Sentences with phrase «genome structure»

Therefore, the role of genome structure on widespread DNA gain and loss and its subsequent impact on lineage - specific species evolution remains unknown.

Further, neither mechanism takes into account the underlying genome structure.

However, how the interplay between genome structure and gene regulation is established and maintained still has to be discovered.

We have modeled the 3D genome structure of the model organism fission yeast using a genomic approach that combines the molecular biology procedure called chromosome conformation capture (3C) and next - generation DNA sequencing.

We notably follow the time course of structural changes in response to cues that affect gene expression either transiently or permanently: changes in genome structure during transient hormonal response of differentiated cells and stable trans - differentiation of B cells to macrophages.

Research has revealed a new understanding of how an open genome structure supports the long - term and unrestricted developmental potential in embryonic stem cells.

Research led by the Babraham Institute with collaborators in the UK, Canada and Japan has revealed a new understanding of how an open genome structure supports the long - term and unrestricted developmental potential in embryonic stem cells.

Noma is interested in the mechanisms that regulate the three - dimensional genome structure, which influences various nuclear processes such as transcription, DNA replication, repair, and chromosome segregation.

But his scientific interactions with Hurst intensified, and he eventually spent the last 2 years of his Ph.D. in Hurst's lab working on the evolutionary consequences of sexual reproduction on genome structure.

He also plans to leverage the latest sequencing technologies to understand how complex rearrangements impact the tumor epigenome and perturb cancer genome structure over time.

The research, which formed part of a vast study carried out over the past four years by the international Avian Phylogenomics Consortium, involved the analysis of the whole genome structure of the chicken, turkey, Pekin duck, zebra finch and budgerigar.

The comparative genomics analysis could «backtrack» the history of their genes, and showed that the two bacteria have diverged 13.9 million years ago from a common ancestor with a similar genome structure, and possibly a similar lifestyle.

Analyses of genome structure further shored up evidence that the cells that were once Müller glia had been genetically reprogrammed and were now showing characteristics of interneurons.

This hierarchical genome structure means that the impact and likelihood of particular mutations is highly context - specific, resulting in regional variation in both the susceptibility and tolerance to mutations.

To characterise how DNA gain and loss interacts with genome structure, we used our synthetic genomes to analyse the genomic distribution of DNA gain and loss events in hg19 and mm10.

This text covers topics ranging from plant genome structure and the key control points in how genes are expressed, to the mechanisms by which proteins are generated and how their activities are controlled and altered by posttranslational modifications.

Adaptive evolution of chloroplast genome structure inferred using a parametric bootstrap approach

These efforts eventually blossomed into a highly productive program in comparative genomics that provided important insights about genome structure, function, and evolution.

Transposons are known to affect the regulation of gene expression and play major roles in shaping genome structure.

This surprising genome structure is generated and reinforced by two essential protein complexes that bridge the loops and contribute to proper gene regulation.

The more than $ 30 million effort to sequence Tasha «opened everybody's eyes to just how similar the basic genome structure was for dogs and humans — much more so than for the human and laboratory mouse,» Breen says.

Our ongoing studies demonstrate that the condensin and cohesin complexes are key molecular machines that organize the functional 3D genome structures.

The evolution of genome size via DNA gain and loss is not only shaped by higher order factors such as cell size and metabolic rate, but is intimately linked to the underlying genome structure.

Instead, they are organized into a three - dimensional genome structure that participates in various nuclear processes such as transcriptional regulation, DNA replication and repair, as well as chromatin domain formation.

«The importance of these variants has become increasingly clear with surveys completed in the past 18 months that show these differences in genome structure may play a role in susceptibility to certain conditions, such as mental retardation and autism,» the National Institutes of Health, one of the participant organizations, said in a statement.

Efforts are under way to close the remaining gaps; however, the sequence is of sufficient accuracy and contiguity to be declared substantially complete and to support an initial analysis of genome structure and preliminary gene annotation and interpretation.

«There are thousands of chloroplasts per cell, and many loops of DNA per chloroplast, and the genome structure is quite stable.»

«Insertion of some transposable elements can affect the expression and function of protein - coding genes, so the cessation of mobile DNA activity may have slowed the rate of evolution of both genome structure and gene function.»

The forces driving the accumulation and removal of non-coding DNA and ultimately the evolution of genome size in complex organisms are intimately linked to genome structure and organisation.

The phylogenetic position of the cephalochordate amphioxus, together with its relatively simple and evolutionarily conserved morphology and genome structure, has led to its use as a model for studies of animal evolution, with a special focus on the origin of deuterostomes, chordates, and vertebrates.

To accurately model this genome structure, we successfully fused microscopy and genomic data (Tanizawa et al..

By combining the fission yeast, mouse, and human systems with the latest genomic, genetic, cell biological, and biochemical approaches, we seek to determine how condensin and cohesin organize the functional 3D genome structures and participate in various biological processes, including transcriptional regulation and chromosomal dynamics, and how they contribute to oncogenic processes.