Sentences with phrase «genomic sequencing approach»

In a study of 124 patients with advanced breast, lung, and prostate cancers, a new, high - intensity genomic sequencing approach detected circulating tumor DNA at a high rate.

Not exact matches

The goal is to identify the genes necessary to install C4 photosynthesis in rice through different approaches, including genomic and transcriptional sequence comparisons and mutant screening.

In theory, insights into the genetic underpinnings of cancer, made possible through genomic sequencing, will allow people with even the hardest - to - treat diagnoses to benefit from individualized treatment approaches.

The move comes in response to the announcement earlier this week of a new U.S. company, launched by sequencing - machine manufacturer Perkin - Elmer and J. Craig Venter of The Institute for Genomic Research, that plans a brute - force approach to sequencing the human genome within 3 years (ScienceNOW, 12 May).

«Depending on the research questions, it may also be important to define the appropriate strategy to use, either whole - genome sequencing or just targeting some genomic regions with a gene baiting approach,» says Besnard.

Branscomb also sees lots of opportunities in «techniques that are transforming scientific methodology, such as array technology, comparative genomic approaches, proteomics, sequence analysis.»

To overcome the extreme genomic complexity, the team used new long - read sequencing technology that boosted the quality of the genome sequence obtained by more than one hundred fold over standard short - read approaches.

And other options do exist: funding from other organizations for evolution - related research has increased, especially for the genomics approaches (large - scale DNA sequencing and bioinformatics) that underpin molecular evolution research.

Without this approach, the results of genomic sequencing would have been swamped with DNA from normal cells, making it difficult to detect cancer - linked DNA errors, Papp says.

Also today, NHGRI and the National Cancer Institute (NCI), both part of the National Institutes of Health (NIH), announced that all three sequencing centers will devote a significant part of their efforts to The Cancer Genome Atlas (TCGA) Pilot Project, which is testing the feasibility of a large - scale, systematic approach to identify important genomic changes involved in cancer.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

After this course you should be able to: - Prepare libraries from genomic DNA for amplicon or whole genome approaches to nanopore sequencing - Run ONT devices and assess sequencing performance during a run - Understand the basics of ONT data handling and analysis - Analyse and interpret ONT amplicon data and whole genomic data from bacterial samples

The current explosion of genomic sequence makes this an exciting time to study insect immunity, and although further work will be necessary to extend the analyses we present here, the combination of genome and transcriptome sequencing provides a scalable approach to characterize the inducible immune response across a broad taxonomic range.

Supervises wet lab, building amplicon, genomic and metagenomic libraries using various approaches to sequence on variety of platforms (illumina as well as PacBio) to study the understanding of the relationship between the microbiome and metabolic diseases.

Information gained from this work will serve to enhance the clinical usefulness of findings from genomic sequencing (for example, next - generation sequencing or comprehensive genomic profiling), determine therapeutic approaches based on genomic findings, aid in the development of clinical trials and related options, and provide supportive rationale for exploring new therapies.

AGBT provides a forum for exchanging information about the latest advances in DNA sequencing technologies, experimental and analytical approaches for genomic studies, and their myriad applications.

Economic Modeling: Our economic modeling core, led by Dr. Ann Wu, uses a variety of modeling approaches to project the medical and financial consequences of genomic medicine, including the use of pharmacogenomic testing to inform medication choices and the use of sequencing as an adjunct to standard newborn screening.

This section invites manuscripts describing (a) Linkage, association, substitution or positional mapping and epigenetic studies in any species; (b) Validation studies of candidate genes using genetically - engineered mutant model organisms; (c) Studies focused on epistatis and gene - environment interactions; (d) Analysis of the functional implications of genomic sequence variation and aim to attach physiological or pharmacogenomic relevance to alterations in genes or proteins; (e) Studies of DNA copy number variants, non-coding RNA, genome deletions, insertions, duplications and other single nucleotide polymorphisms and their relevance to physiology or pharmacology in humans or model organisms, in vitro or in vivo; and (f) Theoretical approaches to analysis of sequence variation.

As a recognized cornerstone for the genomics research community, AGBT provides an outstanding forum for exchanging information about the latest advances in DNA sequencing technologies, experimental and analytical approaches for genomic studies, and their myriad applications.

RNA sequencing (RNA - seq) is a genomic approach for the detection and quantitative analysis of messenger RNA molecules in a biological sample and is useful for studying cellular responses.

Sequencing data, combined with skilled bioanalytical approaches and an expert team of gene curators, enables clinicians to access the benefits of the latest genomic advances without having to become technology experts themselves.

Here, we discuss and illustrate the strengths and weaknesses of approaches for the annotation and classification of important elements of protein - coding genes, other genomic elements such as pseudogenes and the non-coding genome, comparative - genomic approaches for inferring gene function, and new technologies for aiding genome annotation, as a practical guide for clinicians when considering pathogenic sequence variation.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.

Paul's research expertise includes: cultivation of marine bacteria, microbial distribution and interactions with marine plants and invertebrates, sequence - based approaches to the discovery of natural products from marine microbes, comparative genomics, microbial chemical ecology, molecular evolution and natural product biosynthesis.

Topics at «Genetics — Moving to the Center of Healthcare» include the role of genomic testing in guiding cancer treatment, approaches to helping families that are coping with genetic diagnoses, and interpretation and use of genomic sequencing results in the newborn population.