The problem with the typical
gliadin antibody test is that it only tests alpha gliadin.
Not exact matches
They're typically given the
gliadin or anti-transglutaminase
antibody tests.
For this reason, I use Cyrex Lab in my clinic because they have a
test that looks at the
gliadin sub-fractions, which helps to minimize false negatives that can be found with the IgA and IgG anti-
gliadin antibody testing.
Other blood
tests are deamidated
gliadin and
gliadin antibodies.
The main issue with standard gluten intolerance blood
testing is that it only looks at
antibodies to one component of gluten called alpha
gliadin.
And also the
gliadin antibodies be the stool
testing we do.
My point is, unless a person has a stool
test for
gliadin antibodies, they do not know if they can safely eat wheat.
As mentioned earlier, standard
testing for gluten intolerance only
tests for
antibodies to one component of gluten, alpha
gliadin.
The limitations of currently available conventional
testing are very real as most physicians who do a «Celiac panel» are only
testing for alpha
gliadin, tissue transglutaminase 2, and endomesial
antibody.
Most
tests only check for
antibodies to alpha -
gliadin (one single gluten peptide), and not everyone with a gluten sensitivity reacts to that particular gluten peptide.
Your doctor's «celiac panel» is only
testing for alpha
gliadin, tissue transglutaminase 2, and endomesial
antibody, a small portion of the potential immune responses to this food.
The blood
test checks for elevated IgG
antibodies to native
gliadin.
The research shows that
antibody blood
tests with high specificity and sensitivity are tissue transglutaminase (tTG) and deamidated
gliadin peptides (DGP).
If you see a conventional medical doctor and have your blood
tested at a conventional medical laboratory for celiac disease / gluten sensitivity, you will be
tested for IgA and IgG
antibodies to the 33 - mer peptide of deamidated alpha -
gliadin and transglutaminase 2.
Some of these
tests include IgA anti
gliadin antibodies, IgA anti endomysial
antibodies, IgG anti
gliadin antibodies, total IgA
antibodies, intestinal biopsy etc..