Sentences with phrase «germline cells»

In germline cells PIWI proteins silence the RNA from jumping genes by cutting them in sequences of ~ 30 nucleotides that will become piRNAs.

Tina Hesman Saey covered researchers» arguments for and against this type of genetic engineering in «Editing human germline cells debated» (SN: 5/30/15, p. 16).

It is known that the ATM protein is one of the main proteins involved in DNA repair in somatic cells (any of the cells forming part of our organism, except for germline cells).

At the beginning of meiosis, germline cells intentionally generate multiple double chain breakages along the whole DNA genome.

This discovery suggests that autophagy has to be finely controlled in surrounding tissues to ensure germline cell homeostasis.

The researchers found that too much or too little activity by the autophagy protein BEC - 1 in neurons, muscles and the intestine is detrimental to germline cell proliferation.

«Vasa, like LOTUS, is widely found in other organisms, including animals, so it could be that this interaction isn't specific to the fruit fly but also takes place in other germline cells,» says co-researcher, Mandy Jeske.

The mice grew teratomas, a kind of tumor that grows from germline cells and which contains many types of tissues.

These genes are expressed in many tumors and are silent in normal tissues except male germline cells.

Altering DNA in germline cells — embryos, eggs, and sperm, or cells that give rise to them — may be used to cure genetic diseases for future generations, provided it is done only to correct disease or disability, not to enhance people's health or abilities, a report issued February 14 by the National Academies of Sciences and Medicine recommends.

Germline cells are labelled «immortal»: they have reproduced indefinitely since the beginning of life.

This held true whether the genome modification was in germline cells, which can be passed on to offspring, or in somatic cells that can not.

A mutagenesis strategy autocatalytically converts mutations to the homozygous condition in fly somatic and germline cells.

In Drosophila, we found that MCR mutations efficiently spread from their chromosome of origin to the homologous chromosome, thereby converting heterozygous mutations to homozygosity in the vast majority of somatic and germline cells.

But if an APOBEC protein was active in germline cells — those destined to become eggs and sperm — then these mutations could possibly affect future generations, and ultimately alter the course of evolution.

In mammals, germline cells are the sperm and ova (also known as «gametes») which fuse during fertilization to produce a cell called a zygote, from which the entire mammalian embryo develops.

There is considerable interest in using this tool in somatic cells — to develop cell - based therapeutics, for example — as well as in germline cells, the focus of this statement and an ethically more complex issue because of potential effects on not just the treated individual but also future generations.

In prior work in fruit flies, Haase, Hannon and others demonstrated that when Zucchini was not expressed, single - stranded RNAs that are the precursors for functional piRNAs accumulated in germline cells.

The Largaespada lab has invested heavily in the use of a vertebrate - active transposon system, called Sleeping Beauty (SB), for insertional mutagenesis in mouse somatic and germline cells and for gene therapy.

However piwi, while expressed in both somatic and germline cells, is required in the terminal filament for stem cell maintenance but is also needed for cell division in the germline.

It is always possible that a vector will introduce the gene into a cell other than that for which it is supposed to be targeted (e.g., a spermatocytic cell) or that through a secondary mechanism target cells that have taken up the new gene will through some independent natural process (such as transfection) transfer the gene to a germline cell.