Sentences with phrase «germline stem cells»

«Scientists describe a function for autophagy in germline stem cell proliferation.»

Scientists have previously shown that isolated germline stem cells from mice can turn into eggs in a petri dish.

In contrast, forced expression of upd within niche cells delayed the loss of germline stem cells in older males.

While male germline stem cells differentiate (or become specialized) throughout a man's life to produce a steady supply of new sperm, a woman's are believed to differentiate into a stockpile of eggs during a relatively narrow time frame before she's even born.

In the current issue of the journal Nature, scientists at the Stowers Institute for Medical Research report that competition between two proteins, Bam and COP9, balances the self - renewal and differentiation functions of ovarian germline stem cells (GSCs) in fruit flies (Drosophila melanogaster).

The study also found that in addition to its role in determining the sex of somatic cells, Sxl regulation by m6A is required to initiate germline stem cell differentiation for developing eggs.

Developmental biologist Ji Wu and her colleagues at Shanghai Jiao Tong University in China took germline stem cells from the ovaries of a 6 - day - old mouse, cultured them in a petri dish, and then transplanted those cells into the ovaries of sterilized adult mice.

EGG - CITING DEVELOPMENT Germline stem cells (orange circles, left) implanted into a mouse's ovary move to the edge of the ovary (middle) and begin developing into eggs.

It's also additional evidence that germline stem cells collected after a female mammal is born can still turn into viable eggs, Telfer says.

Tracing and characterizing the development of transplanted female germline stem cells in vivo.

«In our studies, we wanted to find out the nature, if any, of the relationship between germline stem cells and the gene Abd - B,» states Prof. Lohmann, who further explains that Abd - B belongs to a family of developmental genes referred to as Hox genes.

Using the Drosophila melanogaster fruit fly as a model organism, the team led by Prof. Dr. Ingrid Lohmann at Heidelberg University's Centre for Organismal Studies was able to show how a special developmental gene from the Hox family influences germline stem cells.

The apical tip of fruitfly testis containing germline stem cells and differentiating germ cells.

Using this method, the authors discovered that germline stem cells inherit specific copies of Y (and X) chromosomes.

The accumulation of only adult stem cell - like cells indicates a mutation in the master differentiation factor bam completely blocks germline stem cell lineage differentiation.

Karim Nayernia of the University of Newcastle, UK, and his colleagues treated male embryonic stem cells (ESCs) with a range of substances, which converted them first into germline stem cells and then into spermatogonial stem cells.

The researchers then attempted to see if the cells, which they labeled multipotent adult germline stem cells (maGSC), would differentiate into specific types of body cells.

Sophia Millonigg (Eckmann, MPG)-- «The translational activator complex GLD - 4 / GLS - 1 regulates germline stem cell self - renewal and differentiation in the adult C. elegans germ line» (2013)

Germline; reprinted from Xie T., Germline stem cell niches (September 30, 2008), StemBook, ed.

Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling.

Most recently Loquacious was reported to have a role in germline stem cell maintenance and stellate suppression.

An immunofluorescence image of the tip of the Drosophila testis, showing male germline stem cells and their daughters (green) responding to self renewal signals from the stem cell niche.

The Xie Lab demonstrated that differentiation - defective Drosophila ovarian germline stem cells (GSCs), behaving like human cancer stem cells, can out - compete normal stem cells for a position in the niche.

Germline stem cells from infant mice can restore fertility in sterilised adult mice Finding ways to restore fertility could help many individuals which have become sterile as a result of cancer treatments, in addition to those suffering from an earlier menopause.

These egg - generating cells are germline stem cells — precursors that become either eggs or sperm depending on whether they end up in ovaries or testes.

Isolating those germline stem cells and coaxing them to become eggs has proven tricky, though.

The results show that germline stem cells can indeed restore fertility when transplanted into other mice, Wu says.

Some recent studies have begun to question that conventional wisdom, though the idea that germline stem cells could still exist in women after birth is controversial (SN Online: 7/9/12).

The germline stem cells there produce daughter cells that develop into mature sperms.

This damages their function, which in turn causes the germline stem cells to divide incorrectly.

In the absence of Wnt6 signaling, anterior escort cells die and germline stem cells are lost.

They report in the February issue of Development that support cells called anterior escort cells, located next to the germline stem cells, are a required component of the niche.

PLZF is expressed in germline stem cells and is required for their self - renewal.