Sentences with phrase «genome wide study»

The perspectives are to upgrade the scale of the functional genomic screen to a genome wide study to get an highlight of all of the biological networks relevant to be targeted for DM1.

Not exact matches

Her work has been funded by several NIH agencies and her current study, funded by the Robert Wood Johnson Foundation Nurse Faculty Scholars Program, examines the interaction between genome - wide association and social environmental factors related to blood pressure among African American hypertensive parents and early risks for high blood pressure among their untreated children.

In yet another scientific reason for mothers to strongly consider breast - feeding their newborns, a new study in the journal Genome Biology finds that babies who are fed breast - milk had a wider range of gut bacteria than formula - fed babies.

In the first genome - wide study of an ancient East Asian, researchers led by Qiaomei Fu, a paleogeneticist at the Chinese Academy of Sciences in Beijing, extracted DNA from the thighbone of the Tianyuan Man — so named because he was found in Tianyuan Cave, 56 kilometers southwest of Beijing.

The study used Mendelian Randomization (MR) techniques to examine publicly available data from genome - wide association studies.

In this genome - wide association study, researchers found gene variants mapping to five loci associated with intrinsic epigenetic age acceleration (IEAA) and gene variants in three loci associated with extrinsic epigenetic age acceleration.

Using a novel method, Whitehead Institute researchers have determined how a non-coding mutation identified in genome - wide association studies (GWAS) can contribute to sporadic Parkinson's disease (PD).

«Genome wide association study of epigenetic aging rates in blood reveals a critical role for TERT.»

Our study provides unique genome - wide perspectives on the adaptive evolution of venom systems as well as protein evolution in general.

In genome - wide association studies (GWAS), researchers focus on typical variations in genomes, so - called SNPs (single nucleotide polymorphisms).

Meta - analyses of genome - wide association studies conducted in these ethnically - diverse populations identified a total of 878 genetic variants belonging to 18 loci associated with asthma risk.

The basis for this project was the GWAS Catalog, where the results of all published genome - wide association studies are recorded.

This study adds five new genomes representing Neandertals from a wider geographic range and from a later time period than what was previously obtained.

The researchers combined data from 22 genome - wide association studies including new data from around 35,000 migraine sufferers.

And he says that the genome - wide studies that failed to reproduce his results lacked sufficient power to reveal the association between TOMM40 and Alzheimer's disease.

Using an approach called a genome - wide association study, researchers scanned complete sets of DNA in thousands of participants, looking for small variations that appear more often in people with the disease than in healthy individuals.

This was puzzling because that locus was not consistent with SLE loci identified by other genome - wide association studies.

The Immunochip for fine - mapping is an important tool for conducting genome - wide association studies of the genetic components of disease.

In their investigations or so - called genome - wide association studies, the team of researchers compared the genetic profile of study participants to the forced vital capacity (FVC), a volume parameter of lung function.

The University of Edinburgh scientists examined genomic and health data from over 52,000 male participants of the UK Biobank, performing a genome - wide association study of baldness.

Reviewing thousands of genome wide associate studies (GWAS) to identify genetic variants in single nucleotide polymorphisms (SNPs), investigators at Dartmouth's Norris Cotton Cancer Center found that some alleles (one of a pair of genes located on a specific chromosome) are more frequently risk - associated with disease than protective.

A second, genome - wide association study scanned the genome for common variants behind autism in more than 10,000 affected children, their families, and controls.

Genome - wide association studies are notoriously weak in identifying variants that strongly determine our health.

While several studies in the intervening years have investigated whether particular genes were responsible for modifying HD onset, this is the first to employ genome - wide association (GWA) analysis, which scans an individual's whole genome to identify chromosomal regions containing variants that are associated with the disease traits that are being studied.

Available in Volume 168, Issue 8 of the American Journal of Medical Genetics: Neuropsychiatric Genetics, the paper, titled, «Using the Coriell Personalized Medicine Collaborative Data to Conduct a Genome - Wide Association Study of Sleep Duration,» draws on data collected from Coriell study participants to establish its findStudy of Sleep Duration,» draws on data collected from Coriell study participants to establish its findstudy participants to establish its findings.

«This is the first genome - wide data on prehistoric humans from the hot tropics, and was made possible by improved methods for preparing skeletal remains» says Ron Pinhasi at University College Dublin, a senior author of the study.

