Sentences with phrase «glial cell activation»

Avigen discovered the utility of AV411 through its internal program to develop innovative and targeted approaches to reducing nervous system dysfunction caused by glial cell activation.

Early blockade of injured primary sensory afferents reduces glial cell activation in two rat neuropathic pain models.

Not exact matches

Too much activation of p38 MAPK in glial cells impairs their supportive function and can result in the release of neurotoxic molecules further harming the synapse.

Although glial activation may have short - term benefits, there is consensus that in the long - term, these cells may contribute to the pathology of damaged neurons in glaucoma.

We show that subpopulations of human astrocytes, generated by activation of different signaling pathways in the same population of human glial precursor cells, have markedly different effects when transplanted into the injured spinal cord.

CFC investigators have also established a link between glial activation and oxidative damage in retinal ganglion cells.