Sentences with phrase «genomic analysis approaches»

Not exact matches

Branscomb also sees lots of opportunities in «techniques that are transforming scientific methodology, such as array technology, comparative genomic approaches, proteomics, sequence analysis.»

A genomic approach based on analysis of the host response to infection has been investigated as an alternative.

Interestingly, genomic analyses suggested that ESCC and head and neck squamous cell carcinoma (HNSCC) shared some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking.These findings would provide a brand - new insight into the understandings of ESCC tumorigenesis, and would help clinicians to develop more effective diagnostic and therapeutic approaches for ESCC.

These questions will be addressed by combining unbiased «omics» - approaches (i.e. genomics, transcriptomics, and proteomics) and a targeted genetic analysis with both superresolution live - cell imaging and electron microscopy of nanotube - forming cells.

Our main goal in this project is to use NGS in identification of genetic causes of rare / ultrarare early - onset neurologic diseases, integrating «omics» platforms with systematic approaches to enrich and redefine phenotypic ontology in these conditions, allowing a comprehensive analysis of genomic data.

After this course you should be able to: - Prepare libraries from genomic DNA for amplicon or whole genome approaches to nanopore sequencing - Run ONT devices and assess sequencing performance during a run - Understand the basics of ONT data handling and analysis - Analyse and interpret ONT amplicon data and whole genomic data from bacterial samples

Our research activities are tightly integrated with an advanced genomics facility platform providing cutting - edge technologies for high - throughput analysis and next generation genomic approaches and are supported by the CRS4 leading High Performance Computing centre.

The current explosion of genomic sequence makes this an exciting time to study insect immunity, and although further work will be necessary to extend the analyses we present here, the combination of genome and transcriptome sequencing provides a scalable approach to characterize the inducible immune response across a broad taxonomic range.

The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.

Cellecta Inc., a functional genomics solutions provider, focuses primarily on developing and implementing flexible and scalable broad - based screening and analysis approaches for drug target and biomarker discovery.

We are investigating these and other allied questions using evolutionary genomic approaches, by performing comparative analyses of plant genomes, transcriptomes and proteomes.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaAnalysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence vaanalysis of sequence variation.

RNA sequencing (RNA - seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses.

MELGEN will explore emergent new techniques, for example the Sanger Institute (GRL) and ServiceXS will explore new approaches to genomic data generation from such samples and from fresh tumour and, critically, with other participant groups develop new statistical / bioinformatic approaches to data analysis.

The branch serves as a focal point at the NIH campus for the analysis of a wide variety of large - scale genomic data generated in the course of laboratory and clinical studies, with branch members actively involved in efforts aimed at developing new bioinformatic approaches for the analysis and visualization of these data.

And through approaches that allow the characterization of the entire proteome, researchers are integrating genomic analysis with the analysis of the proteins in tumor cells to learn, in detail, how cancer - associated mutant proteins affect other proteins.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.