Sentences with phrase «genomics approach identifies»

Not exact matches

The goal is to identify the genes necessary to install C4 photosynthesis in rice through different approaches, including genomic and transcriptional sequence comparisons and mutant screening.

A more useful approach, he says, would be to find a way to make genomic data public without allowing individuals to be identified.

The genomics approach to identifying nematodes and bacteria is a major breakthrough.

«Using innovative data normalization and gene selection approaches, we combined the statistical power of multiple genomic studies and masked their variability and batch effects to identify robust early diagnostic biomarkers of pancreatic cancer,» said first author Manoj Bhasin, PhD, Co-Director of BIDMC's Genomics, Proteomics, Bioinformatics and Systems Biology Center and Assistant Professor of Medicine at HMS.

Identifying how genomic islands move and their effect on bacterial physiology could lead to new approaches to bypass bacterial defenses, Hudson said.

This «next - generation sampling» approach of pairing genomics with large - scale herbarium sampling showed considerable promise as sufficient data were obtained for 98 % of samples, data which identified genetic groups that frequently matched morphologically defined species.

«We're confident that applying this same approach to a lot of new data will help us discover additional genomic variations and identify specific genes that play a role in schizophrenia and other psychiatric conditions.»

Also today, NHGRI and the National Cancer Institute (NCI), both part of the National Institutes of Health (NIH), announced that all three sequencing centers will devote a significant part of their efforts to The Cancer Genome Atlas (TCGA) Pilot Project, which is testing the feasibility of a large - scale, systematic approach to identify important genomic changes involved in cancer.

To accomplish this, I take a functional genomics approach to identify novel genes important for testes development and function.

By analyzing the role of PPARγ in dendritic cells using molecular, genomic, and pharmacologic approaches, we identified genes and gene networks regulated by this receptor.

His group also uses novel genomics approaches to identify genes related to flavor and disease resistance.

Sarah and collaborators at OUCRU are also using a genomic approach to identify protective mechanisms of immunity to severe malaria as part of MalariaGEN Consortial Projects 1 and 2.

There was strong support for the potential to develop and apply novel genomic approaches to addressing the identified conservation issues.

Also here, we employ culture - independent genomics approaches to identify microbial lineages that might have played a pivotal role in this enigmatic event.

Using genomics approaches, Dr. Nobrega has identified the gene IRX3 as the strongest association to polygenic obesity in humans, and characterized the mechanisms by which mutations altering the expression of a gene called TCF7L2 also represent the strongest genetic link to type 2 diabetes in humans.

In particular, I have initiated a team approach that is identifying and studying recurrent, treatment - refractory cancers in our clinics using these approaches as a component of evidence - based diagnostic medicine, seeking to better understand the genomic drivers in these cancers and to identify novel treatment approaches that target them, in hopes of obtaining durable responses.

I primarily use genomic approaches to address these, and over the last few years my group has used large - scale population genomics to identify the global origin and routes of spread of many human and animal pathogens.

Areas of focus include: understanding how tumour - reactive T cells and B cells promote patient survival in cancer; defining the effects of standard treatments on tumor immunity; and using genomic approaches to identify novel tumour mutations that can serve as target antigens for immunotherapy.

Liaison between clinical and basic sciences can be utilized to achieve this, including maximizing the potential of genomic data to tailor individualized treatments, collecting natural history information to identify disorder - specific management requirements, developing new therapeutic approaches through improved knowledge of molecular pathways and protein network interactions, and testing potential new drugs via well - conducted clinical trials.

As part of an ongoing functional genomic screening approach, we have been using microarray analysis and next generation sequencing to identify mouse genes that are specifically expressed in meiosis, and are likely involved in aspects of chromosome biology that are required for meiotic ploidy reduction.

In their laboratory they use genomic, genetic and biochemical approach to identify the genes which fall under circadian rhythm regulation in various organs in our body and to delve into what goes on behind that regulation.