The study, with first author Georg Ehret, M.D., a research associate at Johns Hopkins, was a so - called
genomewide association study involving information gathered on 342,415 people of both European and non-European descent.
To identify what the scientists were convinced had to be more sites, researchers from 265 institutions worldwide banded together to perform
the genomewide association study.
So Chakravarti and colleagues conducted a new
genomewide association study of the disease, comparing the genetic markers of more than 650 people with Hirschsprung's disease, their parents and healthy controls.
With a grant from the Morris Animal Foundation, Antczak, his collaborators Samantha Brooks and Ann Staiger from the University of Florida, and the rest of the team applied
a genomewide association study to compare the genetic makeup of horses with and without sarcoid tumors at more than 50,000 sites in the equine genome.
A genetics research team at Johns Hopkins Medicine has solved a dilemma facing researchers who use
genomewide association studies (GWAS) by developing a new approach that strategically «filters» which genes are worth further study.
Earlier efforts to hunt down disease - causing genes — so - called
genomewide association studies — frequently came up empty - handed because medical researchers had to take cost - saving shortcuts.
Although they have not been implicated directly in pancreatic function,
genomewide association studies have linked the presence of a mutation near the genes to an impaired ability to properly manage fasting blood - glucose levels.
Genomewide association studies are adding to known stretches of DNA connected with type 2 diabetes (colored bars).
Not exact matches
He suggests that combining
genomewide and epigenomewide
association studies can overcome problems of assigning cause and effect to specific alterations among either type of
study alone.