With super high reps, you don't
get the myostatin problem or the damage problem.
«By tweaking the dormant state of the molecule, we can
get myostatin to signal without the need for cutting, basically picking the lock without a key.
Not exact matches
Previous researchers may have
gotten GDF11 mixed up with a similar protein called
myostatin, which does dip as people
get older.
After about 48 and 72 hours, even though the satellite cells and the
myostatin levels
got back to their baseline values in the group that ate more protein, the levels remained lower for a longer period in the group that ate less protein.
It requires a lot more energy and does a lot more damage doing say, 10 × 10 (or your 15 × 5), than it does doing one set of 25 - 50 or 50 - 100 reps.. In the end, you
get less hypertrophy with high volume heavy lifting, because a) you still have all that
myostatin buildup from heavy lifting suppressing hypertrophy, b) you don't sufficiently fatigue medium and fast twitch fibers, c) you don't
get the increased IGF - 1 production and increased protein synthesis that you would
get from high reps, and d) because the energy requirements of repairing the damage caused by heavy lifting are too high.
You also have to consider that with heavy lifting, you
get the increased
myostatin production inhibiting muscle growth, and you can't overcome that by simply increasing set volume.
Myostatin is a myokine protein found in the body that serves one purpose: to prevent muscles from
getting larger.