Can big data and
genomic virus sequencing help us track emerging diseases, contain their spread and ultimately find antidotes for the next unknown pathology?
Not exact matches
We also
sequenced 35 samples from suspected EVD cases that tested negative for EBOV;
genomic analysis identified other known pathogens, including Lassa
virus, HIV - 1, enterovirus A, and malaria parasites (fig.
Using a specially designed computational tool as a lure, scientists have netted the
genomic sequences of almost 12,500 previously uncharacterized
viruses from public databases.
In the largest measles
genomics project to date, the scientists performed DNA
sequencing for 27 different measles
viruses.
Researchers put aside scientific rivalries and within weeks not only discovered the coronavirus that was responsible but also mapped the
virus's
genomic sequence.
However,
genomic sequencing, combined with epidemiological investigation, indicated that the cases did not represent a re-introduction from a neighboring country, but instead were the result of
virus transmission from a «persistently infected» source within Liberia — meaning, for example, a disease survivor who continued to carry the
virus for several months.
Genomic sequence data will be generated from the diverse subtypes / strains (H1 - H16, N1 - N9) in avian reservoirs, which are a source of
viruses with pandemic potential (e.g., H5N1).
Michael Katze, co-host of today's session on
virus - host interactions and
genomics and a member of the project's steering committee, said that the company Illumina has been doing the
sequencing for the project for free, and that just 18 months after the project was launched, the transcriptomes of five species are done.
Genomic sequencing of the isolated
virus revealed that it is closely related to Tembusu
virus (a mosquito - borne Ntaya group flavivirus), with 87 — 91 % nucleotide identity of the partial E (envelope) proteins to that of Tembusu
virus and 72 % of the entire genome coding
sequence with Bagaza
virus, the most closely related flavivirus with an entirely
sequenced genome.
The
virus was also successfully recovered from the infected ducks and confirmed by reverse transcription (RT)- PCR and
genomic sequencing in subsequent experiments.
The Swedish Biodiversity Program aims to target biodiversity of bacteria,
viruses, archaea and eukaryotes and combinations thereof to promote large research projects aiming to uncover and understand
genomic variability in nature by use of massively parallel
sequencing and microbial single cell analysis.
As its name suggests, the XMRV
genomic sequence is closely related to that of the MLVs (murine leukaemia
viruses).
She was a postdoctorate fellow at the National Institute of Allergy and Infectious Diseases / NIH before joining the Institute for
Genomic Research (TIGR; now the J. Craig Venter Institute) where she initiated the
Virus Genomics group and led the Influenza Genome
Sequencing Project funded by NIAID.
Nanopore
sequencing, a novel
genomics technology, has potential applications for routine biosurveillance, clinical diagnosis, and outbreak investigation of
virus infections.