Sentences with phrase «genome than genes»

«There's a lot more to the genome than genes,» says Mark Gerstein, a bioinformatician at Yale University.

Not exact matches

In our tests, the Gene Knockout Kit gave us greater than 80 percent knock - out rates for seven targets,» shares Shondra Miller, Ph.D., Director, Center for Advanced Genome Engineering at St. Jude Children's Research Hospital, on Synthego's web site.

Also found in the water bear genome were more copies of an anti-oxidant enzyme and a DNA repair gene than in any other animal.

That gives it more gene - sequencing capacity, Wince - Smith said, than all of the genome centers supported by the U.S. National Institutes of Health combined.

Together, our collective guts have just under 3.3 million bacterial genes, more than 150 times as many as reside in our own genomes.

The genome encodes ∼ 13,600 genes, somewhat fewer than the smaller Caenorhabditis elegansgenome, but with comparable functional diversity.

The researchers determined that CRISPR had successfully corrected a gene that causes blindness, but Kellie Schaefer, a PhD student in the lab of Vinit Mahajan, MD, PhD, associate professor of ophthalmology at Stanford University, and co-author of the study, found that the genomes of two independent gene therapy recipients had sustained more than 1,500 single - nucleotide mutations and more than 100 larger deletions and insertions.

The results show — for the first time, Briggs thinks — that the bacterial genomes change with depth: the micro-organisms at 554 metres carry more mutations in genes that code for energy - related processes like cell division and biosynthesis of amino acids than are seen in their shallower counterparts.

The nonredundant protein sets of flies and worms are similar in size and are only twice that of yeast, but different gene families are expanded in each genome, and the multidomain proteins and signaling pathways of the fly and worm are far more complex than those of yeast.

The discovery that much of the mammalian genome is transcribed, in some places without gaps (so - called transcriptional «forests»), shines a bright light on this embarrassing plentitude: an order of magnitude more transcripts than genes (pp. 1559, 1564, and 1529).

Rather than supporting a genome duplication event at the time when yeast evolved to have twice the number of chromosomes, their data indicated that the duplicated genes had begun to diverge long before.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

Now, in a study that looked at the genomes of more than 6000 people from Latin America, researchers have identified 18 genes that appear to influence hair traits, including the first ever to be associated with graying.

Mitochondria carry only a few genes, but they are so plentiful that it's often easier to find their DNA than the single full human genome in a cell's nucleus.

(Syn 2.0 was an intermediate stage in this process, the first microbe with a genome smaller than that of M. genitalium, which with 525 genes has the fewest of any free - living natural organism.)

«Gene variants modifying Huntington's symptom onset may lead to new therapeutic strategies: Genome - wide association analysis identifies sites associated with earlier - or later - than - expected symptom appearance in human patients.»

This week in Science, researchers led by genome sequencing pioneer Craig Venter report engineering a bacterium to have the smallest genome — and the fewest genes — of any freely living organism, smaller than the flower's by a factor of 282,000.

Compared with earlier methods to tweak the genomes of bacteria, plants, laboratory mice and human cells, the Crispr - Cas9 gene - editing method is fast, precise and cheap, an order of magnitude better than the others.

New genome - sequencing research suggests white European people with two copies of variant forms of MC1R, a gene linked to pale skin and red hair, have faces that appear up to two years older than those who are the same age but don't have both copies.

«It's looking at a much longer trajectory and it's also interrogating the entire genome rather than specific subsets of genes.»

With a diameter in the region of a micrometer and a genome incorporating more than 1,100 genes, these giant viruses, which infect amoebas of the Acanthamoeba genus, had already largely encroached on areas previously thought to be the exclusive domain of bacteria.

They found that the Neanderthal genome shows more similarity with non-African modern humans throughout Europe and Asia than with African modern humans, suggesting that the gene flow between us and Neanderthals most likely occurred outside Africa as humans were en route to Europe, Asia, and New Guinea.

