Sentences with phrase «given at high doses»

Bacterial infections of the skin can be difficult to treat because many antimicrobial drugs do not reach the skin, and when they do, they need to be given at high doses and for a long time.

Because AML is difficult to treat, standard treatment commonly involves multiple chemotherapy medicines that are given at a higher dose in order to kill the cancer cells.

Not exact matches

Liverpool's high pressing game will come to not in this big PL game because the Gunners have more than prepared themselves to negate whatever the Reds have on offer against them in the game by making themselves bigger in the game than the Reds have imagined by inflicting on them a heavy punishment on the field of play during the playing of the match to make them pay for the sin they've committed against Arsenal by giving them a dose of their own medicine for having the audacity to come to the Emirates Stadium and took away all the 3 points that were at stake in an opening day PL game without at least leave a point for Arsenal to collect in the match..

Preliminary data show that giving children with milk allergies increasingly high doses of milk over time may ease or help them overcome the allergy, but researchers warn it should never be tried at home.

Additionally, I predict that at the completion of our study, despite the higher doses given per treatment in the experimental accelerated, hypofractionated RT arm, there will be no increased toxicity with this regimen.

The effectiveness of leptin at battling diabetes in these animals may have been due to the high doses given, says Laura McCabe, a physiologist at Michigan State University in East Lansing.

Despite the availability of many excellent antibiotics, bacteria are developing resistance to those most commonly used, forcing physicians to give higher doses or fall back to «last line of defense» drugs, said co-senior author Dr. Erdal Toprak, Assistant Professor of Pharmacology and in the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology and a Southwestern Medical Foundation Scholar in Biomedical Research at UT Southwestern.

New research conducted at the Center for Tuberculosis Research at the Johns Hopkins University School of Medicine shows that lower doses of the toxic drug bedaquiline — given together with verapamil, a medication that's used to treat various heart conditions — can lead to the same antibacterial effects as higher toxic doses of bedaquiline.

He says the doses given to the volunteers in the group where the accident occurred were also unnecessarily high, as full inhibition of FAAH occurred at a much lower level.

They report that females exposed to the higher dose of BPS during pregnancy and lactation spent significantly more time on the nest than controls at one observation point, an unexpected finding given that mouse mothers usually spend less time on the nest as pups grow and develop.

«We did see that giving a higher dose of the drug seemed to produce a better methylation response among patients,» says Valerie Lee, M.D., a fellow at the Johns Hopkins Kimmel Cancer Center.

This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.

Influenza remains a major health problem in the United States, resulting each year in an estimated 36,000 deaths and 200,000 hospitalizations.4 Those who have been shown to be at high risk for the complications of influenza infection are children 6 to 23 months of age; healthy persons 65 years of age or older; adults and children with chronic diseases, including asthma, heart and lung disease, and diabetes; residents of nursing homes and other long - term care facilities; and pregnant women.4 It is for this reason that the Centers for Disease Control and Prevention (CDC) has recommended that these groups, together with health care workers and others with direct patient - care responsibilities, should be given priority for influenza vaccination this season in the face of the current shortage.1 Other high - priority groups include children and teenagers 6 months to 18 years of age whose underlying medical condition requires the daily use of aspirin and household members and out - of - home caregivers of infants less than 6 months old.1 Hence, in the case of vaccine shortages resulting either from the unanticipated loss of expected supplies or from the emergence of greater - than - expected global influenza activity — such as pandemic influenza, which would prompt a greater demand for vaccination5 — the capability of extending existing vaccine supplies by using alternative routes of vaccination that would require smaller doses could have important public health implications.

Radiotherapy given in high doses over a shorter period of time is safe and effective for prostate cancer patients, according to research presented at the ESTRO 37 conference today.

Barcelona, Spain: Radiotherapy given in high doses over a shorter period of time is safe and effective for prostate cancer patients, according to research presented at the ESTRO 37 conference today.

Some magnetic resonance techniques can give information about the quantity and function of beta cells, he says, but they use a dose of manganese chloride that is at least 1 million times higher than the new PET technique, suggesting an advantage in lower toxicity.

Because high doses of opioids have the potential to cause respiratory arrest or other dangerous side effects, doctors may hesitate to give patients as much of the drugs as they need to relieve their pain, says David Soergel, chief medical officer at Trevena.

And of those 20 patients, more than half couldn't finish the 12 - week induction regimen because we used the high dose of ipilimumab at 3 mg / kg, whereas nivolumab was given at 1 mg / kg.

December 12, 2011 — Recurrent wheezing in children at risk for developing asthma can be controlled using far less medication by giving higher doses of an inhaled corticosteroid only as needed instead of lower doses every day, a study found.

The trial has a dose escalation design: very low doses were given at first, with later volunteers getting higher doses.

Sodium borate and boric acid interfere with sperm production, damage the testes and interfere with male fertility when given to animals by mouth at high doses.

Embryo - fetal development studies carried out on mice and rats also observed a reduced number of pups per litter, reduced pup weight at birth, and an increased frequency of skeletal «variations» in pups after pregnant females were given high doses of DEP.

