Sentences with phrase «glioblastoma cells by»

In addition to diminishing the tumor's energy supply, the diet slows the growth of glioblastoma cells by altering a cellular - signaling pathway that commonly occurs in cancers, according to the researchers.

Not exact matches

Using human - derived glioblastoma cells in a mouse models, researchers found that the modified high - fat, low - carbohydrate diet increased life expectancy by 50 percent while also reducing tumor progression by a similar amount.

By combining this strategy with cancer cell - targeting materials, we should be able to develop a therapy for glioblastoma and other challenging cancers in the future.»

A study led by researchers at The Ohio State University Comprehensive Cancer Center — Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC — James) has identified an abnormal metabolic pathway that drives cancer - cell growth in a particular glioblastoma subtype.

A neuro - oncology research team at Dartmouth's Norris Cotton Cancer Center, led by the Director Mark A. Israel, MD with first author Gilbert J. Rahme, PhD, recently identified the transcription factor Id4 as a suppressor of tumor cell invasion in glioblastoma.

Their paper, «Id4 suppresses MMP2 - mediated invasion of glioblastoma - derived cells by direct inactivation of Twist1 function,» was recently published in Oncogene.

Glioblastoma is the most lethal form of primary brain tumor and leads to death in patients by invading the brain tissue in a process that allows single cells to move through normal brain tissue, which makes complete surgical removal of the tumor impossible.

Shah next plans to rationally combine the toxin - secreting stem cells with a number of different therapeutic stem cells developed by his team to further enhance their positive results in mouse models of glioblastoma, the most common brain tumor in human adults.

To identify the main compounds (metabolites) produced by glioblastoma cells during infection by Zika, the researchers analyzed the cells using matrix - assisted laser desorption / ionization mass spectrometry imaging (MALDI - MSI).

Because digoxin and other cardiac glycosides have been shown to induce cancer cell death, the researchers concluded that infection by Zika triggered synthesis of the molecule in glioblastoma cells and that this phenomenon is probably one of the factors that lead to neuronal cell death.

Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated celGlioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated celglioblastoma cells that were associated with a more differentiated cell of origin.

A new study published in the Oct. 9 issue of the journal Nature Medicine demonstrates, for the first time, that glioblastoma (GBM), the most common and most lethal brain tumor, is driven by two distinct subsets of cancer stem cells.

«By treating glioblastoma cells with decitabine, we found that we can unmask targets on the tumor cell that can be recognized by killer T cellBy treating glioblastoma cells with decitabine, we found that we can unmask targets on the tumor cell that can be recognized by killer T cellby killer T cells.

A research team led by Christine Brown, Ph.D., and a clinical team headed by Behnam Badie, M.D., has received a $ 12.8 million grant from the CIRM to fund a phase 1 chimeric antigen receptor (CAR) T cell trial targeting an aggressive brain cancer called malignant glioma, which includes glioblastoma.

Inhibition of the self - renewal in CD133 - positive glioblastoma TICs by PPAM was attributed to inhibition of stem cell regulatory pathways [67].

Analysis of glioblastoma tumor coverage by oncolytic virus - loaded neural stem cells using MRI - based tracking and histological reconstruction.

Identification of novel small - molecule inhibitors of glioblastoma cell growth and invasion by high - throughput screening.

The TRPC channel blocker SKF 96365 Inhibits Glioblastoma Cell Growth by Enhancing Reverse Mode of the Na + / Ca2 + Exchanger and Increasing Intracellular Ca2 +.

Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by β8 integrin.

Regulation of Glioblastoma Tumor - Propagating Cells by the Integrin Partner Tetraspanin CD151.

The company's lead candidate, GLN - 1001, is a first - in - class, orally available oncolytic small molecule, currently being developed as a potentially disease modifying therapy for glioblastoma by targeting specific vulnerabilities in tumor cells.

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell, 17 (1), 98 - 110 DOI: 10.1016 / j.ccr.2009.12.020

BAI1 is produced by brain cells naturally, but is often silenced epigenetically in glioblastoma cells.