The study was the first of its kind to employ genome - wide reverse engineering to identify the gene pathways that contribute to periodontitis.

«Our approach is likely to «revive» genome - wide association studies as a strategy to identify genetic risk factors and to develop novel treatment options for a wide range of diseases, just as people had hoped for when the genetic code was deciphered a decade ago.»

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

In the study, Dr. Verduijn and Dr. Yuri Milaneschi, along with their colleagues, analyzed genome - wide data of 3331 people, 1539 of whom were diagnosed with MDD, from the Netherlands Study of Depression and Anxstudy, Dr. Verduijn and Dr. Yuri Milaneschi, along with their colleagues, analyzed genome - wide data of 3331 people, 1539 of whom were diagnosed with MDD, from the Netherlands Study of Depression and AnxStudy of Depression and Anxiety.

In a world first researchers from the University's Institute of Translational Medicine, led by Professor Sir Munir Pirmohamed, conducted a genome - wide association study (GWAS) to pinpoint the genes responsible for increasing the risk of a person developing adrenal suppression.

Earlier studies looked at many genes from a few animals or a few genes from many animals, but Brown University biologist Casey Dunn and his team cast a wider net, sampling DNA from all across the genomes of 71 different animals.

All of these studies were genome - wide association studies (GWAS) based on millions of genetic variants called Single Nucleotide Polymorphisms (SNPs).

The research, led by Knut Wittkowski, biostatistician in the Center for Clinical and Translational Science at The Rockefeller University Hospital, is a twist on a traditional data - mining technique known as a genome - wide association study.

The researchers performed a «genome - wide» study in children with newly diagnosed CD, before any treatment, to look for possible epigenetic changes that may affect gene behavior.

Xin Liu, Project Manager from BGI, said «This study not only generates valuable genomic resource including additional wild reference genome, genome - wide variations for further studies and breeding applications on cucumber, but also gave us a better picture about how the cucumber genome evolved during domestication.

A new study finds a wide range of epigenetic changes — alterations in DNA across the genome that may be related to key environmental exposures — in children with Crohn's disease (CD), reports Inflammatory Bowel Diseases, official journal of the Crohn's & Colitis Foundation of America (CCFA).

«This is the first genome - wide study to use bioinformatics and clinical information to systematically identify one lncRNA, which we found to be oncogenic,» Zhang says.

And large, genome - wide studies searching for genetic underpinnings for more common diseases, such as lung cancer or autism, have pointed to the nether regions of the genome between the protein - producing genes — areas that were often thought to contain «junk» DNA that was not part of the pantheon of known genes.

This is the first study to look at prenatal nutrition and genome - wide DNA patterns in adults exposed to severe under - nutrition at different periods of gestation.

The software allowed them to compare the results of the more than 1,400 genome - wide association studies (GWAS) that have been published on the topic so far.

The study evaluated how famine exposure — defined as 900 calories daily or less — during the Dutch Hunger Winter of 1944 - 1945 affected genome - wide DNA methylation levels.

Interestingly, a variant of the WNT10A gene associated with lower levels of its protein's expression has been linked to a greater likelihood of male pattern baldness, according to a recent genome - wide association study.

The software, just like the genome - wide studies it mines, does not predict the relationship between one trait or disease and another, however.

«In the current study, using a genome - wide analysis of DNA methylation, we identified a few PPARα target genes that underwent ligand - activated PPARα - dependent DNA demethylation during the perinatal period and whose DNA methylation status persists into adulthood,» explains a corresponding author Koshi Hashimoto.

«Together with a previously published genome - wide association study, our findings suggest that lower levels of WNT10A may contribute to male pattern baldness in some individuals.»

In 2013, a genome - wide association study of AD in more than 5,500 African Americans identified two genetic risk factors for AD.

«Largest ever genome - wide study strengthens genetic link to obesity.»

Using a genome - wide association study (GWAS) that includes 1600 individuals living in Tanzania, Botswana, or Ethiopia, the authors identified regions of the genome that contribute to skin color variation and carried out a series of analyses to pinpoint the responsible genes.

The Wellcome Trust, the U.K.'s largest biomedical charity, began to put its weight behind genome - wide association studies in 2005 and recruited 200 researchers to analyze the DNA of 17,000 people from across the United Kingdom.