sequencing effort, Willerslev and researchers from Denmark, China, and the United States analyzed the
genomes of 80 polar bears from Greenland and 10 brown bears from North America and Europe.
Warinner began her graduate studies at Harvard in 2004, just after the
sequencing of the human
genome was completed and by the time she left in 2010,
efforts to survey the human microbiome were in full swing.
As part of a long - standing
effort to study the rampant drug - resistant TB in Samara, a region of Russia about 1,000 kilometers southeast of Moscow, researchers collected TB isolates from 2,348 patients and
sequenced the entire
genomes of 1,000 of them.
The international
sequencing effort led from Max Planck chose a bonobo named Ulindi from the Leipzig Zoo as its subject, partly because she was a female (the chimp
genome was of a male).
Another attendee was Craig Venter, who led a private
effort to
sequence the human
genome in the late 1990s that competed with a public
effort led by Collins.
Through its
effort to develop, produce and distribute a suite of
genome RMs, the consortium is providing medical and research laboratories worldwide with the tools they need to advance clinical applications of whole
genome sequencing, and the FDA with the ability to conduct science - based regulatory oversight of the technology.
If such
efforts succeed, says Robert Waterston, a geneticist who heads the
genome sequencing center at Washington University in St. Louis, Missouri, the technique «could be the start of something impressive.»
PARIS — Scientists have agreed to collaborate on an eagerly awaited
effort to
sequence the
genome of the mosquito Anopheles gambiae, the main vector for the malaria parasite in sub-Saharan Africa.
In an
effort to better understand and help combat the ants, a group of researchers led by Neil Tsutsui at the University of California, Berkeley,
sequenced the
genome of L. humile.
Richard Gibbs and colleagues at the
genome center at Baylor College of Medicine in Houston, Texas, will lead the
effort, and a group at Celera Genomics in Rockville, Maryland, will add brute - force
sequencing power.
«Understanding how Cas9 is able to locate specific 20 - base - pair target
sequences within
genomes that are millions to billions of base pairs long may enable improvements to gene targeting and
genome editing
efforts in bacteria and other types of cells,» says Doudna who holds joint appointments with Berkeley Lab's Physical Biosciences Division and UC Berkeley's Department of Molecular and Cell Biology and Department of Chemistry, and is also an investigator with the Howard Hughes Medical Institute (HHMI).
It has launched projects such as a major
effort to develop knock - out mice (ScienceNOW, 7 September 2006) and The Cancer
Genome Atlas (Science, 16 December 2005, p. 1751), which, with the cancer institute, is
sequencing mutations in human cancers.
In addition to medical
sequencing and technology development
efforts, the
sequencing research network will continue its groundbreaking work in comparative genomics, which involves
sequencing and comparing the
genomes of various organisms.
The award is part of NHGRI's Revolutionary
Genome Sequencing Technologies program, which has award $ 14 million in an effort to enable the everyday use of DNA sequencing technologies by biomedical researchers and health - care
Sequencing Technologies program, which has award $ 14 million in an
effort to enable the everyday use of DNA
sequencing technologies by biomedical researchers and health - care
sequencing technologies by biomedical researchers and health - care providers.
Much of the work to isolate the PHS gene came from Gill and his colleagues»
efforts to fully
sequence the
genome — think genetic blueprint — of common wheat.