Sentences with phrase «glia into»
In vivo conversion of Müller glia into photoreceptors through cell fusion - mediated reprogramming.
http://piacosmalab.com/
«Regenerative potential of cells in mouse retina: Researchers use a clue from zebrafish to discover the cues that reprogram Müller glia into retinal neurons.»
Not exact matches
Glia - making cells from people with schizophrenia also mostly failed to turned into astrocytes, which help neurons connect and determine when those connections, or synapses, fire.
A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice.
Notably, the majority of cells that converted into neurons were NG2 glia.
Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.
They turn into another kind of glia, called astrocytes.
«Our study is the first to demonstrates unambiguously the conversion of a specific subtype of glia, the so - called NG2 glia, into induced neurons in living animals,» says senior study author Benedikt Berninger of Johannes Gutenberg University Mainz.
Understanding the coordinated development of motor neurons and glia may inform ways to prod stem cells into generating more glia after someone suffers an injury with nerve damage.
«APOE2 and APOE3 can effectively transfer lipids into glia,» Liu said.
Reh said his team hopes to find out if there are other factors that can be activated to allow the Müller glia to regenerate into all the different cell types of the retina.
With PAR3 out of the picture, neural stem cells and progenitors are free to differentiate into new neurons and glia.
The researchers donned their thinking caps to explain how neural stem and progenitor cells differentiate into neurons and related cells called glia.
The gene activity profiles also provided several novel insights into the biology of outer radial glia.