«We were surprised that it was expressed in only a fraction of
glial cells after the injury.
Together, studies in zebrafish and mammalian models could inform new ways to manipulate
glial cells after human spinal cord injury.»
Not exact matches
These
cells are similar to brain astroglial
cells, and both types of
glial cells are activated
after TBI.
Researchers have identified a group of immune system genes that may play a role in how long people can live
after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the
glial cells in the brain.
Researchers were able to quantify the protective effect of dexamethasone treatment in protecting both satellite
glial cell and neuronal apoptosis; in contrast, meloxicam treatment was only effective in protecting against satellite
glial cell apoptosis and only
after prolonged administration.
Neuroscientists have long believed that scar tissue formed by
glial cells — the
cells that surround neurons in the central nervous system — impedes damaged nerve
cells from regrowing
after a brain or spinal cord injury.
«Within 3 weeks
after expression of the NeuroD1 protein, we saw in the microscope that human
glial cells were reinventing themselves: they changed their shape from flat sheet - like
glial cells into normal - looking neurons with axon and dendritic branches,» Chen said.
After 24 hours of culture the
glial cells and fibroblasts had survived and multiplied but the neurons had undergone a massive degeneration.
But
after five days of treating the injury with opiods, the
glial cells triggered a chain reaction, including spinal cord imflammation.
In the healthy brain, stem
cell - like
glial progenitors can divide, migrate to an injured site, and become mature oligodendrocytes
after myelin loss, but, unfortunately, the efficiency of remyelination declines with age.