Not exact matches
Some recent studies have suggested that
glial cells can secrete chemical messengers such as glutamate and ATP; if so, these «gliotransmitters» could influence neuron
activity.
Kozai's lab is currently working with Franca Cambi, professor of neurology at Pitt, on a project to understand the role of another type of
glial cell on brain injury and neuronal
activity.
«By combining in vivo multiphoton microscopy and in vivo electrophysiology, our lab is better able to visualize how
cells move and change over time in the living brain and explain how changes in these
glial cells alter the visually evoked neural network
activity,» says Kozai.
«From providing growth factor support and ensuring proper oxygen and nutrient delivery to the brain to trimming of obsolete synapses and recycling waste products, recent findings show that
glial cells do much more to ensure brain
activity is optimized,» Kozai says.
In addition, the researchers found that these
glial cells mediate the channel's
activity, assisting the flow of fluid through the channel.
LDN was also recently found to reverse allodynia in rats and is able to cross the blood - brain barrier and suppress the
activity of the immune
cells (
glial / microoglial) that promote inflammation in the brain.