Sentences with phrase «glia showed»

They found that when microglia were also lost, Müller glia showed almost no regenerative activity after three days of recovery, compared with approximately 75 percent regeneration in the control population.

Not exact matches

A study in the International Society for Stem Cell Research's journal Stem Cell Reports, published by Cell Press on November 20 shows that a Sox2 protein, alone or in combination with another protein, Ascl1, can cause nonneuronal cells, called NG2 glia, to turn into neurons in the injured cerebral cortex of adult mice.

Berninger and others have previously shown that Sox2, Ascl1, and other transcription factors — proteins that bind to specific DNA sequences to control the activity of genes — can induce the nonneuronal «support cells» known as glia to turn into neurons.

«We're showing for the first time that Müller glia in the adult mouse can give rise to new neurons after injury, and these neurons have the gene expression pattern, the morphology, the electrophysiology, and the epigenetic program to look like interneurons instead of glia,» Reh said.

The study of these models shows that proteins MCL1 and GlialCAM play a crucial role in localization and regulation of chloride channel CLC - 2 in the glia, and proves that the channel is involved in the disease.

Analyses of genome structure further shored up evidence that the cells that were once Müller glia had been genetically reprogrammed and were now showing characteristics of interneurons.

«This study for the first time shows increased expression of IL - 33 in AMD and further demonstrates a role for glia - derived IL - 33 in the accumulation of myeloid cells in the outer retina, loss of photoreceptors, and functional impairment of the retina in preclinical models of retina stress,» the authors note.

An image of tissue that's grown in a dish shows radial glia stem cells that are red, neurons in blue and the AXL receptor in green.

Early in his career, he discovered that previously enigmatic support cells, known as radial glia, serve as guides for the migration of cortical neurons in the developing brain, and showed how this process is critical for the organization of the multi-layered structure of the cerebral cortex.

Together these studies show that the responses of both retinal ganglion cells and surrounding glia are involved in the pathogenesis of glaucoma.

Here, we show that BACE2 is expressed in discrete subsets of neurons and glia throughout the adult mouse brain.