Sentences with phrase «genomic studies which»

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But it has been disappointing in that the kind of genetic variation it detects has turned out to explain surprisingly little of the genetic links to most diseases... One issue of debate among researchers is whether, despite the prospect of diminishing returns, to continue with the genomewide studies, which cost many millions of dollars apiece, or switch to a new approach like decoding the entire genomes of individual patients.The unexpected impasse also affects companies that offer personal genomic information and that had assumed they could inform customers of their genetic risk for common diseases, based on researchers» discoveries...

Additionally, the agency would continue efforts to advance precision medicine and cancer genomics in support of the Million Veteran Program (MVP), which aims to collect blood samples and health information from one million veteran volunteers to study how genes affect health.

Gaucher works within the Evogenics Focus Group, which attempts to interpret genomic information from a historical or evolutionary perspective in order to study the origin and adaptation of life on Earth, and perhaps other planets.

I was studying a handful of families in which people had inherited a recessive disease affecting platelet aggregation, looking for mutations in their genomic DNA.

While previous studies have surveyed the genomic characteristics of tumors confined to the prostate gland, the new study is the first to focus on metastatic hormone resistant prostate cancers, which can be difficult to treat because they often develop resistance to standard treatments.

A genome - wide association study (GWAS) of 1570 Africans identified variants significantly associated with skin pigmentation, which clustered in four genomic regions that together account for almost 30 % of the phenotypic variation.

Dr Sid Banka from the Manchester Centre for Genomic Medicine at The University of Manchester, led a team of researchers on the study which is published in Annals of Rheumatic Diseases journal.

Burke, whose lab studies the genomic basis of evolutionary divergence within the sunflower family, was involved in the genetic mapping upon which the genome assembly was based and oversaw the whole genome re-sequencing of the 80 sunflower lines described in the paper.

So the researchers used the genomic data to synthesize the relevant bits of DNA and inserted them into Escherichia coli and Bacillus subtilis, which can both be grown and studied in the lab.

«First, there is no single road map to eusociality — the complex, cooperative social system in which animals behave more like superorganisms than individuals fending for themselves,» said Gene Robinson, a lead on the study who is a professor of entomology and director of the Carl R. Woese Institute for Genomic Biology at the University of Illinois.

For the study, which was published in Nature Communications, the group performed whole genomic sequencing on 30 individual tumors classified as liver cancer displaying a biliary phenotype.

«When you start to do systematic studies of biological systems and you gather information from different angles — meaning genomics, proteomics, and other approaches — and combine this information, you end up being able to do discoveries which would not be possible under each individual set of information,» says Figeys.

The oat crown rust genomics study compared two strains from North Carolina and South Dakota with different virulent profiles which were obtained in 2012 as part of the routine USDA - ARS Rust Surveys.

Added Robert Fulton, director of technology development at Washington University's McDonnell Genome Institute, which contributed to the sequencing and analysis of the data: «This research is a great example of the value of comprehensive genomic analyses and the insights that can be gained from thorough, well - designed studies.

The present study showed that the metabolism of colorectal cancer, distinct from that of pancreatic cancer, depended on genomic alterations, which previously have been uncharacterized, and was not restricted to KRAS mutation alone.

By using results of their genomic studies, the team estimated the fraction of cancer cells in which a mutation was likely to occur.

«In addition to having a higher prevalence of triple - negative breast cancers than Caucasian women — something that has been documented in previous studies — we found that African American women with breast cancer had a significantly higher prevalence of the TP53 driver mutation, basal tumor subtype and greater genomic diversity within tumors, all of which suggest more aggressive tumor biology,» says Tanya Keenan, MD, of the MGH Cancer Center, lead author of the study.

He went on to describe the $ 215 million initiative, which includes new support for cancer genomics and molecularly targeted drug trials at the National Cancer Institute (NCI), and a plan to study links among genes, health, and environment in 1 million Americans by pooling participants in existing cohort studies.

«Our findings suggest that we can quickly and reliably identify whether an infant has a bacterial infection or not by analyzing RNA biosignatures, which are genomic markers of the child's immune response,» said Elizabeth Powell, MD, MPH, study co-author and emergency department physician at Ann & Robert H. Lurie Children's Hospital of Chicago, as well as Professor of Pediatrics at Northwestern University Feinberg School of Medicine.

In 2015, Thijs Ettema and colleagues published a breakthrough study in which genomic data was described of «Loki», an archaeon living in the ocean floor that represented the closest living micro-organism of complex cellular life.

Furthermore, the large volume of data obtained from their study, which was deposited into a public genomics data repository, provides a wealth of information available to other researchers to accelerate ALS research.

Additional studies in which we more precisely define the mechanisms of resistance and growth in an individual's tumor with genomic sequencing, and other means, will be important to maximize the ability to target all the critical pathways to achieve greater success.»

