Sentences with phrase «germ line transmission»

The Perfect Host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells.

Our combined in vitro and in vivo expertise shapes a broad portfolio of design (ES cell, CRISPR / Cas9, random DNA insertion), breeding and associated services to create and maintain the most relevant models for your studies.Rely our industry - leading germ line transmission, strict quality controls, fast turnaround and dedicated project managers to help you successfully reach your goals.

The establishment of the genetically modified mouse line by breeding with the chimeric mice (Germ Line Transmission (GLT) of the mutation)

These findings provide evidence for germ line transmission of an extragenic sequence - specific silencing factor and implicate rde - 1 and rde - 4 in the formation of the inherited agent.

Not exact matches

Our partner, Dan Snyder of Grouse Park, clearly demonstrated that a small flock of Greater Prairie Chickens can produce the ideal amount of fertile eggs for germ - line transmission research.

We are currently raising funds for the next part of our Phase 2 research: resuming germ - line transmission research in spring 2018, drawing upon lessons learned from our previous research and making the appropriate modifications.

These birds will be crucial to the future stages of germ - line transmission research that require extensive handling of captive birds.

We concluded that an expanded Revive & Restore, in partnership with biotech organizations, will be able to offer services that include Genetic Insight (DNA sequencing and analysis), Biobanking (tissue collection and cell culturing), Advanced Reproductive Services (cloning and germ - line transmission), and Genome Engineering (CRISPR, gene - drive, etc.) Applications include restoring genetic diversity, augmenting adaptation to climate change, conferring resistance to disease, and extirpating harmful invasive species.

A particular developmental stage of germ - cells is required for germ - line transmission to work, which is the earliest stage known as «primordial germ cells.»

The knowledge gained and resources developed in 2016 will allow us to refine the process of isolating germ cells, bringing Revive & Restore closer to achieving our goal of hatching Greater Prairie Chicken offspring via germ - line transmission, the first major step toward hatching a new generation of Heath Hens.

This must be accomplished by using a process known as germ - line transmission, where the primordial germ cells (PGCs) of an early embryo are edited, grown in cultures, and then reproductively transmitted through surrogate host parents to generate live, engineered birds.

Once we can culture primordial germ cells and optimize germ - line transmission for Domestic Rock Pigeons, we can transfer those techniques to the Band - tailed Pigeon.

This can only be accomplished by germ - line transmission, a process we have started to develop for Greater Prairie Chickens.

This could potentially improve the efficiency of successful and ubiquitous editing of the embryo's cells, increasing the germ - line transmission rates of this method of avian genetic engineering.

Advanced reproductive techniques such as artificial insemination, culturing of primordial germ cells for germ - line transmission, stem cell embryogenesis, and cloning offer an array of new ways to expand and even infuse lost and new genetic variability into at - risk wildlife populations.

The ideal method to engineer bird genomes is germ - line transmission via cultured primordial germ cells.

EMMA strains produced from ES cells generated by the International Knockout Mouse Consortium (IKMC) are displayed on the EMMA strain list as soon as germ - line transmission has been achieved and the genotype of the pups has been confirmed.

His pioneering mouse embryonic stem (ES) cell work in the 1980s, demonstrating germ - line transmission and the great potential of ES cells to generate mice carrying mutations in endogenous genes, established milestones in a field that saw the award of the 2007 Nobel Prize in Physiology or Medicine to Mario Capecchi, Martin Evans, and Oliver Smithies.