The database reveals both global features
of genomic islands and unique features in select groups of bacteria.
Identifying
how genomic islands move and their effect on bacterial physiology could lead to new approaches to bypass bacterial defenses, Hudson said.
Since publishing the genomic analysis in June 2014, Sandia's project has developed an experimental technique that
detects genomic islands on the move.
He says that, while factors causing DT104's hyperpathogenicity have not been completely identified, the strain seems to owe its resistance to multiple antibiotics to an integron — or gene cluster — structure designated as «
Salmonella genomic island 1» (SGI1).
Although there is some evidence for the variable distribution of
genomic islands in B. pseudomallei isolates, little is known about the extent of variation between related strains or their association with disease or environmental survival.
The team built a database
of genomic islands they found in a survey of all sequenced bacteria.
Genomic islands and plasmids carry genes that contribute to everything from metabolism to pathogenicity, and move whole clusters of genes all at once between species.
So far, the database contains nearly 4,000
genomic islands — only a partial list of what bacteria share, Hudson said.
Sandia National Laboratories researchers Kelly Williams, left, and Corey Hudson view a segment of the Klebsiella pneumoniae genome around two
genomic islands.
To better understand how the process works, they focused on the large mobile DNAs, such as plasmids, which exist as free DNA circles apart from the bacterial chromosome, and
genomic islands, which can splice themselves into the chromosome.
Biologists debate whether «
genomic islands» are real and mark a first step in the formation of new species.