The new study, which was published online today in the journal Molecular Ecology, finds that fungal organisms reduce their core genomic makeup while coalescing with algae to form a lichen partnership, one presumed to be «obligate» (i.e., requiring both partners) but had previously lacked direct genetic verification.

Research builds on a series of recent landmark studies, at JCVI, which have led to transformative new methodology for synthetic biology and functional genomics

Our trainees have the opportunity to study in 700,000 square feet of state - of the - art laboratory and clinical research space, including the Genomic Medicine Institute, which is helping Cleveland Clinic usher in a new era of personalized medicine.

Unlike Internet data, which is formatted relatively uniformly, the diverse sets of genomic data makes it difficult for people to use them across datasets, the study says.

So far, Complete Genomics, Agilent Technologies, Illumina, and Nature Genetics have agreed to sponsor the event, which will be co-organized jointly with the Center for Arab Genomic Studies.

To help plug this diagnostic hole, Rebecca is leading the OCCAMS trial, a CRUK - funded multicentre study which is part of the International Cancer Genome Consortium (ICGC) global project to generate a comprehensive catalogue of genomic abnormalities in 50 tumour types.

Researchers in NCI's Division of Cancer Epidemiology and Genetics (DCEG) integrate tissue profiling into studies examining the causes of cancer to better understand the process by which normal cells are transformed into cancer cells (carcinogenesis) and to pinpoint factors associated with risk for developing specific molecular or genomic subtypes.

The study identifies 60 genomic regions associated with birth weight, most of which had not previously been identified.

For such study, we have used the McGill - R - Thy1 - APP transgenic rat, which is unique compared to other rodent models in that the AD - like phenotype has been achieved with a single genomic insertion of a mutated human APP transgene; minimizing off - target genetic corruption and therefore being closer to the human disease [32].

The study, integration and analysis of these data increasingly allows to unravel the genetic mechanisms and networks underlying complex biological phenotypes paving the way for an era of «genomic medicine,» in which new diagnostic and therapeutic approaches to common multifactorial conditions are emerging.

Further, the authors politely notified representatives of the funding organizations involved before the study came out, giving them an opportunity to (1) take immediate action to strengthen privacy of CEPH samples, and (2) write an opinion piece on the complexities of genomic identifiability, which appears in the same issue of Science.

«PTEN is a genomic marker we already routinely measure, and based on published data we wanted to know if we could use it to predict which BRCA1 / 2 mutated tumors are likely to respond to checkpoint inhibitors and which are not,» said the study's senior author

Nicolas E. Buchler of Duke University and Center for Genomic & Computational Biology, coauthored the study, which appears today in the journal Royal Society Interface.

«PTEN is a genomic marker we already routinely measure, and based on published data we wanted to know if we could use it to predict which BRCA1 / 2 mutated tumors are likely to respond to checkpoint inhibitors and which are not,» said the study's senior author Katherine L. Nathanson, MD, deputy director of the Abramson Cancer Center and director of Genetics at the Basser Center for BRCA.

Most receptors are annotated from comparative genomic studies [8], which means non-coding UTRs are frequently missing.

Dr. Talkowski has performed seminal studies to introduce high - resolution genomics techniques to delineate the types of genetic variation that were classically defined using cytogenetic methods, which has discovered new classes of complex genomic variation in the human genome that are remarkably common yet otherwise cryptic to conventional technologies.

Ching Lau of Baylor presented genomic studies of medulloblastoma (MBM), which accounts for 20 % of all brain tumors and has a 60 % survival rate.

This study reports the nature, levels, diversity, and genomic context of the antimicrobial resistance of human C. difficile isolates from the NAPCR1 / RT012 / ST54 genotype, which caused an outbreak in 2009 and is endemic in Costa Rican hospitals.

«The new studies complement the current GTEx project in assessing genomic variation and gene expression,» explained Simona Volpi, Pharm.D., Ph.D., GTEx program director in the Division of Genomic Medicine at the National Human Genome Research Institute (NHGRI), which helps administer the pgenomic variation and gene expression,» explained Simona Volpi, Pharm.D., Ph.D., GTEx program director in the Division of Genomic Medicine at the National Human Genome Research Institute (NHGRI), which helps administer the pGenomic Medicine at the National Human Genome Research Institute (NHGRI), which helps administer the program.

Genomic studies, which in principle group together co-regulated genes, can potentially identify new components of known regulatory pathways in ES cells that can subsequently be explored in functional studies.

By focusing on a specific set of case studies to which genomic techniques might be applied we will be able to drill down on these scientific challenges but also open the larger conversation about the rights and responsibilities of these new technologies.

Studies on this poop - loving insect revealed the phenomenon of genomic imprinting, in which genes are turned on or off depending on whether they were inherited from the father or the mother.