Sentences with phrase «genomic profile»

In this webinar, our expert panel will demonstrate how both diagnosis and treatment can be improved and lives saved using next - generation genomic profiling and functional analyses.

Hirshfield KM, Tolkunov D, Zhong H, Ali SM, Stein MN, Murphy S, Vig H, Vazquez A, Glod J, Moss RA, Belyi V, Chan CS, Chen S, Goodell L, Foran D, Yelensky R, Palma NA, Sun JX, Miller VA, Stephens PJ, Ross JS, Kaufman H, Poplin E, Mehnert J, Tan AR, Bertino JR, Aisner J, DiPaola RS, Rodriguez - Rodriguez L, Ganesan S. Clinical Actionability of Comprehensive Genomic Profiling for Management of Rare or Refractory Cancers.

Research from Rutgers Cancer Institute of New Jersey shows genomic profiling identifies genomic mutations in a gene associated with a rare subset of breast cancer — mutations that can not otherwise be identified with standard clinical analysis of cells and tissue.

Research from Rutgers Cancer Institute of New Jersey examining difficult to treat cancer tumors through genomic profiling shows that tumors with alterations in a signaling pathway responsible for cell regulation may respond to targeted therapy regardless of where the tumor originated in the body.

Working with the New York Genome Center, IBM hopes Watson will show which therapies work best on tumours with different genomic profiles.

New Brunswick, N.J. — Research from Rutgers Cancer Institute of New Jersey shows genomic profiling identifies genomic mutations in a gene associated with a rare subset of breast cancer — mutations that can not otherwise be identified with standard clinical analysis of cells and tissue.

Lead author Christina von Roemeling, a graduate student at Mayo Clinic in Florida, used genomic profiling of nearly 100 kidney cancer patient samples to identify genes that were either over-expressed or under - expressed as compared to patient matched normal kidney tissue samples.

Personal genomic profiling has already raised challenges, with regard to how people respond to a clearer understanding of their risk of genetic disease as well as how others — such as employers or insurance companies — might want to access and use the information.

Researchers developed models to examine the influence of driver mutations — mutations that promote cancer development — on the initiation and development of gliomas, and how tumor genomic profiles evolve as the cancer progresses.

«Poor responding gynecologic cancers get boost from genomic profiling.»

Jing Tang, a researcher working in FIMM, wants to integrate drug screening and genomic profiling data in order to find personalized treatment options for leukemia.

The TGen team performed deep genomic profiling, integrating gene copy number, gene expression and DNA methylation datasets on a collection of 35 breast - brain metastases samples.

«Genomic profiling helps provide targeted therapy options for hard to treat cancers.»

«A widespread genomic profiling initiative is expensive, and this cost has been borne by our institutions,» said Laura MacConaill, PhD, of Dana - Farber Cancer Institute and Brigham and Women's Hospital (BWH), the scientific director of the Profile program and corresponding author of the publication.

Recognizing a need to further explore genomic profiling in pediatric malignancies, the Hugs for Brady Foundation has committed $ 300,000 to the precision medicine initiative at Rutgers Cancer Institute of New Jersey.

Dhami J, Hirshfield KM, Ganesan S, Hellmann M, Rojas V, Amorosa JK, Riedlinger GM, Zhong H, Ali SM, Pavlick D, Elvin JA, Rodriguez - Rodriguez L. Comprehensive genomic profiling aids in treatment of a metastatic endometrial cancer.

The unique approach of SEngine combines the results of its functional drug testing with thorough DNA sequencing and advanced bioinformatics in order to prioritize therapies that match patients» individual genomic profiles.

Examples include the study of allelic variation in the human genome and the development of computational methods for the discovery of cancer - associated genes and diagnostic cancer markers using genomic profiles derived from different tumor types.

The study — Genomic profiles of low - grade murine gliomas evolve during progression to glioblastoma — published April 7, shows how these tumors continue to rapidly evolve, becoming ever more genetically diverse, as they become malignant and progress.

