The phrase
"giant viruses" refers to viruses that are unusually large compared to other viruses. They are called "giant" because they have much more genetic material and complex structures, which make them stand out among their smaller counterparts.
Full definition
«I'm quite confident that the current record of the genome size
of giant viruses will be broken,» he says.
Two newly
discovered giant viruses have the most comprehensive toolkit for assembling proteins found in any known virus.
A newfound pair
of giant viruses have massive genomes and the most complete resources for building proteins ever seen in the viral world.
A group of
giant viruses called Mimiviruses was first discovered in 2003, and a handful of such groups have been reported since.
While sifting through metagenomic sequence datasets for a U.S. Department of Energy Joint Genome Institute (JGI) Community Science Program project, researchers identified genome sequences typically found
in giant viruses.
Further searching through the metagenomic datasets uncovered three more related
giant virus genomes.
Using permafrost samples provided by the Russian team, they fished for
giant viruses by using amoebae — the typical targets of these pathogens — as bait.
But after discovering a novel group of
giant viruses with a more complete set of translation machinery genes than any other virus known to date, scientists at the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, believe that this group (dubbed «Klosneuviruses») significantly increases our understanding of viral evolution.
Instead, the team announced in March, they simply warmed the frozen soil and added amoebas, common hosts
for giant viruses.
It also suggests that cell life could have emerged with a far greater variety of pre-cellular forms than those conventionally considered, as the
new giant virus has almost no equivalent among the three recognized domains of cellular life, namely eukaryota (or eukaryotes), eubacteria, and archaea.
Overall, the team's findings lend credence to the theory that
giant viruses evolved from much smaller viruses, rather than aligning with theories that they may instead be descended from a cellular ancestor.
Including information about other viruses and virus - like elements: adenoviruses that infect animals and are one of the causes of the common cold; certain bacteriophages that infect bacteria; transpovirons which
infect giant viruses; and a Tetrahymena transposable element (Tlr1), the virus «evolutionary tree» appears as a network of swapped genes.
Virus length and genome size for a representative from each of two
recognized giant virus families (mimivirus and marseillevirus families) and eight potential families are shown.
Detailed analysis has shown that these first two Pandoraviruses have virtually nothing in common with previously
characterized giant viruses.
Knowing
how giant viruses impact microbial survival and community interactions is relevant to U.S. Department of Energy missions in bioenergy and environment.
The researchers assembled a 1.57 - million base (megabase) genome of a
suspected giant virus they called Klosneuvirus.
Scientists typically don't classify viruses as living organisms, but
giant viruses like these, with their own protein - making machinery and other functions normally carried out in living cells, blur the lines between what's alive and what isn't.
Another — a scenario championed by Koonin — presents the idea that
giant viruses arose from smaller viruses.
Scientists have been fascinated by
giant viruses since 2003, when a group of French biologists led by Didier Raoult discovered the Mimiviruses.
The comprehensive phylogenomic analysis
compares giant viruses that infect amoeba with tiny viruses known as virophages and to several groups of transposable elements.
There is a small news item
about giant viruses infecting zooplankton which affects ocean carbon flows.
«Once again, this group has opened our eyes to the enormous diversity that exists
in giant viruses,» says Curtis Suttle, a virologist at the University of British Columbia in Vancouver, Canada, who was not involved in the work.
The team also found that the Klosneuviruses encoded components for a far more expansive translation system than had been seen with
other giant viruses.
The discovery in 2003 of
giant viruses with hundreds or even thousands of genes shattered the existing definition of living organisms3.
In the article published in Science, the researchers announced they had discovered two
new giant viruses:
One posits that
giant viruses evolved from an ancient cell, perhaps one from an extinct fourth domain of cellular life.
Giant viruses of amoebae: A journey through innovative research and paradigm changes.
The era of
the giant virus began in 2003 with the discovery of the first Mimivirus (SN: 5/23/09, p. 9).
In 2009,
another giant virus called Marseillevirus was identified.
Once unheard of,
giant viruses may be common in water and soils worldwide.
You can even find it in some things that aren't technically alive, such as
the giant viruses known as mimiviruses.
These giant viruses have more protein - making gear than any known virus.
Orpheovirus IHUMI - LCC2: A new virus among
the giant viruses.
With a diameter in the region of a micrometer and a genome incorporating more than 1,100 genes,
these giant viruses, which infect amoebas of the Acanthamoeba genus, had already largely encroached on areas previously thought to be the exclusive domain of bacteria.
In a study led by researchers at the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science user facility, a new group of
giant viruses has been uncovered after sifting through complex genetic datasets.
Dubbed Klosneuviruses,
the giant virus contains a more complete set of translation machinery genes than any other virus known to date.
Aside from increasing the known gene pool of
giant viruses by nearly 2,500 additional gene families, comparing the genes to previously discovered giant viruses revealed that the Klosneuviruses are a subfamily of Mimiviruses.
This is unusual because until now,
all giant viruses had been recovered with Acanthamoeba (amoebas found in soils and fresh waters), which was not seen with the Klosneuviruses.
As their name suggests,
giant viruses are larger than many bacterial and eukaryotic cells.
The finding suggests that Sputnik infects more than one group of viruses and can shuttle genetic material from one
giant virus to another.