Sentences with word «glaucomatous»
This research was prompted by Dr. Townsend's observation of one affected dog (that lost one eye to GRPU) undergoing spontaneous resolution of GRPU (i.e. resolution of pigment deposition on the ALC) in its remaining eye while on daily specific antioxidant supplementation; this supplement has been shown to be neuroprotective in the presence of glaucoma, and thus may help preserve vision (and help preserve optic nerve function) in glaucomatous eyes.
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There are other surgical choices for blind glaucomatous eyes (see Glaucoma).
Overall, this simple technique (see figure for overview) produces therapeutically relevant cells in a safe and efficacious manner, which may be used in in vitro models for the investigation of glaucoma disease mechanisms, RGC development, drug testing, and may in the future lead to a treatment of glaucomatous neuropathy.
Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy.
Review of «Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy» from Stem Cells by Stuart P. Atkinson
Induced autoimmunity to heat shock proteins elicits glaucomatous loss of retinal ganglion cell neurons via activated T cell - derived Fas - ligand Wax, M.B., Tezel, G., Yang, J., Peng, G., Patil, R.V., Agarwal, N., Sappington, R.M. & Calkins, D.J. (2008) Journal of Neuroscience, 28:12085 - 12096.
I have been working in the field of glaucoma research, on pathophysiology and diagnostics, for the past 18 years, and have become increasingly interested in the use of advanced imaging techniques for characterization of glaucomatous changes within the retina and optic nerve head.
We hypothesize that an early estrogen deficiency accelerates the aging of the optic nerve and predisposes this nerve to glaucomatous damage.
Distal axonopathy with structural persistence in glaucomatous neurodegeneration Crish, SD., Sappington, R.M., Inman DM., Horner, PJ.
W. Daniel Stamer, PhD Duke University Eye Center, Durham, NC Funded by The Alcon Foundation Project: Role of Exosomes in Glaucomatous Lamina Cribrosa Remodeling
Still other researchers are working with RPB grants to promote optic nerve regeneration, to study changes in trabecular meshwork gene expression about a decade before risk of the disease starts going up, and to determine if abnormal blood flow is an important factor in causing glaucomatous optic nerve damage.
(2006) Induced Autoimmunity to Heat Shock Proteins Elicits Glaucomatous Loss of Retinal Ganglion Cells via a FAS / FAS - Ligand Pathway (Investigative Ophthalmology & Visual Science, 47: ARVO E-Abstract 1828).
Soto, I., Son, J., Marsh - Armstrong, N (2008) Proliferation and Oligodendrocyte Turnover in Optic Nerves of Glaucomatous DBA / 2J Mice.
Association of blood and ocular perfusion pressure with structural glaucomatous progression by flicker chronoscopy.
Surgical treatment for blind glaucomatous eyes must be performed if glaucoma can not be controlled medically, because these dogs are in constant discomfort (similar to a migraine headache) and the eye (s) are enlarging because of the increased internal pressure.
BACKGROUND Vascular risk factors have been associated with glaucomatous visual field progression.
Dr. Zangwill's research focuses on improving our understanding of the complex relationship between structural and functional change over time in the aging and glaucoma eye, developing computational and statistical techniques to improve glaucomatous change detection, and identifying risk factors that can predict rapidly progressing glaucoma.
We discovered in the laboratory, our lab and others, that mitochondria — these are the little energy powerhouses inside the cells, inside all cells including retinal ganglion cells — they fragment and stop moving in retinal ganglion cell axons very early in glaucomatous insults.
Moreover, metabolic reprogramming is a common hallmark in cancer, and emerging evidence suggests that a metabolic alteration may also be present in early glaucoma, including a change of oxygen consumption in glaucomatous retina.
Project: Systemic Delivery of a Neuroprotective Agent to Protect against Glaucomatous Cell Death in the DBA2 / J Mouse
For many glaucomatous patients, however, pharmacological and surgical management of IOP does not always help.
In some patients IOP reduction is difficult to accomplish or glaucomatous vision loss occurs despite substantial IOP reduction.
Summary: The goal of this project is to better understand the mechanisms involved in glaucomatous injury to the eye.
These proteins, if their roles in neuroprotection in the retina are fully established in the future by more comprehensive studies, may present novel therapeutic targets in treating retinal disorders including glaucomatous conditions.»
We observed that exosomes from glaucomatous lamina cribrosa cells were different than exosomes from normal cells.
Metabolic Vulnerability Disposes Retinal Ganglion Cell Axons to Dysfunction in a Model of Glaucomatous Degeneration Baltan, S., Inman DM., Danilov, CA., Morrison, RS., Horner, PJ.
Summary: We hypothesize that early estrogen deficiency accelerates optic nerve aging and predisposes this nerve to glaucomatous damage.
The published paper concluded that» «molecular alterations detected in the ocular hypertensive human retina as opposed to previously detected alterations in human donor retinas with clinically manifest glaucoma suggest that proteome alterations determine the individual threshold to tolerate the ocular hypertension - induced tissue stress or convert to glaucomatous neurodegeneration when intrinsic adaptive / protective responses are overwhelmed.»
Glaucomatous optic nerve injury involves early astrocyte reactivity and late oligodendrocyte loss.
Marsh - Armstrong N, Cox E, Soto I. (2008) Gamma synuclein changes cellular distribution in glaucomatous DBA / 2J mice (Investigative Ophthalmology & Visual Science, 49: ARVO E-Abstract 5490).
The best options for a blind, glaucomatous eye are intraocular prosthesis, enucleation, or intraocular injection (ciliary ablation).
Tara Tovar - Vidales, MS, PhD University of North Texas Health Science Center, Fort Worth, TX Funded by The Alcon Foundation Project: Role of microRNAs (miRNAs) in Pathologic Fibrosis in the Glaucomatous Optic Nerve Head
Because Golden Retrievers are wonderful, uncomplaining dogs, they will not usually let their owners know that their glaucomatous eyes are bothering them.