Some of the concerns raised about somatic gene transfer are related to the possibility that it could inadvertently lead to
germline gene transfer.
Beyond the medical risks to the potential child, a number of long - standing ethical concerns exist regarding the possible practice of
germline gene transfer in both human and nonhuman cases.
In
germline gene transfer, the parents» egg and sperm cells are changed with the goal of passing on the changes to their offspring.
Germline gene transfer is not being actively investigated, at least in larger animals and humans, although a great deal of discussion is being conducted about its value and desirability.
Not exact matches
It is always possible that a vector will introduce the
gene into a cell other than that for which it is supposed to be targeted (e.g., a spermatocytic cell) or that through a secondary mechanism target cells that have taken up the new
gene will through some independent natural process (such as transfection)
transfer the
gene to a
germline cell.