Sentences with phrase «glial progenitor cells»
As a first step towards determining whether human glial progenitor cells (hGPCs) can generate functionally distinct astrocyte populations, we exposed embryonic hGPCs isolated from spinal cords of 9.5 week old abortuses to BMP or CNTF.
http://journals.plos.org/
The mammalian brain has a remarkable repair system due to abundant glial progenitor cells.
Transplantation of astrocytes generated by exposure of human glial progenitor cells (hGPCs) to BMP (hGDAsBMP) promoted robust behavioral recovery and multi-laminae protection of spinal cord neurons following spinal cord injury (SCI), while transplantation of undifferentiated hGPCs or astrocytes generated by hGPC exposure to CNTF (hGDAsCNTF) failed to provide such benefits.
The enhanced mice masterfully memorized new objects, swiftly learned to link certain sounds or situations to an unpleasant foot shock, and displayed un-usually savvy maze navigation — signs of mental acuity that surpassed skills exhibited by either typical mice or mice transplanted with glial progenitor cells from their own species.
Not exact matches
The mice benefited from human stem cells called glial progenitors, immature cells poised to become astrocytes and other glia cells, the supposed support cells of the brain.
They are produced during development from stem cells called glial progenitors.
Progenitors of the central retina are the first to leave the cell cycle and differentiate into the six neuronal and one glial cell class of the mature retina.
Human stem / progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling.
In the healthy brain, stem cell - like glial progenitors can divide, migrate to an injured site, and become mature oligodendrocytes after myelin loss, but, unfortunately, the efficiency of remyelination declines with age.
The authors transplanted human cortical ‐ derived neural progenitor cells engineered to secrete glial cell line ‐ derived neurotrophic factor (GDNF) into the cortex of a rat model of ALS, where the cells migrated, matured into astrocytes, and released GDNF.
Immunocytochemical staining for Ki67 (cell proliferation marker), Sox2 (neural stem cell marker), Olig2 (progenitor cell marker), and GFAP (glial fibrillary acidic protein, a marker for differentiated astrocytes) captured by confocal microscopy imaging.