Sentences with phrase «genomic alterations»

During the last decade it has become apparent that many disease traits are best explained on the basis of genomic alterations.

The service profiles 12 cancer genomic alterations so far.

While the finding does not directly lead to a test for immunotherapy response yet, Choueiri said, «We intend to look at these specific genomic alterations in larger, randomized controlled trials, and we hope that one day these findings will be the impetus for prospective clinical trials based on these alterations.»

«We found that colorectal cancer cells survived under the condition of glucose depletion, and their resistance to such conditions depended on genomic alterations rather than on KRAS mutation alone.

As part of an ongoing clinical trial at Rutgers Cancer Institute exploring rare and poor prognosis cancers, investigators sought to identify genomic alterations in 69 patients with gynecologic cancers that were not responding to standard care.

DePinho added that further analyses are needed to verify additional synthetic essential genes in cancer cells that harbor specific genomic alterations as well as to identify potential regulatory interactions and cell - essential mechanisms.

This droplet - digital PCR test detects genomic alterations with a sensitivity as low as 0.1 %.

Melanoma is associated with DNA damage and genomic alterations caused by ultraviolet light.

This could be evidence of a larger genomic alteration, such as uniparental disomy (UPD, meaning that you get two copies of one parent's chromosome rather than one copy from each).

Bacteria have, by evolution, the ability to rapidly adopt beneficial genomic alterations.

Embryonal rhabdomyosarcoma included far more genomic alterations than alveolar subtype tumors.

Targeting genomic alterations resulted in a 42 percent response rate compared to a 22.4 percent response if the biomarker was directed at a protein overexpression.

Yet the vast majority of genomic alterations associated with cancer lie outside protein - coding genes, in what traditionally has been derided as «junk DNA.»

The genomic particularities of HeLa cells relate to their origin from an aggressive cancer and subsequent cultivation in laboratories for decades, both of which cause considerable genomic alterations.

Genomic alterations affecting the P13K / AKT / mTOR pathway are commonly seen among various cancer types (Kandoth, 2013).

Study outcomes for 64 of the cases were available and showed an average 4.97 genomic alterations per tumor.

Unlike other cancer - associated kinases, SYK rarely undergoes mutations or other genomic alterations in cancer cells, remaining in its normal or «wild - type» form.

Reinforcing the need to look beyond genomic alterations to understand the complexity of cancer, researchers from Dana - Farber / Boston Children's Cancer and Blood Disorders Center report that a normal enzyme called SYK pairs with FLT3, the most commonly mutated enzyme found in acute myelogenous leukemia (AML), to promote progression of the disease.

«Frequent genomic alteration is identified in a rare subset of breast cancer.»

Genomic changes can be reversed with subsequent gene drives, though the cassette encoding the guide RNAs and possibly cas9 will remain and any ecological changes resulting from the original genomic alteration will not necessarily be reversed.

In the past two years, our center has published two cases in which WGS revealed clinically - relevant genomic alterations that were missed by standard approaches.

The present study showed that the metabolism of colorectal cancer, distinct from that of pancreatic cancer, depended on genomic alterations, which previously have been uncharacterized, and was not restricted to KRAS mutation alone.

Advances in genomic sequencing technologies have improved the ability to detect molecular aberrations with greater sensitivity and to identify genomic alterations that can be matched to targeted therapies.

Apr. 23 - 24, 2009 Dr. Eng delivered one of two Keynote Addresses at the NCI Workshop on Tumor Microenvironment Charis Eng, MD, PhD, the Sondra J. and Stephen R. Hardis Chair of Cancer Genomic Medicine and founding Chairwoman of the Genomic Medicine Institute, delivered the Keynote Address entitled, «Genomic alterations in solid tumor microenvironment and clinical outcome.»

«This computational analysis method effectively uncovers the functional context of genomic alterations, such as gene mutations, amplifications, or deletions, that drive tumor formation,» said senior author Pablo Tamayo, PhD, professor and co-director of the UC San Diego Moores Cancer Center Genomics and Computational Biology Shared Resource.

The new study, a comprehensive analysis of the genomes of 178 primary cervical cancers, found that over 70 percent of the tumors had genomic alterations in either one or both of two important cell signaling pathways.

When analyzing the biology behind the molecular alterations in these tumors, the researchers found that nearly three - quarters of cervical cancers had genomic alterations in either one or both of the PI3K / MAPK and TGF - beta signaling pathways, which may also provide targets for therapy.

Genomic alterations were reviewed by the Institute's molecular tumor board and recommendations for patient treatment options were made regarding genomically targeted therapies either already approved or used investigationally — including clinical trials.

The cancer cells of some 20 percent of adult and 15 percent of childhood AML patients harbor a genomic alteration called FLT3 - ITD, in which segments of the FLT3 enzyme are duplicated again and again, making the enzyme overactive.

The research and collaboration activities are organized around the central concepts that cancer results from the accumulation of genomic alterations, and that well - defined descriptions of DNA repair mechanisms, cancer genomes, and gene expression landscapes can reveal the vulnerability of cancer to interventions.

DENVER — The use of hybrid capture - based (HC - based) next - generation sequencing (NGS) to identify targetable oncogenic drivers in patients with lung adenocarcinoma results in the detection of genomic alterations (GAs) not identified in routine screening, and impacts treatment decisions and clinical outcomes.

Benefits of having your cancer tested (knowing your genomic alterations) with the CPD, may include:

We find that the emergence of somatic genomic alterations conferring treatment resistance can be more comprehensively detected with noninvasive cfDNA approaches capable of capturing genomic alterations from multiple lesions simultaneously.

The SMF's microarray service offers a comprehensive set of integrated gene expression services that facilitate studying the role of genomic alterations and transcriptional regulation of genes.