It is typically less expensive to get preselected information about the 20,000 or so genes that make up a person's exome — the section of the genome that provides instructions for making proteins — than to perform a more precision - oriented test that targets a single gene.

The former target, say, using gene editing techniques to inactivate HIV receptors and achieve resistance of blood cells to the virus (which Sangamo BioSciences is working on in clincial trials) is different than helping parents who both carry genes for Huntington's Disease to have a child that is free of the disease (a change to the genome that would be passed on to future generations and would likely not be very commonly needed).

More than a hundred sites in the genome showed strong evidence of recent selection, including genes that affect muscle tissue, hair, hearing, immune - system function, skin pigmentation, sense of smell, and the body's response to heat stress.

«We have fewer genes in our genome than people originally expected because there's this other layer of complexity in the proteome, the collection of proteins expressed by the genome.

Cheaper, and more efficient, gene editing technology that allows scientists to manipulate the human genome with greater ease and precision than ever before is forcing researchers to consider these questions quickly.

After arriving in their new homes, transferred genes follow a different evolutionary path than do genes that evolve within the same genome.

For example, they succeeded in inserting a gene into a predefined position in the genome (knock - in) in more than 60 per cent of all manipulated mouse cells.

Biologists have adapted retroviruses to insert beneficial genes into the genome, rather than their own DNA.

Hadfield echoes Besnard's suggestion to amplify and sequence specific genes rather than whole genomes, if that will answer the research question.

In addition, while innovators are trying to lower the cost of whole - genome sequencing to less than $ 1,000, it's possible that gene patents may add to the cost.

The Epigenetics Research group used these cells to perform genome - wide profiling across more than 20,000 individual genes in these patients.

The genome sequence revealed much more variability than was expected in the genes that encode the amylase enzymes.

The three - year study included cell culture studies at Rice as well as a detailed analysis of gene - expression profiles of more than 500 patients from the Cancer Genome Atlas and protein - expression profiles from about 200 MD Anderson patients.

The human genome, considered as a mass, contains more retrovirus sequences than actual genes.

By analyzing genetic samples for over half a million individuals as part of the GIANT research project, which aims to identify genes that regulate human body and size, researchers found more than 100 locations across the genome that play roles in various obesity traits.

al., tested the hypothesis that herbivores — and their plant diets — have evolved to have greater number of Tas2r bitter taste receptor genes in their genomes than omnivores or carnivores.

The corn genome actually has 12,000 more genes than humans do and manages to stuff them onto 10 chromosomes (as opposed to humans» 23).

The researchers were searching for archaic DNA sequences in those human genomes at frequencies much higher than would be expected if those genes weren't doing people any good.

Its record - setting girth also holds the longest known viral genome, with DNA that stretches for 1.26 million base pairs, and contains an estimated 1,120 protein - coding genes, 14 percent more than Mimivirus's genome.

But the velvet spider genome, together with that of the orb weaver and the house spider, has exposed an unexpected variety of silk genes — «a lot more than we thought,» Coddington says.

Surprisingly, parts of our genome are more similar to the gorilla's than they are to the chimp's, and a few of the same genes previously thought key to our unique evolution are key to theirs, too.

The human genome — the sum total of hereditary information in a person — contains a lot more than the protein - coding genes teenagers learn about in school, a massive international project has found.

Researchers spent nearly four years trying to identify the location of the Sr35 gene in the wheat genome, which contains nearly two times more genetic information than the human genome.

Cancer — to take a familiar example — is best understood as a disease of the genome: a breakdown of the usual checks and balances among genes that keep cells from dividing more than they should.

When scientists first started mapping human genomes and comparing them to other organisms, they were shocked to discover humans don't have that many more genes than flies do.

The number human protein coding genes, which account for less than 2 % of the human genome, have recently been found to number over 20,000.

At first they could not determine more than six bases in the replica DNA, which did not provide enough unique addresses to identify individual genes in the human genome.

Those few studies that have systematically compared individual gene sequences have shown that genes and the human genome may be much more variable than previously thought.