One clinical trial carried out at the University of Texas Southwestern Medical Center discovered that roughly 80 percent of those patients who were given a high dose of the plant supplement found that their rheumatoid arthritis symptoms got better considerably making it well worth a try for those looking for natural remedies for inflammation and pain.

Use L - citrulline 10.10.2013 Bodybuilding with protein - rich diet is healthier 24.06.2014 Same amount of protein at every meal gives optimal muscle synthesis 11.06.2014 Animal study: endurance athletes perform best on diet where 20 percent energy comes from protein 03.05.2014 The best high - protein slimming diet contains lots of taurine and glycine 13.04.2014 Extra meat makes strength training more effective 25.03.2014 Optimal post-workout whey dose: 20 g 24.01.2014 Whey or casein before and after your workout?

Clinically, I have seen time and again that if you give humans the nutrients they need at high doses they feel and perform better.

The oral fat load in either low or high dose was given in four equally divided doses at 0, 2, 4, and 6 h.»

It should be stated that titamin B12, Folic acid and Pyridoxine have a central role in cell growth and energy production and have given rise speculation that these vitamins may increase the promotion of carcinogenesis and enhance the growth of cancer cells at high doses.

Given the relatively low academic skills and high poverty rates of double - dosed CPS students, it is unsurprising that double - dosing improved college enrollment rates at relatively inexpensive and nonselective two - year postsecondary institutions.

Although Buick says a healthy dose of high - strength steel has helped shed 300 pounds from the old LaCrosse, the combo of a V - 6 engine and AWD hardware gives the sedan a feeling of heft, with the AWD model weighing in at 3,840 pounds.

If given at an inappropriate dose, NSAIDs can cause adverse effects in both humans and pets, but these effects tend to the be much more severe in dogs and cats due to the way that their bodies metabolize NSAIDs and because they are more likely to receive a high dose of the drugs — taking into consideration the OTC pills are made for humans and not pets.

(Note: the right dose of these nutritional supplements should be established in consultation with the veterinarian, since some of them — namely vitamin A, selenium and iron — can be toxic when given at relatively high levels).

Initially 2 doses, given 3 - 4 weeks apart; Further booster required every year for felines at high risk

It is a technique used by physicians that fight kidney rejection and autoimmune diseases of many sort — give multiple drugs at lower doses rather than single drugs at high doses.

Never give an arthritis / pain control medication at higher than the suggested dose.

Cyclophosphamide use may increase the risk of bladder cancer later in your pet's life Unneutered males male develop sterility Toxic to the heart at high doses Lung damage is possible If you notice any of these symptoms or anything else unusual, contact your veterinarian Can this drug be given with other drugs?

Anti-seizure doses are three to ten times higher than analgesic doses at least to start and, at least in dogs, gabapentin must be given 3 - 4 times daily.

This could be a problem in patients with congestive heart failure or other patients who require sodium restriction May stunt growth if used in young, growing animals May lower seizure threshold and alter mood and behavior At high doses, this medication can cause birth defects early in pregnancy, be irritating to the stomach or cause higher than normal blood sugar levels If your pet has received high doses, it should not be vaccinated without your veterinarian's advice as the vaccine may not work or it may actually give your pet the disease you are trying to prevent Less common side effects include weight gain, insomnia, panting, diarrhea, vomiting, elevated liver enzymes, pancreatitis and behavior changes Serious side effects are not expected with routine use.

Side effects are rare for ivermectin given at heartworm preventive doses Considered to be safe in pregnant and nursing animals Problems may arise at high doses in some dogs, especially Collies, Australian Shepherds, Old English Sheepdogs, Shelties and any of these crossbreed dogs.

Restlessness or caffeine - type jitters, dizziness, fast heartbeat, stomach ache and possible seizures at high doses Seizures can occur in patients with prior seizure history If your pet shows any of these symptoms, is especially restless or you notice anything else unusual, contact your veterinarian Can this drug be given with other drugs?

Sedation, drowsiness, incoordination Cats: may experience irritability, depression, incoordination and difficult breathing at high doses If you notice anything unusual, contact your veterinarian Can this drug be given with other drugs?

Typically, we give corticosteroids to control pemphigus diseases, at pretty high doses.

You can also continue the oral glucosamine supplementation with a high - quality supplement such as Cosequin; I know owners of large dogs who say they have been able to extend the symptom - free period between Adequan injections to as much as six months by starting out aggressively, and tapering off while giving oral glucosamine supplements at the highest recommended dose.

Liver cell destruction (hepatocellular necrosis), ingestion of toxic products, tainted foods or medications (such as giving Tylenol to cats, medications at too high a dose or a unique reaction to a medication that your veterinarian could not have predicted), lack of liver blood supply (hepatic hypoxia), congestive heart failure and bile duct obstruction can all cause elevated GDH levels in your pet.

«We know what doses the animals were given, and when we look at humans, we see blood levels within that range or actually higher, which is a cause of concern and should stimulate more human research,» said Jerrold Heindel of the National Institute of Environmental Health Sciences.

The finding comes from scientists at the University of Rochester Medical Center who recommend women should be given high doses of vitamin D.