The rules for a $ 10 million prize for leaps in
genome sequencing just got a little easier — and a little harder.
«The Neandertal
genome sequence just by itself will not tell us what makes humans special, it will always be in conjunction with other work that really addresses the biology of a specific change,» he says.
Not exact matches
Just last month, the genomic sequencing company Illumina announced it had developed a genome sequencer that can map the human genome for just $ 1,
Just last month, the genomic
sequencing company Illumina announced it had developed a
genome sequencer that can map the human
genome for
just $ 1,
just $ 1,000.
Unlike genotyping, which
just looks for specific parts of DNA and pieces them together, next - generation
sequencing looks at only the protein - encoding parts of your
genome, called the exome.
Their work has made it increasingly clear that for all the popular attention devoted to
genome -
sequencing projects, the epigenome is
just as critical as DNA to the healthy development of organisms, humans included.
He at least managed a tie: Both groups have provided increasingly accurate versions of the
genome since 2000, and Venter has
just published the first
genome sequence from one person (himself) that includes all the chromosomes inherited from his parents.
If all this sounds wildly implausible, bear in mind that the idea of
sequencing an entire human
genome in days seemed nigh on impossible
just a few years ago.
It is the latest in a series of breakthroughs in ancient DNA, coming
just months after the
sequencing of the oldest - ever
genome, from a 700,000 - year - old horse.
If the speed of advancement in this area continues apace, even some of the more formidable challenges, such as single strand
sequencing and the $ 1,000
genome, might be overcome — not
just in our lifetimes, but within the foreseeable future.
«This group of plants are unique because their
genomes are
just absolutely full of repeated
sequences.
Not only has the parasitic micro jellyfish evolved a stripped - down body plan of
just a few cells, but via data generated at the KU Medical Center's
Genome Sequencing Facility researchers also found the myxozoan genome was drastically simpl
Genome Sequencing Facility researchers also found the myxozoan
genome was drastically simpl
genome was drastically simplified.
SB:
Just having the human
genome sequence is useless.
Then,
just two months later, Venter and his collaborators contributed partial
sequences of nearly 30,000 human genes to a 379 - page atlas of the human
genome published by the journal Nature.
«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole -
genome sequencing or
just targeting some genomic regions with a gene baiting approach,» says Besnard.
Just as the Human
Genome Initiative in the 1990s
sequenced human DNA for the subsequent identification and analysis of genes, so too will the Materials
Genome Initiative
sequence materials for identifying new properties for a variety of applications.
As scientists race to decode
genomes — not
just of humans but of bacteria, yeast, chimps, dogs, whales and plants — the number of DNA
sequences available for analysis has grown 40,000-fold in the past 20 years, providing unprecedented insight into billions of years of species evolution.
«It emphasizes
just how much novelty we can find by
sequencing the
genomes of organisms that can't be grown in the lab,» Koonin said.
The soon - to - be-released complete human
genome sequence is
just one set of data.
Efforts to put individual
genome sequences and accompanying personal health information online in a freely accessible database
just got a boost in the United Kingdom.
In this new study, we show that,
just as these folding maps trace the contour of the
genome as it folds inside the nucleus, they can also guide us through the
sequence itself.»
Scientists have known for years that the
genome is riddled with
sequences that control gene activity and is not
just made up of genes.
Pavel Pevzner and Glenn Tesler compared the
just -
sequenced mouse
genome with its human counterpart and analyzed where rearrangements, a common type of genetic mutation, occur.
In the past decade innovation has taken researchers from
sequencing the human
genome, in 2001, to synthetically creating a bacteriophage in 2003, to
just three years ago, turning one type of bacteria into another by
genome transplantation.
«The
genome sequence of an Anolis lizard is
just now being
sequenced,» Losos adds.
Then
just four months ago, a team of researchers reported that they had likewise
sequenced the complete chimpanzee
genome.
After making his way through
just 4 percent of the viral
genome, Tanaka found he couldn't complete the
sequences and set the project aside.
Warinner began her graduate studies at Harvard in 2004,
just after the
sequencing of the human
genome was completed and by the time she left in 2010, efforts to survey the human microbiome were in full swing.
Mice and humans share approximately 70 percent of the same protein - coding gene
sequences, which is
just 1.5 percent of these
genomes.
Unlike previous studies, which tracked lymphoma progression by monitoring the
sequence of
just one cancer - associated protein, CAPP - Seq can identify a much larger range of mutations in the tumor
genome.
And
just as the
genome of the platypus helped researchers figure out what the first mammalian
genomes looked like, the newly published
sequence of Amborella points to an ancestor that was actually fairly sophisticated genetically.
They
sequenced the complete
genomes of multiple regions in each tumour and looked at which mutations were present in all cells and all regions of each tumour, and which were present in
just some.
«You
just have to
sequence the right group in order to find a [mitochondrial]
genome that might be rare in other geographic regions,» says Ripan Malhi, a geneticist at the University of Illinois, Urbana - Champaign, who wasn't involved in the study.
Sequencing RNA, not
just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the open access journal
Genome Biology.
Just a year after the first individual human
genomes were
sequenced, an international team announced today that it will probe the entire
genomes of about 1000 people.
This research shows that the organisation and control of genes can not be understood by
just looking at the linear
sequence of DNA in the
genome.
This consists of isolating and
sequencing the newly synthesized DNA from cells that have
just entered the replication phase, in order to map on the
genome the sites where replication has begun.
The rabbit
genome had
just been
sequenced.
The most significant of these was the HiSeq X Ten, a 10 - instrument «factory installation» that enabled the most cost - effective human whole
genome sequencing to date: 18,000
genomes per year at a consumables cost of
just over $ 1,000 each (note: this does not include the costs of data storage, analysis, or the $ 10 million buy - in).
We provided
just a small contribution to the
sequencing of the Neanderthal
genome, but here is a link to that story:
An international consortium of more than 60 scientists from the United States, China and Europe has
just published the
genome sequence of watermelon (Citrullus lanatus), information that could dramatically accelerate watermelon breeding towards production of a more nutritious, tastier, and more resistant fruit.
More recently, the
sequencing of the
genomes of thousands of life forms is revealing
just how many and what genes and the proteins they encode have been conserved from the Precambrian.
As a result, we're seeing exome and
genome sequencing studies published all over the place, not
just in genetics / genomics journals but also many that focus on specific tissues (e.g. blood) or diseases (e.g. cancer, metabolic diseases, vision disorders, you name it).
And even then it seemed like yet another confounding discovery that told us
genome sequences are not the full story — indeed, they
just begin to tell it.
After all, the Human
Genome Project, a massive effort of the National Institutes of Health and U.S. Department of Energy to map our complete genetic
sequence, took
just 13 years — 1990 to 2003.
Just last week the successful
sequencing and assembly of the full woolly mammoth
genome — 4 billion base pairs — was announced.
This has important implications for clinical cancer
genome sequencing:
just because a druggable mutation is present doesn't mean it's expressed.
She said the findings underscored the importance of
sequencing the whole
genome, not
just the protein - coding regions — or exome — to identify the mutations driving cancer in children.
Interface of Genomics Research and Genomic Medicine Recent advances in DNA
sequencing technologies mean that it is now possible to conduct genomic analyses, including analysis of the entire
genome of an individual human, that
just a few years ago would have been too costly and slow.
Scientists can now
sequence a person's entire
genome in
just one day, for only one thousand dollars.
An assembled
genome sequence is really
just a long string of DNA nucleotides.