«Through genomic profiling, we're identifying alterations that may not have otherwise been visible through standard laboratory testing.

Rodriguez - Rodriguez L, Hirshfield KM, Rojas V, DiPaola RS, Gibbon D, Hellmann M, Isani S, Leiser A, Riedlinger GM, Wagreich A, Ali SM, Elvin JA, Miller VA, Ganesan S. Use of comprehensive genomic profiling to direct point - of - care management of patients with gynecologic cancers.

To look for genetic contraindications or further issues to discuss, I run two different genomic profiles:

Another new source of personal health data is personal genomic profiling, such as that provided by 23andme.

JAX - Clinical Knowledgebase (CKB) is a powerful tool for interpreting complex genomic profiles, and represents a valuable resource for clinicians and translational and clinical researchers around the world.

Research from Rutgers Cancer Institute of New Jersey examining gynecologic cancers that poorly respond to therapy shows genomic profiling can help identify alternate and targeted treatments.

When The Cancer Genome Atlas Research Network reported its genomic profiling of clear - cell kidney tumours, about one - quarter of participants (126 patients) had been operated on at Memorial Sloan Kettering3.

Our study is the first to understand whether some individuals are at higher or lower risk based on their genomic profile.

Through this research, Rutgers Cancer Institute investigators wanted to determine how comprehensive genomic profiling could be used in clinical care to identify alterations affecting this pathway.

With that, it is imperative to identify alternate therapies for this population,» notes Rutgers Cancer Institute Precision Medicine Director Lorna Rodriguez, MD, PhD, who is a professor of obstetrics, gynecology and reproductive sciences at Rutgers Robert Wood Johnson Medical School and lead investigator of work that examined the delivery of point - of - care management to patients with gynecologic malignancies through comprehensive genomic profiling.

This new commitment to the precision medicine initiative will provide additional opportunities over the next three years for physicians to analyze the genomic profiles of pediatric patients to better understand their cancers and help improve treatment options.

The fact that she has found them to be differentially regulated in angiosarcoma tumors has led to the hypothesis that there are epigenetic regulators of these genes that have yet to be identified through the genomic profiling applied to these studies thus far.

By discovering the connections between mutations in cancer and responses to therapy, we hope to be able to better design clinical trials and to be able to predict patients» responses to different therapies based on the genomic profiles of their tumors.

Ecological and genomic profiling of anaerobic methane - oxidizing archaea in a deep granitic environment — Kohei Ino, ISME

Program members have expertise in cellular signaling and molecular biology, breast pathology, genomic profiling, biomedical informatics, medical, surgical, and radiation oncology, clinical trial design, epidemiology, and supportive care studies.

This supports the idea that genomic profiling should be a routine part of pediatric cancer care.

Information gained from this work will serve to enhance the clinical usefulness of findings from genomic sequencing (for example, next - generation sequencing or comprehensive genomic profiling), determine therapeutic approaches based on genomic findings, aid in the development of clinical trials and related options, and provide supportive rationale for exploring new therapies.

Through analysis of the genomic profiles of human lung tumours, we aim to identify novel genes and pathways that are altered during lung cancer development.

To look for genetic contraindications or further issues to discuss, I run two different genomic profiles: 23andme and the Genova Estrogenomic Profile to make sure they are a good candidate.

«That is, the selection of a cancer therapy for an individual dog is based on the genomic profile of its tumor.»

Diets for dogs should be designed and tailored to the genome or genomic profile of the individual in order to optimize physiological balance, disease prevention and treatment, and performance.

«Our partnership with GTG is so significant because, by bringing together the millions of individuals» genomic profiles that Shivom enables with GTG's market - leading tests, as well as those of many other partners, we will create critical mass that accelerates transformative disease prevention and personalized healthcare,» said Dr. Axel Schumacher, co-founder & CEO of Shivom, in a statement.