Sentences with phrase «gliobastoma multiforme»

Glioblastoma multiforme is the most common and deadliest of the glial tumors because the cells reproduce so rapidly.

A CAT scan and an MRI lead to a diagnosis more daunting than the first: glioblastoma multiforme, grade 4.

The tumor is called a Glioblastoma multiforme: also called The Terminator.

The former Labour cabinet minister who was diagnosed with a glioblastoma multiforme brain tumour in May last year, suffered a haemorrhage on Friday, and had been in a coma until her death on Saturday, a spokesman for the family said.

The ground - breaking technique could eventually be used to treat glioblastoma multiforme, which is the most common and aggressive brain tumour in adults, and notoriously difficult to treat.

To date, glioblastoma multiforme (GBM) has proven very resistant to treatments.

The investigators report that trapping virus - loaded stem cells in a gel and applying them to tumors significantly improved survival in mice with glioblastoma multiforme, the most common brain tumor in human adults and also the most difficult to treat.

The research identifies a potential characteristic for predicting outcome in a deadly form of brain cancer known as glioblastoma multiforme.

Glioblastoma multiforme is the most common and aggressive form of brain cancer, with a median survival of about 15 months.

In 2002 scientists showed that cytomegalovirus, or CMV, was active in the brain tumors but not the surrounding healthy tissue of all 27 patients they tested who had glioblastoma multiforme.

For patients with glioblastoma multiforme, the vaccine did not seem to prevent the recurrence of cancer, so those patients were offered follow - up chemotherapy.

In a study published in the Journal of NeuroOncology, TGen researchers report that PPF works to limit the spread of glioblastoma multiforme, or GBM — the most common primary tumor of the brain and central nervous system — by targeting a protein called TROY.

Researchers have identified a group of immune system genes that may play a role in how long people can live after developing a common type of brain cancer called glioblastoma multiforme, a tumor of the glial cells in the brain.

The data suggests that the upregulation of MMP2 resulting from decreased Id4 expression in glioblastoma multiforme (GBM) may contribute to the morbidity and mortality of GBM patients.

Trial # 1: A phase I / II trial of HCQ in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

Most people with glioblastoma multiforme die within a year of diagnosis, as standard treatments can not eradicate these tumours.

The loss of the tumor suppressor gene PTEN has been linked to tumor growth and chemotherapy resistance in the almost invariably lethal brain cancer glioblastoma multiforme (GBM).

The results suggest the simultaneous activation of certain molecular pathways — actions among molecules in a cell that can lead to change — in particular the MAPK and PI3K cellular pathways, triggered tumor initiation and produced increasingly dense low - grade gliomas that quickly progressed to glioblastoma multiforme (GBM).

This compares with 14 months for patients with glioblastoma multiforme — a complex and aggressive astrocytoma.

«In principle, both these features make GA11 an attractive drug candidate to target glioma stem - like cells in glioblastoma multiforme tumors,» said Ichiro Nakano, M.D., Ph.D., and colleagues in the paper.

The tumors studied fell into the broad category of high - grade gliomas: diffuse intrinsic pontine glioma, which strikes school - aged children; pediatric cortical glioblastoma, which affects primarily teens and young adults; anaplastic oligodendroglioma, which affects young adults; and glioblastoma multiforme, which affects older adults.

The median survival rate for patients with glioblastoma multiforme, or GBM, is a mere 14.2 months.

The researchers are currently enrolling patients with stage 4 lung cancer and will soon begin enrolling people with glioblastoma multiforme (brain cancer) in these phase II trials.

The cost per patient above standard insurance billing for the phase II vitamin C glioblastoma multiforme protocol is approximately $ 8000 spread over 9 months of test infusions.

This guarded optimism is based on the phase I trial data showing an increase in overall survival of 4 - 6 months in 11 glioblastoma multiforme patients (18 - 22 months) versus the 14 - 16 months survival typically seen with the standard treatment.

Patients with recurrent glioblastoma multiforme (GBM) treated with an experimental vaccine made from the patient's own resected tumor tissue showed an improved survival compared with historical patients who received the standard of care alone, according to an analysis of a phase 2 trial of this vaccine that was recently published in the journal Neuro - Oncology and accompanied by an editorial highlighting the importance of the trial.

«Glioblastma multiforme: Researchers find promise in new treatments.»

To date, the TCGA Research Network has generated data and published analyses on glioblastoma multiforme, ovarian serous adenocarcinoma, colorectal adenocarcinoma, lung squamous cell carcinoma and invasive breast cancer.

Abrogation of PIK3CA or PIK3R1 reduces proliferation, migration, and invasion in glioblastoma multiforme cells.

In addition to developing the new genetically engineered mouse model for the form of cancer called glioblastoma multiforme, the researchers made a key discovery about brain tumor biology via the mice.

My laboratory studies the biology of glioblastoma multiforme (GBM), the most aggressive subtype of brain tumors.

Our intellectual property and the extensive experience of our team in discovering and developing novel diagnostic tests will enable us to provide the most accurate glioblastoma multiforme subtyping test available.»

There is another report by Bai et al which showed the role of TRF2 in maintenance of neurospheres in glioblastoma multiforme (GBM)[18].

However, they did not detect the presence of viruses in breast cancer or glioblastoma multiforme (cancer of the brain), both of which have been suggested to have a viral cause.

Dr Steve Pollard and his team are developing potential new treatments for the most common type of brain tumour in adults, known as glioblastoma multiforme.

Differential effects of low - and high - dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion.

Glioblastoma multiforme (GBM), an aggressive brain tumor affecting both adults and children, has dismal outcomes as well:

Berkeley Lab researchers have developed a new family of nanocarriers, called «3HM,» that meets all the size and stability requirements for effectively delivering therapeutic drugs to the brain for the treatment of a deadly form of cancer known as glioblastoma multiforme.

LA JOLLA — Glioblastoma multiforme is a particularly deadly cancer.

LA JOLLA, CA — Scientists have long believed that glioblastoma multiforme (GBM), the most aggressive type of primary brain tumor, begins in glial cells that make up supportive tissue in the brain...

ISB's brain - related research spans across nine of our lab groups and covers such diseases as Alzheimer's, ALS, glioblastoma multiforme, bipolar disorder, and PTSD.

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

«High grade glioma» can include: Glioblastoma multiforme (WHO grade IV); Anaplastic astrocytoma (WHO grade III); Anaplastic oligodendroglioma (WHO grade III); and Anaplastic ependymoma (WHO grade III).

As part of the Cancer Genome Atlas (TCGA) consortium, we're working on glioblastoma multiforme (brain cancer) and ovarian cancer.

In this latest study, the TCGA researchers built upon the approach they used in 2008 to characterize the genome of gliobastoma multiforme, the most common form of brain cancer.

A phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Whereas, a phase I / II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme led to no significant improvement in overall survival, which could be due to inconsistent autophagy inhibition in patients treated with this regimen [29].

Glioblastoma multiforme (GBM) is considered the most malignant of primary brain cancers with only about 12 % of patients living beyond 36 months (long - term survivors).

A 65 - year old woman who was suffering from glioblastoma multiforme (GBM), an aggressive type of brain cancer, was put into a restricted ketogenic diet that started with water fasting and then proceeded to consume 600 calories a day only.

These preclinical studies have led to a clinical trial for patients with glioblastoma multiforme (www.clinicaltrials.gov NCT02046187).