So several years ago, Chen's lab tested new ways to transform
glial scar tissue back to normal neural tissue.
«Spinal cord regeneration might actually be helped by
glial scar tissue: Research finds that nerve cells regrow better when glial scarring is left intact.»
Not exact matches
In addition to inflammation, previous microelectrode brain implants made of silicon or microwire have caused neuronal death and
glial scarring, which is damage to connective
tissue in the nervous system.
«The most obvious function of
glial cells has been related to their role in forming
scar tissue to prevent the spread of injury and neuronal degeneration, but so much about their role in the brain is unknown.»
Doctors have long figured that the major roadblock to recovery was the
scar tissue formed by a type of
glial cells called astrocytes.
Neuroscientists have long believed that
scar tissue formed by
glial cells — the cells that surround neurons in the central nervous system — impedes damaged nerve cells from regrowing after a brain or spinal cord injury.
Dr. Ding will soon begin to use regenerative medicine to transform these inhibitory
glial cells into a non-inhibitory CNS cell type, eliminating the field of
scar tissue and permitting the transmission of axonal signals.
By contrast, when a human suffers a spinal cord injury, the
glial cells form
scar tissue, which blocks nerves from ever reconnecting with each other.
For more than a century, scientists thought that
glial cells were responsible for
scar formation; now, however, a paper published in Science shows that spinal cord
scar tissue largely derives from a completely unexpected type of cell called a pericyte, opening new opportunities for the treatment of damaged nerve
tissue.Lesions to the brain or spinal cord rarely heal fully, which leads to permanent functional impairment.
The key goal of therapy during the acute stage is to reduce the
scar tissue within the damaged spinal cord «
glial scar» that may impede future healing.