Glioblastoma cells from patients that could be linked by the gene signature analysis with an immature origin generally showed a higher sensitivity to cancer drugs than glioblastoma cells that were associated with a more differentiated cell of origin.
According to his unpublished findings, when he puts
glioblastoma cells from patients into lab dishes with brain organoids, the cells attach to the surface of the organoids, burrow into them, and within 24 to 48 hours grow into a mass that eventually «looks exactly like what happened in the patient's own brain,» Fine said.
Not exact matches
They are also getting skin
cells from glioblastoma patients to make sure the new method works for the people they hope to help, he says.
These were released into tumour
cells that had been taken
from glioblastoma patients and grown in the lab.
From tissue and cell samples from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the
From tissue and
cell samples
from five glioblastoma patients, the scientists obtained 33 individual cancer cells capable of reproduction, which grew into very different tumors in the
from five
glioblastoma patients, the scientists obtained 33 individual cancer
cells capable of reproduction, which grew into very different tumors in the lab.
But for the last month or so, they have been making them
from brain
cells of
glioblastoma patients.
In collaboration with co-senior authors Diamond and Milan G. Chheda, MD, of Washington University School of Medicine, and Jeremy N. Rich, MD, of UC San Diego, Zhu tested whether the virus could kill stem
cells in
glioblastomas removed
from patients at diagnosis.
«When we compared the gene signature activity of
glioblastoma cells from around 60
patients we found that a large number of
patients could be divided into subgroups that showed a correlation between gene activity, tumor
cell characteristics and
cell of origin similar to the one we had seen in the mouse study.
The study compared multiple techniques — or assays — used to analyze genomic data
from a
glioblastoma patient's tumor
cells and normal healthy
cells.