Sentences with phrase «genome wide approaches»

The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.

Not exact matches

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

They selected 151 promising traits and performed a genome - wide approach to identify which, if any, genetic changes regulated a trait.

Large scale sequencing approach and genome wide analysis can be applied on different economic crops for better understanding their evolutionary process and specific traits, providing unique opportunities for further applications.»

Using genome - wide approaches, they found that the Rev - Erb proteins repressed gene expression in macrophages primarily by binding to enhancers.

In their work, Dr. Lessnick and his team used bioinformatics analysis of experimental data in an unbiased genome - wide approach.

Using a genome - wide approach in a new dog model for copper toxicosis, a team of researchers led by Hille Fieten have now revealed that mutations in a copper transporter gene, ATP7A, can ameliorate symptoms of the disease.

These issues represent a technical hurdle to similar genome - wide approaches in this parasite, making Toxoplasma an even more important model for malaria.

In the current work, researchers applied a new approach called genome - wide association, which utilizes a set of markers spanning the entire genome, to compare the DNA of heart disease patients with that of healthy people (ScienceNOW, 26 April).

The genome - wide association strategy may not be the best approach for identifying these remaining variations, says Justine Ellis, a geneticist at the University of Melbourne in Australia.

With this new approach we are able to generate a genome - wide catalogue of all the regions that we are confident interact in groups.»

To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome - wide analyses and chemical biology.

To confirm this approach, Chinwalla et al [17] checked to see if their inferred genome - wide rates of DNA loss were consistent with local estimates.

Genome - wide approaches such as next - generation sequencing are powerful to understand the information flow from genotype to phenotype, and the regulatory complexity accompanying life and disease.

A large variety of methods is used including genetic, molecular and cytogenetic techniques, fluorescence in situ hybridisation and DNA «combing», as well as high throughput sequencing approaches such as DNA - seq for mutation landscape analyses, RNA - seq for transcriptome analyses and ChIP - seq mapping of chromatin - associated proteins and their genome - wide modulation in response to DNA damages.

Leveraging deCODE's ability to conduct genome - wide linkage studies using large extended families from across the population, the company's scientists were able to approach anxiety as a broadly defined disorder that encompasses all of these complexities.

Thus, this rational transcript engineering approach may represent a unique therapeutic opportunity for a wide range of diseases caused by mutations in the mitochondrial genome for which current effective therapies are lacking (2)

We also combine fold recognition approaches and 3D functional descriptors of proteins for genome - wide discovery of remote homologues members of different structural protein families (e.g. chemokines).

Another way of looking at genome - wide association study results is the so called pathway - based approach, which links SNPs considered mutually involved in a pathway.

In our new paper, we have characterized imprinting across a diverse set of human tissues, using a systematic genome - wide approach.

To help create these comprehensive «wiring diagrams,» the CCP works to develop systematic genome - wide approaches to interrogate the structure and function of each circuit.

Our work extends over these different aspects, through the use of fine developmental and molecular dissection, combined with genetic tools (CRISPR) and genome - wide sequencing approaches.

Among vertebrates, the fish model displays easy high density breeding (short generation time), favourable biological peculiarities (accessibility and transparency of the eggs, genome sequenced for both species used on the platform), original technological approaches (confocal and two - photon microscopy), as well as a wide accessibility to fully transparent larvae usable up to 5 days after fertilization.

September 26, 2000 Researchers discover major diabetes susceptibility gene For the first time, a genome - wide approach has identified a major susceptibility gene for a common, genetically complex disorder — type 2 diabetes in Mexican Americans.

Focusing initially on five staple crops — wheat, rice, maize, sorghum and chickpea — the project seeks to empower public plant breeders to use genome - wide approaches to model plant performance in real time using tools that can be shared across diverse species and regions of the world.

First publication of genome - wide association study leveraging deCODE's population approach; Finding to be integrated into deCODE's DNA - based diagnostics program A team of deCODE scientists, along with academic colleagues from the United States, Iceland, Spain and the...

To ask whether genes lying within regions of differentiation were significantly more affected by positive selection than the genome - wide average, we used two approaches.

There she developed an approach, native elongation transcript sequencing, NET - seq, that directly visualizes global transcriptional activity through mapping RNA polymerase density genome - wide with single - nucleotide resolution.

We have addressed adaption to the host, to antibiotics and to vaccine pressure, most recently developing new bacterial genome - wide association approaches to identify genetic determinants responsible for this adaptation.

Genome - wide patterns of isolation do not provide direct information regarding the mechanisms or phenotypes that contribute to reproductive barriers, underscoring both the power of this population genetic approach because it is not constrained by choice of a specific phenotype, but also its limitations.

We have used genome - wide data and a population genetic approach to dissect the genetic basis of reproductive isolation in the European rabbit by taking advantage of natural hybridization between subspecies in the Iberian Peninsula.

Here we show that loss of the BLM helicase complex suppresses FANCC phenotypes and we confirm this interaction in cells deficient for FA complementation group I and D2 (FANCI and FANCD2) that function as part of the FA I - D2 complex, indicating that this interaction is not limited to the FA core complex, hence demonstrating that systematic genome - wide screening approaches can be used to reveal genetic viable interactions for DNA repair defects.

We used a genome - wide approach to evaluate the heritability of this variation in sensitivity of the spiny damselfish, Acanthochromis polyacanthus.

Here we present a rapid genome - wide approach capable of identifying multiple genetic drivers of medically relevant phenotypes within malaria parasites via a single experiment at single gene or allele resolution.

The participating research centers of the CvDC are using a variety of genome - wide approaches to build a higher - order cardiac development network model.

In recent years, a number of genome - wide approaches have identified transcripts present in mouse and human ES cells or their differentiated derivatives using a variety of gene expression profiling methods [24], [27]--[32].

This discovery approach greatly enhances the future potential of epistasis analysis for systems biology, and can complement genome - wide association studies as a means of formulating hypotheses for targeted experimental work.

We use cultivation - independent approaches to get a wider and more realistic perspective of the true diversity, and the new data is used in phylogenomics analysis to gain insight into the evolutionary relationships among those new genomes.

Results: We apply a novel analytical approach to measure and compare transcriptional and epigenetic variability genome - wide across CD14 ⁺ CD16 ^- monocytes, CD66b ⁺ CD16 ⁺ neutrophils, and CD4 ⁺ CD45RA ⁺ naïve T cells from the same 125 healthy individuals.

Specifically, the genome - wide systems biology approaches to dissect the epigenetic processes that become abnormal when aggressive prostate cancer and melanoma initiates, rather than the reductionist «gene - by - gene» classical approaches, are urgently necessary.

A systems biology approach integrating genome ‐ wide genetic variation and transcriptome profiling data from participants of the Framingham Heart Study identifies key regulatory genes and gene networks underlying blood pressure control.

While FDR is a well - recognized approach in biology, one could also argue for using a family wise error rate (FWER), which has been the norm in recent large - scale, genome - wide association studies (GWAS).

In the spring 2013, aware of the importance of the genetic diversity in the Club's breeding strategy, Genoscoper Laboratories approached the Breed Club and its active breeders proposing a pilot project of a whole new genome - wide diversity analysis.

While genome - wide association studies (GWAS) are an efficient approach for the identification of recessive alleles, they require several unrelated affected individuals [17]--[19].